Changzhong Wang
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View article: Correction: Unveiling the NEFH+ malignant cell subtype: insights from single-cell RNA sequencing in prostate cancer progression and tumor microenvironment interactions
Correction: Unveiling the NEFH+ malignant cell subtype: insights from single-cell RNA sequencing in prostate cancer progression and tumor microenvironment interactions Open
[This corrects the article DOI: 10.3389/fimmu.2024.1517679.].
View article: Unveiling the NEFH+ malignant cell subtype: Insights from single-cell RNA sequencing in prostate cancer progression and tumor microenvironment interactions
Unveiling the NEFH+ malignant cell subtype: Insights from single-cell RNA sequencing in prostate cancer progression and tumor microenvironment interactions Open
Background Prostate cancer (PCa) is a multifactorial and heterogeneous disease, ranking among the most prevalent malignancies in men. In 2020, there were 1,414,259 new cases of PCa worldwide, accounting for 7.3% of all malignant tumors. Th…
View article: Sodium houttuyfonate induces bacterial lipopolysaccharide shedding to promote macrophage M1 polarization against acute bacterial lung infection
Sodium houttuyfonate induces bacterial lipopolysaccharide shedding to promote macrophage M1 polarization against acute bacterial lung infection Open
Sodium houttuyfonate (SH), derived from the widely utilized natural herb Houttuynia cordata, exhibits an effective therapeutic effect on various diseases, including bacterial and fungal infections, especially the respiratory tract infectio…
View article: Effects of the N-Butanol Extract of Pulsatilla Decoction on Neutrophils in a Mouse Model of Ulcerative Colitis
Effects of the N-Butanol Extract of Pulsatilla Decoction on Neutrophils in a Mouse Model of Ulcerative Colitis Open
Ulcerative colitis (UC) is a chronic inflammatory disease, the incidence of which is increasing worldwide. However, the etiology and pathogenesis of UC remains unclear. The n-butanol extract of Pulsatilla decoction (BEPD), a traditional Ch…
View article: Effects of the N-butanol Extract of Pulsatilla Decoction on Neutrophils in a Mouse Model of Ulcerative Colitis
Effects of the N-butanol Extract of Pulsatilla Decoction on Neutrophils in a Mouse Model of Ulcerative Colitis Open
Ulcerative colitis (UC) is a chronic inflammatory disease, the incidence of which is increasing worldwide. However, the etiology and pathogenesis of UC remains unclear. The n-butanol extract of pulsatilla decoction (BEPD) of the traditiona…
View article: Transcriptomics Reveals Effect of Pulsatilla Decoction Butanol Extract in Alleviating Vulvovaginal Candidiasis by Inhibiting Neutrophil Chemotaxis and Activation via TLR4 Signaling
Transcriptomics Reveals Effect of Pulsatilla Decoction Butanol Extract in Alleviating Vulvovaginal Candidiasis by Inhibiting Neutrophil Chemotaxis and Activation via TLR4 Signaling Open
The Pulsatilla decoction is a well-known herbal remedy used in clinical settings for treating vulvovaginal candidiasis (VVC). However, the specific mechanism that makes it effective is still unclear. Recent studies have shown that in cases…
View article: OBMI: oversampling borderline minority instances by a two-stage Tomek link-finding procedure for class imbalance problem
OBMI: oversampling borderline minority instances by a two-stage Tomek link-finding procedure for class imbalance problem Open
Mitigating the impact of class imbalance datasets on classifiers poses a challenge to the machine learning community. Conventional classifiers do not perform well as they are habitually biased toward the majority class. Among existing solu…
View article: A commentary on ‘Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: a meta-analysis with trial sequential analysis of randomized controlled trials’
A commentary on ‘Efficacy and safety of vitamin C for atrial fibrillation after cardiac surgery: a meta-analysis with trial sequential analysis of randomized controlled trials’ Open
aGraduate School of Tianjin University of Traditional Chinese Medicine,301600, Tianjin, China bSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 100105, Beijing, China cThe Second Affiliated Hospital of Tianjin Univ…
View article: Sodium Houttuyfonate Induces Bacterial Lipopolysaccharide Shedding to Promote Macrophage M1 Polarization Against Acute Bacterial Lung Infection
Sodium Houttuyfonate Induces Bacterial Lipopolysaccharide Shedding to Promote Macrophage M1 Polarization Against Acute Bacterial Lung Infection Open
View article: A Novel Uncertainty Measure with Relative Neighborhood for Multi-Density Data Reduction and Classification
A Novel Uncertainty Measure with Relative Neighborhood for Multi-Density Data Reduction and Classification Open
View article: Multi-scale Self-attention Recursive Hierarchical Network Based on Improved Residual Conv-LSTM
Multi-scale Self-attention Recursive Hierarchical Network Based on Improved Residual Conv-LSTM Open
Super-resolution Reconstruction (SR) refers to the process of obtaining high resolution (HR) images from low resolution (LR) images. In recent years, with the vigorous development of deep learning, SR technology has been more widely applie…
View article: Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies
Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies Open
Background Ulcerative colitis (UC) is a common type of inflammatory bowel disease. Due to the elusive pathogenesis, safe and effective treatment strategies are still lacking. Fraxini Cortex (FC) has been widely used as a medicinal herb to …
View article: The effect of herbal medicine in innate immunity to Candida albicans
The effect of herbal medicine in innate immunity to Candida albicans Open
Candida albicans ( C. albicans ) is an opportunistic pathogenic fungus that often causes mucosal and systemic infections. Several pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), …
View article: Additional file 2 of Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies
Additional file 2 of Deciphering the pharmacological mechanisms of Fraxini Cortex for ulcerative colitis treatment based on network pharmacology and in vivo studies Open
Additional file 2: Table S1. Active compounds of Fraxini Cortex. Table S2. Predicted targets of the Fraxini Cortex compounds. Table S3. The hub genes enriched in biological processes. Table S4. The hub genes enriched in cellular components…
View article: Characterization of the dynamic mechanical properties of low-iron float glass through Split-Hopkinson-Pressure-Bar tests
Characterization of the dynamic mechanical properties of low-iron float glass through Split-Hopkinson-Pressure-Bar tests Open
View article: HS-Gen: a hypersphere-constrained generation mechanism to improve synthetic minority oversampling for imbalanced classification
HS-Gen: a hypersphere-constrained generation mechanism to improve synthetic minority oversampling for imbalanced classification Open
Mitigating the impact of class-imbalance data on classifiers is a challenging task in machine learning. SMOTE is a well-known method to tackle this task by modifying class distribution and generating synthetic instances. However, most of t…
View article: Sodium houttuyfonate effectively treats acute pulmonary infection of Pseudomonas aeruginosa by affecting immunity and intestinal flora in mice
Sodium houttuyfonate effectively treats acute pulmonary infection of Pseudomonas aeruginosa by affecting immunity and intestinal flora in mice Open
Introduction Pseudomonas aeruginosa is a major nosocomial pathogen that frequently causes ventilator-associated pneumonia in specific populations. Sodium houttuyfonate (SH) has shown mild antibacterial activity against P. aeruginosa in vit…
View article: Deciphering the pharmacological mechanisms of Fraxini Cortex on ulcerative colitis treatment based on Network pharmacology and in vivo studies
Deciphering the pharmacological mechanisms of Fraxini Cortex on ulcerative colitis treatment based on Network pharmacology and in vivo studies Open
Background Ulcerative colitis (UC) is a common type of inflammatory bowel disease. Due to the elusive pathogenesis, safe and effective treatment strategies are still lacking. Fraxini Cortex (FC) has been widely used as a medicinal herb to …
View article: A Novel Multi-attention Fusion Convolution Neural Network for Blind Image Quality Assessment
A Novel Multi-attention Fusion Convolution Neural Network for Blind Image Quality Assessment Open
As an underlying computer vision task, blind image quality assessment plays an important role in image evaluation. According to the Human Vision System (HVS), when observing an image, people's visual attention will be more sensitive to the…
View article: Targeting Virulence Factors of Candida albicans with Natural Products
Targeting Virulence Factors of Candida albicans with Natural Products Open
Natural products derived from natural resources, including nutritional functional food, play an important role in human health. In recent years, the study of anti-fungal and other properties of agri-foods and derived functional compounds h…
View article: Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells
Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells Open
Vulvovaginal candidiasis (VVC) is an inflammatory disease of the vagina mainly caused by Candida albicans ( C. albicans ), which affects around three-quarters of all women during their reproductive age. Although some antifungal drugs such …
View article: Sodium houttuyfonate enhances the mono-therapy of fluconazole on oropharyngeal candidiasis (OPC) through HIF-1α/IL-17 axis by inhibiting cAMP mediated filamentation in <i>Candida albicans-Candida glabrata</i> dual biofilms
Sodium houttuyfonate enhances the mono-therapy of fluconazole on oropharyngeal candidiasis (OPC) through HIF-1α/IL-17 axis by inhibiting cAMP mediated filamentation in <i>Candida albicans-Candida glabrata</i> dual biofilms Open
Candida albicans and Candida glabrata are two common opportunistic fungi that can be co-isolated in oropharyngeal candidiasis (OPC). Hypha is a hallmark of the biofilm formation of C. albicans, indispensable for the at…
View article: No-reference image quality assessment with multi-scale weighted residuals and channel attention mechanism
No-reference image quality assessment with multi-scale weighted residuals and channel attention mechanism Open
Image is an important information source for human perception and machine pattern recognition. Image quality determines the accuracy and sufficiency of the information obtained. With the rapid development of deep learning in image processi…
View article: A Soft Neighborhood Rough Set Model and its Applications
A Soft Neighborhood Rough Set Model and its Applications Open
View article: Attention-Driven Residual-Dense Network for No-Reference Image Quality Assessment
Attention-Driven Residual-Dense Network for No-Reference Image Quality Assessment Open
View article: Systems pharmacology and transcriptomics reveal the mechanisms of Sanhuang decoction enema in the treatment of ulcerative colitis with additional Candida albicans infection
Systems pharmacology and transcriptomics reveal the mechanisms of Sanhuang decoction enema in the treatment of ulcerative colitis with additional Candida albicans infection Open
View article: Sodium Houttuyfonate and Sodium New Houttuyfonate Affect the Composition of Gut Microbiota and Production of Inflammatory Factors in Mice
Sodium Houttuyfonate and Sodium New Houttuyfonate Affect the Composition of Gut Microbiota and Production of Inflammatory Factors in Mice Open
Houttuynia drugs, including sodium houttuyfonate (SH) and sodium new houttuyfonate (SNH), are derivatives of the active ingredient of Houttuynia cordata, which can be used as both a vegetable and medicine in China. We aimed to explore the …
View article: Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors of Pseudomonas aeruginosa Controlled by Quorum Sensing
Sodium New Houttuyfonate Affects Transcriptome and Virulence Factors of Pseudomonas aeruginosa Controlled by Quorum Sensing Open
As a major opportunistic pathogen, Pseudomonas aeruginosa can produce various virulence factors and form biofilms. These processes are controlled by the quorum sensing (QS) system. Sodium new houttuyfonate (SNH) is an adduct of hout…
View article: Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq
Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq Open
Here, we aim to investigate the antifungal effect and mechanism of action of sodium new houttuyfonate (SNH) against Candida albicans. Microdilution analysis results showed that SNH possesses potent inhibitory activity against C. …
View article: Effects of sodium houttuyfonate on transcriptome of Pseudomonas aeruginosa
Effects of sodium houttuyfonate on transcriptome of Pseudomonas aeruginosa Open