Changsong Wang
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View article: Plasma Proteome-Driven Liquid Biopsy for Individualized Monitoring and Risk Stratification of Immune-Related Adverse Events in Checkpoint Immunotherapy
Plasma Proteome-Driven Liquid Biopsy for Individualized Monitoring and Risk Stratification of Immune-Related Adverse Events in Checkpoint Immunotherapy Open
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, however, their use is limited by heterogeneous and unpredictable immune-related adverse events (irAEs), which can progress to life-threatening conditions requiring int…
View article: Intensive care unit outcomes and prognostic factors of colorectal cancer
Intensive care unit outcomes and prognostic factors of colorectal cancer Open
BACKGROUND Colorectal cancer (CRC) is one of the most common cancers and CRC patients are among the most common intensive care unit (ICU) admitted cancer patients. However, their prognosis and evaluation methods are rarely studied. AIM To …
View article: Survival predictors of lung cancer patients in ICU: the importance of acute kidney injury prediction and prevention
Survival predictors of lung cancer patients in ICU: the importance of acute kidney injury prediction and prevention Open
Background To identify potential predictors of short-term survival among patients with lung cancer admitted to the intensive care unit (ICU). Methods A multicenter longitudinal observational study of patients with lung cancer was conducted…
View article: Urinary 3-methylhistidine as a potential biomarker for sepsis-associated acute kidney injury: multidimensional metabolomics analysis in mice and human
Urinary 3-methylhistidine as a potential biomarker for sepsis-associated acute kidney injury: multidimensional metabolomics analysis in mice and human Open
Background Sepsis-associated acute kidney injury (SA-AKI) is strongly associated with increased mortality in critical patients. The early detection of SA-AKI is crucial for clinical intervention. This study aims to integrate multiple metab…
View article: Intensive care unit outcomes and prognostic factors of esophageal cancer: A cross-sectional study in Chinese cancer-specialized hospitals
Intensive care unit outcomes and prognostic factors of esophageal cancer: A cross-sectional study in Chinese cancer-specialized hospitals Open
BACKGROUND Esophageal cancer patients had the highest intensive care unit (ICU) admitted rate in cancer patients. But their prognosis and evaluation methods were rarely studied. AIM To depict the short-term mortality outcome and identify t…
View article: Mendelian randomization analysis reveals potential association between allergic rhinitis and nasopharyngeal carcinoma
Mendelian randomization analysis reveals potential association between allergic rhinitis and nasopharyngeal carcinoma Open
This comprehensive analysis provides detailed insights into the complex immune microenvironment and molecular mechanisms of NPC. The identification of distinct cellular populations, temporal patterns, and key molecular players offers valua…
View article: Trend analysis and prediction of disease burden of occupational carbon monoxide poisoning in China based on the past two decades
Trend analysis and prediction of disease burden of occupational carbon monoxide poisoning in China based on the past two decades Open
This study aims to analyse and predict the disease burden of occupational carbon monoxide (CO) poisoning in China and provide recommendations for its prevention and treatment. Based on the global disease burden2021 data, Joinpoint 5.0.2 so…
View article: Urine Neutrophil Elastase: A Novel Predictor of ICU Admission for Patients with COVID-19 Infection
Urine Neutrophil Elastase: A Novel Predictor of ICU Admission for Patients with COVID-19 Infection Open
Urine NE level is a useful predictor of COVID-19 progression, particularly in patients requiring ICU care. Urine NE has a significantly positive correlation with neutrophil%, DD, and PCT, as well as a negative correlation with lymphocyte l…
View article: Robotic <i>versus</i> laparoscopic hepatectomy: meta-analysis of propensity-score matched studies
Robotic <i>versus</i> laparoscopic hepatectomy: meta-analysis of propensity-score matched studies Open
Background Robotic techniques can theoretically overcome the limitations of laparoscopic liver resection and are currently recognized as safe options; however, it is not known which approach is better. The purpose of this study was to comp…
View article: InternVideo2.5: Empowering Video MLLMs with Long and Rich Context Modeling
InternVideo2.5: Empowering Video MLLMs with Long and Rich Context Modeling Open
This paper aims to improve the performance of video multimodal large language models (MLLM) via long and rich context (LRC) modeling. As a result, we develop a new version of InternVideo2.5 with a focus on enhancing the original MLLMs' abi…
View article: Which metabolites are removed by continuous renal replacement therapies: A prospective, observational, single-center study
Which metabolites are removed by continuous renal replacement therapies: A prospective, observational, single-center study Open
Background: Despite considerable research on the loss of inorganic substances in continuous renal replacement therapy (CRRT), no relevant experimental studies have been conducted to determine whether and how much organic matter is lost and…
View article: VideoChat-Flash: Hierarchical Compression for Long-Context Video Modeling
VideoChat-Flash: Hierarchical Compression for Long-Context Video Modeling Open
Long-context video modeling is critical for multimodal large language models (MLLMs), enabling them to process movies, online video streams, and so on. Despite its advances, handling long videos remains challenging due to the difficulty in…
View article: PAGE-based transfer learning from single-cell to bulk sequencing enhances model generalization for sepsis diagnosis
PAGE-based transfer learning from single-cell to bulk sequencing enhances model generalization for sepsis diagnosis Open
Sepsis, caused by infections, sparks a dangerous bodily response. The transcriptional expression patterns of host responses aid in the diagnosis of sepsis, but the challenge lies in their limited generalization capabilities. To facilitate …
View article: Integrated analysis of single-cell, spatial and bulk RNA-sequencing identifies a cell-death signature for predicting the outcomes of head and neck cancer
Integrated analysis of single-cell, spatial and bulk RNA-sequencing identifies a cell-death signature for predicting the outcomes of head and neck cancer Open
Background Cell death plays an essential role in carcinogenesis, but its function in the recurrence and postoperative prognosis of head and neck cancer (HNC), which ranks as the 7 th most common malignancy globally, remains unclear. Method…
View article: Causal Association Between Heart Failure and Sepsis: Insights from Mendelian Randomization and Observational Studies
Causal Association Between Heart Failure and Sepsis: Insights from Mendelian Randomization and Observational Studies Open
Observational and MR analyses showed a causal relationship between HF and sepsis. Chronic SCHF was related to increased short/long-term mortality in sepsis. Our study indicated βNGF a key factor in HF-induced sepsis.
View article: Comparison of the therapeutic effect of Paxlovid and Azvudine in the treatment of COVID-19: A retrospective study
Comparison of the therapeutic effect of Paxlovid and Azvudine in the treatment of COVID-19: A retrospective study Open
In assessing patient conditions for treatment selection, Paxlovid may be preferable for individuals with renal insufficiency or those exhibiting compromised immune responses. Conversely, for patients experiencing malnutrition or cirrhotic …
View article: From China to Malaysia: Understanding The Cultural and Economic Dynamics of Imported Chinese Films
From China to Malaysia: Understanding The Cultural and Economic Dynamics of Imported Chinese Films Open
The connection between China’s diplomatic engagements abroad and its trans-border film trade holds considerable importance. Inherent in this dynamic is cross-cultural interaction and inter-cultural communication. Malaysia’s support for Chi…
View article: Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models
Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models Open
In this study, we dynamically monitored the glomerular filtration rate and other assessment of renal function and markers of injury in various mice models of acute kidney injury. Male C57BL/6 mice were utilized to establish acute kidney in…
View article: Postoperative cognitive dysfunction in aged mice after sevoflurane inhalation: crosstalk of gut microbiota, metabolomics, and proteomics
Postoperative cognitive dysfunction in aged mice after sevoflurane inhalation: crosstalk of gut microbiota, metabolomics, and proteomics Open
Background: General anaesthesia, especially sevoflurane inhalation anaesthesia, is an independent risk factor for postoperative cognitive dysfunction. However, the molecular mechanism by which sevoflurane inhalation alters postoperative co…
View article: Throat microbiota drives alterations in pulmonary alveolar microbiota in patients with septic ARDS
Throat microbiota drives alterations in pulmonary alveolar microbiota in patients with septic ARDS Open
In patients with septic ARDS, the main source of lung microbiota is primarily from the throat. Furthermore, the dynamic trend of the microbiota on the first and third day is essentially consistent.It is important to note that the origin of…
View article: Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models
Dynamic changes in the real-time glomerular filtration rate and kidney injury markers in different acute kidney injury models Open
In this study, the dynamic changes in the real-time glomerular filtration rate in acute kidney injury models were monitored via percutaneous glomerular filtration rate monitoring technology. Male C57BL/6 mice were used to establish sepsis,…
View article: Reduced Viral Shedding Time in High-Risk COVID-19 Patients Infected by Omicron and Treated with Paxlovid: A Real-World Study from China
Reduced Viral Shedding Time in High-Risk COVID-19 Patients Infected by Omicron and Treated with Paxlovid: A Real-World Study from China Open
The CT value of the Paxlovid therapy group became negative more quickly. This finding suggests that Paxlovid treatment after early diagnosis of the Omicron variant may achieve good therapeutic efficacy.