2025-01-01
The characterization of tumor immune microenvironment after neoadjuvant immunotherapy in head and neck squamous cell cancer using multiplex immunohistochemistry
2025-01-01 • Zhaohong An, Xiwei Zhang, Zhaoyang Wang, Dilinaer Wusiman, Xiaohui Zhao, Lian Li, Lei Guo, Minghui Wei, Wenbin Li, Changming An
The presence of T cells demonstrated significant predictive capability for responses to neoadjuvant immunotherapy in HNSCC patients. Furthermore, TIM3<sup>+</sup> T cells and LAG3<sup>+</sup> T cells were found to be remarkably lower in the partial response (PR) cohort than in the non-partial response (NPR) cohort post-treatment. This research contributes critical understanding of the physiological changes occurring in immune cell responses.