Changying Xing
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View article: Systemic inflammation and B-cell indices predict rituximab responses in membranous nephropathy
Systemic inflammation and B-cell indices predict rituximab responses in membranous nephropathy Open
Introduction Membranous nephropathy (MN) is a frequent cause of nephrotic syndrome in adults with variable response to rituximab (RTX) therapy. While traditional markers like proteinuria and anti-PLA2R antibodies exhibit predictive value, …
View article: NIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects
NIR‐II Responsive Multifunctional Scaffold Enabling “Kill‐Modulation‐Build” Synergistic Therapy for Infectious Bone Defects Open
Infectious bone defects present dual challenges: eliminating bacteria and regenerating tissue, which are further complicated by biofilm formation, antibiotic resistance, and chronic inflammation. Here, a near‐infrared‐II (NIR‐II) responsiv…
View article: B cell and anti-PLA2R antibody-guided rituximab therapy in idiopathic membranous nephropathy: a prospective multi-center cohort study in the East Coastal Region of China
B cell and anti-PLA2R antibody-guided rituximab therapy in idiopathic membranous nephropathy: a prospective multi-center cohort study in the East Coastal Region of China Open
Introduction This study assessed the safety and efficacy of B cell- and anti-PLA2R antibody-targeted low-dose rituximab therapy in patients with idiopathic membranous nephropathy (IMN). Methods This was a multicenter, investigator-initiate…
View article: Effect of time-weighted average 25(OH)D on the occurrence of major adverse kidney events in IgA nephropathy—from a 10-year population-based cohort study
Effect of time-weighted average 25(OH)D on the occurrence of major adverse kidney events in IgA nephropathy—from a 10-year population-based cohort study Open
Background Vitamin D (VD) deficiency has been found to be common and associated with a higher risk of adverse outcomes in chronic kidney disease (CKD), according to certain studies. However, whether it is associated with the progression of…
View article: Probiotic <i>Akkermansia muciniphila</i> alleviates acute kidney injury by protecting the intestinal barrier and modulating gut microbiota and metabolites
Probiotic <i>Akkermansia muciniphila</i> alleviates acute kidney injury by protecting the intestinal barrier and modulating gut microbiota and metabolites Open
Acute kidney injury (AKI) is a critical condition with limited effective therapies. Akkermansia muciniphila ( A. muciniphila) is a probiotic with multiple beneficial effects, including epithelial cell tight junctions regulation. Since rena…
View article: Bromadiolone may cause severe acute kidney injury through severe disorder of coagulation: a case report
Bromadiolone may cause severe acute kidney injury through severe disorder of coagulation: a case report Open
Bromadiolone can induce AKI through a severe and prolonged coagulation disorder. Kidney function can be restored within days following treatment with high-dose vitamin K1.
View article: Predictive nomogram model for severe coronary artery calcification in end-stage kidney disease patients
Predictive nomogram model for severe coronary artery calcification in end-stage kidney disease patients Open
CAC is both prevalent and severe in ESKD patients. In the four branches of the coronary arteries, LAD calcification is the most common. Our validated nomogram model, based on clinical risk factors, can help predict the risk of severe coron…
View article: Fibrinogen-albumin ratio predicts treatment response in phospholipase A2 receptor-associated membranous nephropathy with nephrotic syndrome
Fibrinogen-albumin ratio predicts treatment response in phospholipase A2 receptor-associated membranous nephropathy with nephrotic syndrome Open
The M-type phospholipase A2 receptor (PLA2R)-associated primary membranous nephropathy (PMN) is an immune-related disease in adults with increasing morbidity and variable treatment response, in which inflammation may contribute to the mult…
View article: High sodium intake and fluid overhydration predict cardiac structural and functional impairments in chronic kidney disease
High sodium intake and fluid overhydration predict cardiac structural and functional impairments in chronic kidney disease Open
Background High sodium intake and fluid overhydration are common factors of and strongly associated with adverse outcomes in chronic kidney disease (CKD) patients. Yet, their effects on cardiac dysfunction remain unclear. Aims The study ai…
View article: #2389 Enhancing immunoglobulin A nephropathy management: insights from the IGAN-MIC project
#2389 Enhancing immunoglobulin A nephropathy management: insights from the IGAN-MIC project Open
Background and Aims Immunoglobulin A nephropathy (IgAN) comprises a substantial proportion of primary glomerulonephritis cases in China, yet comprehensive nationwide data regarding its diagnosis and treatment are lacking. The Immunoglobuli…
View article: Automated Electronic Alert for the Care and Outcomes of Adults With Acute Kidney Injury
Automated Electronic Alert for the Care and Outcomes of Adults With Acute Kidney Injury Open
Importance Despite the expansion of published electronic alerts for acute kidney injury (AKI), there are still concerns regarding their effect on the clinical outcomes of patients. Objective To evaluate the effect of the AKI alert combined…
View article: Association of Mitochondrial Pyruvate Carrier with the Clinical and Histological Features in Lupus Nephritis
Association of Mitochondrial Pyruvate Carrier with the Clinical and Histological Features in Lupus Nephritis Open
Both MPC1 and MPC2 were localized in renal tubules, and decreased MPC content was more pronounced in proliferative LN than membranous LN. MPC levels were significantly correlated with renal functions and renal pathology activity.
View article: Successful rescue of disseminated <i>Nocardia</i> infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation: A three-year follow-up
Successful rescue of disseminated <i>Nocardia</i> infection with multiple abscesses in a patient with membranous nephropathy after cardiopulmonary resuscitation: A three-year follow-up Open
Nocardiosis manifests as an opportunistic infection, primarily affecting individuals who are immunocompromised and susceptible to the infection. We present a case study of one patient with nephrotic syndrome and membranous nephropathy, who…
View article: A marked elevation in serum creatinine/cystatin C ratio may indicate pseudo-acute kidney injury due to urinary ascites: a case report and literature review
A marked elevation in serum creatinine/cystatin C ratio may indicate pseudo-acute kidney injury due to urinary ascites: a case report and literature review Open
Background Urinary ascites represents a scarcely observed pseudo-acute kidney injury in clinical settings. Protracted or missed diagnosis may hold grave ramifications for patient outcomes. Case presentation We reported a case involving an …
View article: Decoding the Intercellular Cross-Talking Between Immune Cells and Renal Innate Cells in Diabetic Kidney Disease by Bioinformatics
Decoding the Intercellular Cross-Talking Between Immune Cells and Renal Innate Cells in Diabetic Kidney Disease by Bioinformatics Open
Our study explored the pathogenesis of renal injury promoted by immunoinflammatory in DKD. VISTANT, SPP1, and IGF signaling pathways and SPP1-CD44, NRG1-ERBB4, NAMPT-INSR, and Igf1- Igf1r receptor ligand pairs might occupy essential place …
View article: Severe fluctuation in mean perfusion pressure is associated with increased risk of in-hospital mortality in critically ill patients with central venous pressure monitoring: A retrospective observational study
Severe fluctuation in mean perfusion pressure is associated with increased risk of in-hospital mortality in critically ill patients with central venous pressure monitoring: A retrospective observational study Open
Background The mean perfusion pressure (MPP) was recently proposed to personalize tissue perfusion pressure management in critically ill patients. Severe fluctuation in MPP may be associated with adverse outcomes. We sought to determine if…
View article: Therapeutic effects and mechanism of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient
Therapeutic effects and mechanism of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient Open
Calciphylaxis is a rare cutaneous vascular disease that manifests with intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and microvessel thrombosis. Currently, there are no…
View article: Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease
Relationships between blood bone metabolic biomarkers and anemia in patients with chronic kidney disease Open
Blood bone metabolic biomarkers are noninvasive indices for evaluating metabolic bone diseases. We investigated the relationships between blood bone metabolic biomarkers and anemia in chronic kidney disease (CKD) patients and analyzed the …
View article: Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis
Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis Open
Importance Baseline findings from the China Dialysis Calcification Study (CDCS) revealed a high prevalence of vascular calcification (VC) among patients with end-stage kidney disease; however, data on VC progression were limited. Objective…
View article: Serum 25-hydroxyvitamin D as a predictive biomarker of clinical outcomes in patients with primary membranous nephropathy
Serum 25-hydroxyvitamin D as a predictive biomarker of clinical outcomes in patients with primary membranous nephropathy Open
Background Primary membranous nephropathy (PMN) is an immune-related disease with increased morbidity and the most common cause of adult nephrotic syndrome (NS). The serum 25-hydroxyvitamin D [25(OH)D)], a biomarker of vitamin D (VD) statu…
View article: The thickness of glomerular basement membrane predicts complete remission in primary membranous nephropathy
The thickness of glomerular basement membrane predicts complete remission in primary membranous nephropathy Open
Glomerular basement membrane (GBM) thickening is a typical and essential histopathological characteristic for the diagnosis of primary membranous nephropathy (PMN). The present study aimed to explore the relationship between GBM thickness …
View article: Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient
Therapeutic effects of human amnion-derived mesenchymal stem cells on hypercoagulability in a uremic calciphylaxis patient Open
Calciphylaxis is a rare cutaneous vascular disease with clinical manifestations of intolerable pains, non-healing skin wounds, histologically characterized by calcification, fibrointimal hyperplasia, and thrombosis in microvessels. Current…
View article: Supplementary Material for: Efficacy and safety of ferric citrate on hyperphosphatemia among Chinese patients with chronic kidney disease undergoing hemodialysis: a phase III multicenter randomized open-label active-drug controlled study
Supplementary Material for: Efficacy and safety of ferric citrate on hyperphosphatemia among Chinese patients with chronic kidney disease undergoing hemodialysis: a phase III multicenter randomized open-label active-drug controlled study Open
Background: Hyperphosphatemia in CKD patients is positively associated with mortality. Ferric citrate is a potent phosphorus binder that lowers serum phosphorus level and improves iron metabolism. We compared its efficacy and safety with a…
View article: Relationship between blood bone metabolic biomarkers and anemia in CKD patients
Relationship between blood bone metabolic biomarkers and anemia in CKD patients Open
Introduction Blood bone metabolic biomarkers are non-invasive indexes for evaluating renal osteodystrophy (ROD). Here the relationships between blood bone metabolic biomarkers and anemia in chronic kidney disease (CKD) patients are investi…
View article: Increased mean perfusion pressure variability is associated with subsequent deterioration of renal function in critically ill patients with central venous pressure monitoring: a retrospective observational study
Increased mean perfusion pressure variability is associated with subsequent deterioration of renal function in critically ill patients with central venous pressure monitoring: a retrospective observational study Open
The mean perfusion pressure (MPP) was recently proposed to personalized management tissue perfusion pressure in critically ill patients. Increased MPP variability (MPPV) may be associated with organ injuries. Our objective was to determine…
View article: Clinicopathological features and individualized treatment of kidney involvement in B-cell lymphoproliferative disorder
Clinicopathological features and individualized treatment of kidney involvement in B-cell lymphoproliferative disorder Open
Background Due to the various clinical and pathological manifestations of kidney involvement in lymphoproliferative disorder (LPD), the whole spectrum of kidney disease in LPD is still unclear, and data on kidney prognosis is scarce. Metho…
View article: Effectiveness and safety of Belimumab combined with standard therapy in severe active lupus nephritis requiring kidney replacement therapy: A case report and literature review
Effectiveness and safety of Belimumab combined with standard therapy in severe active lupus nephritis requiring kidney replacement therapy: A case report and literature review Open
Lupus Nephritis (LN) is the most common manifestation of severe organ damage for systemic lupus erythematosus (SLE) patients. Severe active LN could result in acute kidney injury (AKI), which could even require Kidney Replacement Therapy (…
View article: Association of Serum 25 (OH) Vitamin D With Chronic Kidney Disease Progression in Type 2 Diabetes
Association of Serum 25 (OH) Vitamin D With Chronic Kidney Disease Progression in Type 2 Diabetes Open
Objectives Growing evidence demonstrated that vitamin D levels had been linked to type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) in light of various extraskeletal effects. Therefore, the present study aimed to evaluate th…
View article: Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis
Effect of Tacrolimus vs Intravenous Cyclophosphamide on Complete or Partial Response in Patients With Lupus Nephritis Open
ClinicalTrials.gov Identifier: NCT02457221.