Changming Xiong
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View article: Pulmonary arterial compliance as a long-term prognostic indicator in pulmonary arterial hypertension associated with adult congenital heart disease: results from a National multicenter prospective registry
Pulmonary arterial compliance as a long-term prognostic indicator in pulmonary arterial hypertension associated with adult congenital heart disease: results from a National multicenter prospective registry Open
ClinicalTrials.gov (NCT01417338), registered 16th August 2011.
View article: Multiple Imaging Modalities in the Diagnosis of Infective Endocarditis
Multiple Imaging Modalities in the Diagnosis of Infective Endocarditis Open
Infective endocarditis (IE) is an inflammatory disease caused by the infection of the endocardium or heart valves by pathogenic microorganisms. It is characterized by diagnostic challenges, difficult treatment, and high mortality. Multimod…
View article: Pulmonary arterial compliance as a long-term prognostic indicator in pulmonary arterial hypertension associated with adult congenital heart disease: results from a national multicenter prospective registry
Pulmonary arterial compliance as a long-term prognostic indicator in pulmonary arterial hypertension associated with adult congenital heart disease: results from a national multicenter prospective registry Open
Background Pulmonary arterial compliance (PAC) reflects the pulsatile load and predicts outcome in pulmonary arterial hypertension (PAH). The prognostic role of PAC in the heterogeneous patient population of PAH associated with congenital …
View article: Trends and projections of heart failure among adolescents and young adults: an in-depth analysis for the Global Burden of Disease Study 2021
Trends and projections of heart failure among adolescents and young adults: an in-depth analysis for the Global Burden of Disease Study 2021 Open
Aims The prevalence of heart failure (HF) continues to rise with a growing impact on younger populations, while epidemiological comprehensive data on HF in adolescents and young adults remain scarce. This study aimed to report population s…
View article: Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease
Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease Open
View article: Gut Microbial Metabolism of Cinnabarinic Acid Promotes to the Role of Pseudolaric Acid B Against Metabolic Dysfunction-Associated Fatty Liver Disease
Gut Microbial Metabolism of Cinnabarinic Acid Promotes to the Role of Pseudolaric Acid B Against Metabolic Dysfunction-Associated Fatty Liver Disease Open
View article: The Challenge in Burden of Pulmonary Arterial Hypertension: A Perspective From the Global Burden of Disease Study
The Challenge in Burden of Pulmonary Arterial Hypertension: A Perspective From the Global Burden of Disease Study Open
Pulmonary arterial hypertension (PAH) poses significant clinical management challenges due to gaps in understanding its global epidemiology. We analyzed PAH‐related disability‐adjusted life years (DALYs), deaths, and prevalence from 1990 t…
View article: Epidemiology and management patterns of chronic thromboembolic pulmonary hypertension in China
Epidemiology and management patterns of chronic thromboembolic pulmonary hypertension in China Open
View article: Global research trends on chronic thromboembolic pulmonary hypertension: a bibliometric analysis (January 2000–January 2024)
Global research trends on chronic thromboembolic pulmonary hypertension: a bibliometric analysis (January 2000–January 2024) Open
The number of publications on CTEPH has increased over the last two decades, and CTEPH has become a significant topic in both respirology and cardiology. Our results indicate that future research in this field will continue to focus on elu…
View article: Gut Microbiota-Based Metabolism of Cinnabarinic Acid Contributes to the Protective Effect of Pseudolaric Acid B Against Metabolic Dysfunction-Associated Fatty Liver Disease
Gut Microbiota-Based Metabolism of Cinnabarinic Acid Contributes to the Protective Effect of Pseudolaric Acid B Against Metabolic Dysfunction-Associated Fatty Liver Disease Open
View article: The management pattern and outcomes of chronic thromboembolic pulmonary hypertension: rationale and design for a Chinese real-world study
The management pattern and outcomes of chronic thromboembolic pulmonary hypertension: rationale and design for a Chinese real-world study Open
Background Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive pulmonary vascular disorder with substantial morbidity and mortality, also a disease underdiagnosed and undertreated. It is potentially curable by pulmonary …
View article: Platypnea-Orthodeoxia Syndrome Due to Atrial Septal Defect with Congenital Variation in the Position of the Atrial Septum and Combined Thoracic Deformities in a Young Man
Platypnea-Orthodeoxia Syndrome Due to Atrial Septal Defect with Congenital Variation in the Position of the Atrial Septum and Combined Thoracic Deformities in a Young Man Open
Platypnea-orthodeoxia syndrome (POS) is a rare and complicated clinical entity with low recognition rate. The mechanisms of POS are broadly divided into intracardiac and intrapulmonary, while the detailed pathogenesis is less understood. H…
View article: Geometric remodeling of tricuspid valve in pulmonary hypertension and its correlation with pulmonary hypertension severity: a prospectively case-control study using four-dimensional automatic tricuspid valve quantification technology
Geometric remodeling of tricuspid valve in pulmonary hypertension and its correlation with pulmonary hypertension severity: a prospectively case-control study using four-dimensional automatic tricuspid valve quantification technology Open
In PH, TV geometric remodeling occurs mainly in TA septal-lateral dimension and TV tenting height. Worsening PH is an independent determinant of TV coaptation point height and MTH, not TA size. MTH shows a great diagnostic potential to det…
View article: Circulating acetylcholine serves as a potential biomarker role in pulmonary hypertension
Circulating acetylcholine serves as a potential biomarker role in pulmonary hypertension Open
View article: Preliminary Evaluation of the Protective Effect of R Ei -Sag19 on Eimeria Intestinalis Infection in Rabbits
Preliminary Evaluation of the Protective Effect of R Ei -Sag19 on Eimeria Intestinalis Infection in Rabbits Open
View article: Optimal short-term outcomes in balloon pulmonary angioplasty: the minimum frequency of three sessions annually
Optimal short-term outcomes in balloon pulmonary angioplasty: the minimum frequency of three sessions annually Open
Background: Balloon pulmonary angioplasty (BPA) is typically performed in a sequential manner. Objectives: This study aimed to determine the lowest frequency of BPA for patients who could not reach treatment goals in a short period. Design…
View article: Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota
Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota Open
The gut microbiota is a complex community of microorganisms inhabiting the intestinal tract, which plays a vital role in human health. It is intricately involved in the metabolism, and it also affects diverse physiological processes. The g…
View article: The significance of dynamic monitoring plasma TMAO level in pulmonary arterial hypertension – a cohort study
The significance of dynamic monitoring plasma TMAO level in pulmonary arterial hypertension – a cohort study Open
Background: Gut microbiota assumes an essential role in the development and progression of pulmonary arterial hypertension (PAH). Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite, is correlated with the prognosis of pat…
View article: Angiographic classification of total occlusion and its implication on balloon pulmonary angioplasty
Angiographic classification of total occlusion and its implication on balloon pulmonary angioplasty Open
Aims Despite refinements in balloon pulmonary angioplasty (BPA), total occlusion remains a challenge in chronic thromboembolic pulmonary hypertension (CTEPH). Owing to their low success and high complication rates, most interventional card…
View article: Etiological classification and manifestation of pulmonary artery dissection: A literature review and case analysis
Etiological classification and manifestation of pulmonary artery dissection: A literature review and case analysis Open
PAD aetiology can be divided into four main categories, with CHD associated with PAH being the leading cause. Despite the similar histopathology features, clinical manifestations and outcomes vary according to the aetiology.
View article: Clinical features and long-term survival in idiopathic pulmonary arterial hypertension with thyroid dysfunction: insights from a national multicentre prospective study
Clinical features and long-term survival in idiopathic pulmonary arterial hypertension with thyroid dysfunction: insights from a national multicentre prospective study Open
Background Our objective was to clarify the characteristics and long-term survival of idiopathic pulmonary arterial hypertension (IPAH) patients with thyroid dysfunction and compare them with IPAH without thyroid dysfunction. Methods A ret…
View article: Protection against <i>Eimeria intestinalis</i> infection in rabbits immunized with the recombinant elongation factors EF1α and EFG
Protection against <i>Eimeria intestinalis</i> infection in rabbits immunized with the recombinant elongation factors EF1α and EFG Open
Eimeria intestinalis is the most pathogenic species of rabbit coccidiosis, causing weight loss, diarrhea, and even acute death. The currently used anticoccidial drugs against E. intestinalis in rabbits are associated with drug resistance a…
View article: Pulmonary artery dilatation in different causes of pulmonary hypertension
Pulmonary artery dilatation in different causes of pulmonary hypertension Open
Pulmonary artery (PA) dilatation is commonly observed in patients with pulmonary hypertension (PH). However, the clinical aspects of PA dilatation in various etiology of PH remain unknown. In this study, we investigated the clinical and im…
View article: Assessment of the Immunoprotective Efficacy of Recombinant 14-3-3 Protein and Dense Granule Protein 10 (GRA10) as Candidate Antigens for Rabbit Vaccines against Eimeria intestinalis
Assessment of the Immunoprotective Efficacy of Recombinant 14-3-3 Protein and Dense Granule Protein 10 (GRA10) as Candidate Antigens for Rabbit Vaccines against Eimeria intestinalis Open
Eimeria intestinalis infects rabbits, causing severe intestinal coccidiosis. Prolonged anticoccidial drug use might lead to coccidia resistance and drug residues in food. Thus, vaccines are required to control rabbit coccidiosis. In this s…
View article: Right heart thrombus in acute pulmonary embolism: A single center experience in China
Right heart thrombus in acute pulmonary embolism: A single center experience in China Open
Right heart thrombus (RHT) is a rare but life‐threatening condition in acute pulmonary embolism (APE) without clear management guidelines. This study aimed to address the clinical characteristics and outcomes of RHT‐APE in Chinese patients…
View article: Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases
Pleiotropic activities of succinate: The interplay between gut microbiota and cardiovascular diseases Open
Cardiovascular diseases (CVDs) continue to be a significant contributor to global mortality, imposing a substantial burden and emphasizing the urgent need for disease control to save lives and prevent disability. With advancements in techn…
View article: 10-year survival of pulmonary arterial hypertension associated with connective tissue disease: insights from a multicentre PAH registry
10-year survival of pulmonary arterial hypertension associated with connective tissue disease: insights from a multicentre PAH registry Open
Objectives To report the 10-year survival rate and prognostic factors of pulmonary arterial hypertension associated with CTD (CTD-PAH) patients, to compare treatment and survival between patients enrolled before and after 2015, and to vali…
View article: Alerting trends in epidemiology for calcific aortic valve disease, 1990–2019: An age–period–cohort analysis for the Global Burden of Disease Study 2019
Alerting trends in epidemiology for calcific aortic valve disease, 1990–2019: An age–period–cohort analysis for the Global Burden of Disease Study 2019 Open
Aims To assess the trends in calcific aortic valve disease (CAVD) epidemiology, with an emphasis on CAVD mortality, leading risk factors, and their associations with age, period, and birth cohort. Methods and results Prevalence, disability…
View article: Development and Validation of a Nomogram for Balloon Pulmonary Angioplasty-Related Complications in Patients with Chronic Thromboembolic Pulmonary Hypertension
Development and Validation of a Nomogram for Balloon Pulmonary Angioplasty-Related Complications in Patients with Chronic Thromboembolic Pulmonary Hypertension Open
Background: Balloon pulmonary angioplasty (BPA)-related complications are not uncommon and could contribute to perioperative mortality. However, there is a lack of a prediction model for BPA-related complications. Methods: Data from consec…
View article: Mass Cytometry Reveals the Imbalanced Immune State in the Peripheral Blood of Patients with Essential Hypertension
Mass Cytometry Reveals the Imbalanced Immune State in the Peripheral Blood of Patients with Essential Hypertension Open
Mounting evidence has confirmed that essential hypertension (EH) is closely related to low-grade inflammation, but there is still a lack of in-depth understanding of the state of immune cells in the circulating blood of patients with EH. W…