Changsheng Liu
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View article: Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling Open
Eleutheroside E (EE), a natural compound, shows promise in mitigating cellular senescence—a key factor in skin aging—though its mechanisms remain incompletely understood. This study integrated network pharmacology, molecular docking, and c…
View article: Effect of age on substantia nigra subregions using neuromelanin-sensitive magnetic resonance imaging overlapping on quantitative susceptibility mapping
Effect of age on substantia nigra subregions using neuromelanin-sensitive magnetic resonance imaging overlapping on quantitative susceptibility mapping Open
Effect of age on NM-MRI measures varied across the SN subregions. The relationship between CRs and MTR in the dorsal and ventral SN as well as between CRs and QSM value in dorsal SN could be referential for pathological conditions.
View article: Selenium-Containing Nano-Micelles Delay the Cellular Senescence of BMSCs Under Oxidative Environment and Maintain Their Regenerative Capacity
Selenium-Containing Nano-Micelles Delay the Cellular Senescence of BMSCs Under Oxidative Environment and Maintain Their Regenerative Capacity Open
The cellular senescence and functional decline of stem cells are primary contributors to the reduced regenerative capacity and weakened disease resistance in aged tissues. Among the various factors involved, oxidative stress resulting from…
View article: Mannose Oligosaccharide‐Conjugated In Situ Pore‐Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles
Mannose Oligosaccharide‐Conjugated In Situ Pore‐Forming Injectable Hydrogels for Rheumatoid Arthritis Treatment by Reprogramming Macrophage Extracellular Vesicles Open
Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes severe cartilage erosion in joints. Current treatments are limited in accessing a 3D platform that not only supports chondrocyte recovery and new cartilage matrix form…
View article: Engineering a functionality-integrated artificial cornea stromal Substitute: Janus bio-adhesive implant with a collagen-based multi-scale biomimetic skeleton
Engineering a functionality-integrated artificial cornea stromal Substitute: Janus bio-adhesive implant with a collagen-based multi-scale biomimetic skeleton Open
View article: Biomaterials and materiobiology as the continuous powerhouse of biomedical innovation for our aging society
Biomaterials and materiobiology as the continuous powerhouse of biomedical innovation for our aging society Open
View article: An "inside-out"-guided genetically engineered hydrogel for augmenting aged bone regeneration
An "inside-out"-guided genetically engineered hydrogel for augmenting aged bone regeneration Open
View article: Breaking the Cost Barrier: How Environmental Policy Intensity and Cost Stickiness Shape Green Innovation in China’s Manufacturing Sector
Breaking the Cost Barrier: How Environmental Policy Intensity and Cost Stickiness Shape Green Innovation in China’s Manufacturing Sector Open
Facing a society that has accumulated many ecological and environmental problems, green technology innovation has gradually become an effective way to test the efficiency of environmental policies. This study investigated the impact of env…
View article: Identification and mechanism analysis of biomarkers related to butyrate metabolism in COVID-19 patients
Identification and mechanism analysis of biomarkers related to butyrate metabolism in COVID-19 patients Open
These five genes may be potential biomarkers of butyrate metabolism in COVID-19 patients. These findings provide a direction for further studies on the molecular mechanisms underlying COVID-19.
View article: The m6A Methylation Profile Identified That OsHMT9.1 Deregulates Chromium Toxicity in Rice (Oryza sativa L.) Through Negative Regulatory Functions
The m6A Methylation Profile Identified That OsHMT9.1 Deregulates Chromium Toxicity in Rice (Oryza sativa L.) Through Negative Regulatory Functions Open
Chromium (Cr) is a toxic heavy metal that affects the food chain and poses a severe threat to food safety. Nonetheless, the N6-methyladenosine (m6A) transcriptomic regulation mechanisms of Cr tolerance genes in rice are not well understood…
View article: Pressure-Driven Flavor Formation in Rapeseed Oil: An Integrated Multi-Omics Approach
Pressure-Driven Flavor Formation in Rapeseed Oil: An Integrated Multi-Omics Approach Open
View article: Improvement of Microstructure and Properties of Nb-16si-22ti-3al Alloys Fabricated by Laser Melting Deposition with Tab2 Addition
Improvement of Microstructure and Properties of Nb-16si-22ti-3al Alloys Fabricated by Laser Melting Deposition with Tab2 Addition Open
View article: Targeted delivery of liposomal senolytics to alleviate cellular senescence-induced bone loss
Targeted delivery of liposomal senolytics to alleviate cellular senescence-induced bone loss Open
The senescence of bone marrow-derived mesenchymal stem cells is involved in osteoporosis. The combination of dasatinib and quercetin has been explored to alleviate bone loss by efficiently reducing senescent cell populations. However, seno…
View article: Tunable piezoelectric PLLA nanofiber membranes for enhanced mandibular repair with optimal self-powering stimulation
Tunable piezoelectric PLLA nanofiber membranes for enhanced mandibular repair with optimal self-powering stimulation Open
Poly (l-lactic acid) (PLLA) is a biocompatible, biodegradable material with piezoelectric properties, making it a promising candidate for providing self-powered stimulation to accelerate tissue repair. Repairs to various tissues, such as b…
View article: Biomimetic 3D printing of photocrosslinkable biodegradable elastomers-modified hybrid scaffolds as instructive platforms for bone tissue regeneration
Biomimetic 3D printing of photocrosslinkable biodegradable elastomers-modified hybrid scaffolds as instructive platforms for bone tissue regeneration Open
3D printing is regarded as an ideal method for large-scale bone defect repair. A rapid curing rate and strong mechanical properties throughout the product's shelf life are key development goals in 3D-printed bone repair biomaterials. To ac…
View article: Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction
Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction Open
Polyethylene terephthalate (PET) artificial ligaments are widely used in anterior cruciate ligament (ACL) reconstruction due to their high tensile strength. However, bone tunnel enlargement around PET ligaments poses a risk for surgical fa…
View article: Injectable double-crosslinked bone cement with enhanced bone adhesion and improved osteoporotic pathophysiological microenvironment for osteoregeneration in osteoporosis
Injectable double-crosslinked bone cement with enhanced bone adhesion and improved osteoporotic pathophysiological microenvironment for osteoregeneration in osteoporosis Open
The osteoporotic bone defect caused by excessive activity of osteoclasts has posed a challenge for public healthcare. However, most existing bioinert bone cement fails to effectively regulate the pathological bone microenvironment and reco…
View article: Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment (Adv. Sci. 13/2024)
Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment (Adv. Sci. 13/2024) Open
Advanced Janus Film for Periodontitis Treatment In article number 2305756, Xuehui Zhang, Xue Qu, and co‐workers report a salt effect modulated electro‐assembly technique for collagen film to customize its porous microstructures and functio…
View article: Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration
Electro‐Sorting Create Heterogeneity: Constructing A Multifunctional Janus Film with Integrated Compositional and Microstructural Gradients for Guided Bone Regeneration Open
Biology remains the envy of flexible soft matter fabrication because it can satisfy multiple functional needs by organizing a small set of proteins and polysaccharides into hierarchical systems with controlled heterogeneity in composition …
View article: Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment
Programmable Electro‐Assembly of Collagen: Constructing Porous Janus Films with Customized Dual Signals for Immunomodulation and Tissue Regeneration in Periodontitis Treatment Open
Currently available guided bone regeneration (GBR) films lack active immunomodulation and sufficient osteogenic ability‐ in the treatment of periodontitis, leading to unsatisfactory treatment outcomes. Challenges remain in developing simpl…
View article: Self-Restoring Cryogels Used for the Repair of Hemorrhagic Bone Defects by Modulating Blood Clots
Self-Restoring Cryogels Used for the Repair of Hemorrhagic Bone Defects by Modulating Blood Clots Open
View article: Advancing homogeneous networking principles for the development of fatigue-resistant, low-swelling and sprayable hydrogels for sealing wet, dynamic and concealed wounds in vivo
Advancing homogeneous networking principles for the development of fatigue-resistant, low-swelling and sprayable hydrogels for sealing wet, dynamic and concealed wounds in vivo Open
Effective sealing of wet, dynamic and concealed wounds remains a formidable challenge in clinical practice. Sprayable hydrogel sealants are promising due to their ability to cover a wide area rapidly, but they face limitations in dynamic a…
View article: Study on the application of two magnesium salts in low temperature adsorption refining of fragrant rapeseed oil
Study on the application of two magnesium salts in low temperature adsorption refining of fragrant rapeseed oil Open
Magnesium silicate and basic magnesium carbonate were characterized and their application in the low temperature adsorption refining of fragrant rapeseed oil was investigated. The results showed that both materials had a loose porous struc…
View article: Usefulness of T2-Weighted Images with Deep-Learning-Based Reconstruction in Nasal Cartilage
Usefulness of T2-Weighted Images with Deep-Learning-Based Reconstruction in Nasal Cartilage Open
Objective: This study aims to evaluate the feasibility of visualizing nasal cartilage using deep-learning-based reconstruction (DLR) fast spin-echo (FSE) imaging in comparison to three-dimensional fast spoiled gradient-echo (3D FSPGR) imag…
View article: Engineered biomaterials in stem cell-based regenerative medicine
Engineered biomaterials in stem cell-based regenerative medicine Open
Stem cell-based regenerative therapies, which harness the self-renewal and differentiation properties of stem cells, have been in the spotlight due to their widespread applications in treating degenerative, aging, and other, generally intr…
View article: A suture-free, shape self-adaptive and bioactive PEG-Lysozyme implant for Corneal stroma defect repair and rapid vision restoration
A suture-free, shape self-adaptive and bioactive PEG-Lysozyme implant for Corneal stroma defect repair and rapid vision restoration Open
Corneal transplantation is a prevailing treatment to repair injured cornea and restore vision but faces the limitation of donor tissue shortage clinically. In addition, suturing-needed transplantation potentially causes postoperative compl…
View article: Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns
Harnessing strategies for enhancing diabetic wound healing from the perspective of spatial inflammation patterns Open
Diabetic wound is a great threat to patient's health and lives. The refractory diabetic wound shows spatial inflammation patterns, in which the early-wound pattern depicts a deprived acute inflammatory response, and the long-term non-heali…
View article: High Content of Thermoplastic Starch, Poly(butylenes adipate-co-terephthalate) and Poly(butylene succinate) Ternary Blends with a Good Balance in Strength and Toughness
High Content of Thermoplastic Starch, Poly(butylenes adipate-co-terephthalate) and Poly(butylene succinate) Ternary Blends with a Good Balance in Strength and Toughness Open
The ternary blends of a high content of thermoplastic starch (TPS), poly(butylenes adipate-co-terephthalate) (PBAT), and poly(butylene succinate) (PBS) were first melt-compounded in a twin screw extruder. The TPS contents in ternary blends…
View article: Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy
Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy Open
View article: Injectable Biomimetic Hydrogel Guided Functional Bone Regeneration by Adapting Material Degradation to Tissue Healing
Injectable Biomimetic Hydrogel Guided Functional Bone Regeneration by Adapting Material Degradation to Tissue Healing Open
The treatment of irregular bone defects remains a clinical challenge since the current biomaterials (e.g., calcium phosphate bone cement (CPC)) mainly act as inert substitutes, which are incapable of transforming into a regenerated host bo…