Chen Dong
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View article: Twenty years of Th17: A dialogue on immunological innovation and translation
Twenty years of Th17: A dialogue on immunological innovation and translation Open
View article: Dysregulated NK cell activation and myeloid-lymphoid imbalance underpin COPD progression: insights from high-dimensional immune profiling and smoking-induced immune remodeling
Dysregulated NK cell activation and myeloid-lymphoid imbalance underpin COPD progression: insights from high-dimensional immune profiling and smoking-induced immune remodeling Open
Background Chronic obstructive pulmonary disease (COPD) is a significant global health concern, marked by persistent inflammation and immune dysregulation. Although it is widespread and has substantial clinical implications, the systemic i…
View article: Relationship between admission serum uric acid to lymphocyte ratio and the risk of ischemic stroke recurrence and death: a prospective study
Relationship between admission serum uric acid to lymphocyte ratio and the risk of ischemic stroke recurrence and death: a prospective study Open
This study demonstrates that higher ULR is significantly associated with an increased risk of recurrence and death following IS. The findings suggest that ULR could serve as a valuable prognostic marker in clinical practice, particularly i…
View article: IL4I1 attenuates myocardial infarction by inhibiting macrophage ferroptosis via the I3P/AHR/NRF2 signaling pathway
IL4I1 attenuates myocardial infarction by inhibiting macrophage ferroptosis via the I3P/AHR/NRF2 signaling pathway Open
We identify a novel cardioprotective axis wherein macrophage-derived IL4I1 catalyzes the production of I3P, activating AHR-NRF2 signaling to suppress ferroptosis, thereby mitigating post-MI inflammation, adverse remodeling, and cardiac dys…
View article: Urinary metabolite signatures to detect and differentiate graft injury in kidney transplant patients
Urinary metabolite signatures to detect and differentiate graft injury in kidney transplant patients Open
View article: Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy
Identification and experimental validation of mitochondrial and endoplasmic reticulum stress related gene in diabetic nephropathy Open
Diabetic nephropathy (DN) is a kidney disease. Mitochondrial and endoplasmic reticulum stress (ERS) significantly contribute to diabetic nephropathy (DN), although the precise mechanisms involved have not yet been fully understood. The obj…
View article: Itinerancy and Sojourn: Bai Yuchan’s Travels as the Early Dissemination History of Daoism’s Southern School
Itinerancy and Sojourn: Bai Yuchan’s Travels as the Early Dissemination History of Daoism’s Southern School Open
As the effective founder of Daoism’s Southern School, Bai Yuchan’s travels played a pivotal role in the sect’s early dissemination. Through a close analysis of his poems, prose, and letters, this study reconstructs the key itineraries and …
View article: Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13‐Year Longitudinal Cohort Study
Atmospheric Pollutants, Cardiometabolic Disorders, and Dementia in Trajectory Analysis: A 13‐Year Longitudinal Cohort Study Open
Background First cardiometabolic disorders (FCMDs) and dementia pose a significant burden on aging populations. Investigating the association between atmospheric pollutants and the progression of FCMDs and dementia is crucial. Methods A pr…
View article: Plasma proteomic profiles in diverse populations identify biomarkers predicting metabolic dysfunction-associated steatotic liver disease up to 16 years before onset
Plasma proteomic profiles in diverse populations identify biomarkers predicting metabolic dysfunction-associated steatotic liver disease up to 16 years before onset Open
Early identification of metabolic dysfunction-associated steatotic liver disease (MASLD) is crucial for preventing disease progression, yet reliable predictive tools remain lacking. We analyzed proteomics data of 37,966 participants withou…
View article: The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity
The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity Open
View article: Distraction is All You Need for Multimodal Large Language Model Jailbreaking
Distraction is All You Need for Multimodal Large Language Model Jailbreaking Open
Multimodal Large Language Models (MLLMs) bridge the gap between visual and textual data, enabling a range of advanced applications. However, complex internal interactions among visual elements and their alignment with text can introduce vu…
View article: TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation
TRIM28 is an essential regulator of three-dimensional chromatin state underpinning CD8+ T cell activation Open
View article: Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia
Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia Open
Background this study aimed to investigate the efficacy of recombinant human thrombopoietin (rhTPO) in the treatment of sepsis-associated thrombocytopenia, and to evaluate its impact on coagulation function, inflammatory markers, platelet …
View article: A human monoclonal antibody isolated from Japanese encephalitis virus vaccine-vaccinated volunteer neutralizing various flaviviruses
A human monoclonal antibody isolated from Japanese encephalitis virus vaccine-vaccinated volunteer neutralizing various flaviviruses Open
Introduction Japanese encephalitis virus (JEV) and Zika virus (ZIKV) are prevalent in over 80 countries or territories worldwide, causing hundreds of thousands of cases annually. But currently there is a lack of specific antiviral agents a…
View article: An engineered Japanese encephalitis virus mRNA-lipid nanoparticle immunization induces protective immunity in mice
An engineered Japanese encephalitis virus mRNA-lipid nanoparticle immunization induces protective immunity in mice Open
Introduction Japanese encephalitis virus (JEV) and Zika virus (ZIKV) pose a severe threat to human health. Our previous research results, as well as those of other research groups, indicated that antibodies (Abs) induced by JEV infection o…
View article: Association Between Weight-Adjusted Waist Index and Periodontitis: A Cross-Sectional Study and Mediation Analysis
Association Between Weight-Adjusted Waist Index and Periodontitis: A Cross-Sectional Study and Mediation Analysis Open
A higher WWI in Chinese adults was linked to an increased likelihood of periodontitis, and this correlation could be partially explained by elevated levels of TyG index-related indicators.
View article: Intimal sarcoma of the aortic valve and ascending aorta: a case report
Intimal sarcoma of the aortic valve and ascending aorta: a case report Open
Intimal sarcomas are an uncommon and extremely aggressive type of primary malignant aortic tumor. Diagnosis might be challenging and requires a high level of suspicion. Standard surgical treatment may include resection of the affected segm…
View article: The mediating role of serum 25-hydroxyvitamin D on the association between reduced sensitivity to thyroid hormones and periodontitis in Chinese euthyroid adults
The mediating role of serum 25-hydroxyvitamin D on the association between reduced sensitivity to thyroid hormones and periodontitis in Chinese euthyroid adults Open
Aim Thyroid dysfunction is closely associated with periodontitis. We aim to explore the association between sensitivity to thyroid hormones (THs) and periodontitis and to investigate the mediating role of serum 25-hydroxyvitamin D[25(OH)D]…
View article: Evaluation of the FPMC respiratory panel for detection of respiratory tract pathogens in nasopharyngeal swab and sputum specimens
Evaluation of the FPMC respiratory panel for detection of respiratory tract pathogens in nasopharyngeal swab and sputum specimens Open
View article: TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription
TRIM33 plays a critical role in regulating dendritic cell differentiation and homeostasis by modulating Irf8 and Bcl2l11 transcription Open
The development of distinct dendritic cell (DC) subsets, namely, plasmacytoid DCs (pDCs) and conventional DC subsets (cDC1s and cDC2s), is controlled by specific transcription factors. IRF8 is essential for the fate specification of cDC1s.…
View article: NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment
NR4A1 transcriptionally regulates the differentiation of stem-like CD8+ T cells in the tumor microenvironment Open
CD8+ T cells are rendered exhausted in tumor and chronic infection. Among heterogeneous exhausted T cells, a subpopulation of progenitor-like (Tpex) cells have been found important for long-term tumor or pathogen control and are…
View article: Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity Open
Chimeric antigen receptor (CAR) T cell immunotherapy for the treatment of neurological autoimmune diseases is promising, but CAR T cell kinetics and immune alterations after treatment are poorly understood. Here, we performed single-cell m…
View article: Japanese encephalitis virus E protein domain III immunization mediates cross-protection against Zika virus in mice via antibodies and CD8+ T cells
Japanese encephalitis virus E protein domain III immunization mediates cross-protection against Zika virus in mice via antibodies and CD8+ T cells Open
View article: Serum ferritin is associated with the presence of ischemic stroke among individuals with type 2 diabetes
Serum ferritin is associated with the presence of ischemic stroke among individuals with type 2 diabetes Open
View article: Association between thyroid indices and ischemic stroke: Glycated albumin as a mediator
Association between thyroid indices and ischemic stroke: Glycated albumin as a mediator Open
Limited data are available on the association between the thyroid indices and ischemic stroke (IS) risk, and the mechanisms remain unclear. We aimed to investigate the associations of thyroid indices and the prevalence of IS and examine th…
View article: BIRC6 Modulates the Protein Stability of Axin to Regulate the Growth, Stemness, and Resistance of Renal Cancer Cells via the β-Catenin Pathway
BIRC6 Modulates the Protein Stability of Axin to Regulate the Growth, Stemness, and Resistance of Renal Cancer Cells via the β-Catenin Pathway Open
The mechanism underlying the development of renal cell carcinoma (RCC) remains unclear, and effective prevention and therapeutic measures are lacking. BIRC6, a protein inhibitor of apoptosis, has attracted great interest. Our data indicate…
View article: A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer
A multiomics analysis-assisted deep learning model identifies a macrophage-oriented module as a potential therapeutic target in colorectal cancer Open
Colorectal cancer (CRC) is a common malignancy involving multiple cellular components. The CRC tumor microenvironment (TME) has been characterized well at single-cell resolution. However, a spatial interaction map of the CRC TME is still e…
View article: A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses
A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses Open
T follicular helper (Tfh) cells, essential for germinal center reactions, are not identical, with different phenotypes reported. Whether, when, and how they generate memory cells is still poorly understood. Here, through single-cell RNA-se…
View article: hLife: Linking basic research and clinical applications
hLife: Linking basic research and clinical applications Open
View article: Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors
Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitors Open
The evolutionarily conserved Notch pathway, involved in cancer stem cell capacity and cancer immunity, may predict the benefit from immune checkpoint inhibitors (ICIs) in clear cell renal cell carcinoma (ccRCC). In the TCGA dataset, mRNA e…