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View article: A study combining microbubble-mediated focused ultrasound and radiation therapy in the healthy rat brain and a F98 glioma model
A study combining microbubble-mediated focused ultrasound and radiation therapy in the healthy rat brain and a F98 glioma model Open
Focused Ultrasound (FUS) has been shown to sensitize tumors outside the brain to Radiotherapy (RT) through increased ceramide-mediated apoptosis. This study investigated the effects of FUS + RT in healthy rodent brains and F98 gliomas. Tum…
View article: Transferrin Receptor‐Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation
Transferrin Receptor‐Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation Open
Microbubbles (MB) are widely used for ultrasound (US) imaging and drug delivery. MB are typically spherically shaped, due to surface tension. When heated above their glass transition temperature, polymer‐based MB can be mechanically stretc…
View article: Nonspherical ultrasound microbubbles
Nonspherical ultrasound microbubbles Open
Surface tension provides microbubbles (MB) with a perfect spherical shape. Here, we demonstrate that MB can be engineered to be nonspherical, endowing them with unique features for biomedical applications. Anisotropic MB were generated via…
View article: Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma
Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma Open
Effective chemotherapy delivery for glioblastoma multiforme (GBM) is limited by drug transport across the blood–brain barrier and poor efficacy of single agents. Polymer–drug conjugates can be used to deliver drug combinations with a ratio…
View article: Ultrasound-mediated blood-brain barrier disruption improves anti-pyroglutamate3 Aβ antibody efficacy and enhances phagocyte infiltration into brain in aged Alzheimer’s disease-like mice
Ultrasound-mediated blood-brain barrier disruption improves anti-pyroglutamate3 Aβ antibody efficacy and enhances phagocyte infiltration into brain in aged Alzheimer’s disease-like mice Open
Pyroglutamate-3 amyloid-β (pGlu3 Aβ) is an N-terminally modified, toxic form of amyloid-β that is present in cerebral amyloid plaques and vascular deposits. Using the Fc-competent murine anti-pGlu3 Aβ monoclonal antibody (mAb), 07/2a, we p…
View article: Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model
Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model Open
The blood-brain barrier (BBB) restricts delivery of most chemotherapy agents to brain tumors. Here, we investigated a clinical focused ultrasound (FUS) device to disrupt the BBB in rats and enhance carboplatin delivery to the brain using t…
View article: Noninvasive targeted neuromodulation and functional imaging in behaving macaques
Noninvasive targeted neuromodulation and functional imaging in behaving macaques Open
All presently available neural stimulation methods are either invasive or can only be moderately localized, and a neurostimulation method that could overcome these limitations would be invaluable for the mapping of brain circuits, disease …
View article: Feasibility of ablating brain regions adjacent to the optic nerve while retaining nerve function with focused ultrasound combined with an ultrasound contrast agent
Feasibility of ablating brain regions adjacent to the optic nerve while retaining nerve function with focused ultrasound combined with an ultrasound contrast agent Open
The goal of this work will be to investigate the safety of ablating tissue with focused ultrasound adjacent to peripheral nerves or to nerve tracts in the brain. We propose experiments in which we ablate tissue adjacent to the sciatic nerv…
View article: Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model
Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model Open
Significance Focused ultrasound is currently the only method of reversible blood–brain barrier disruption for targeted drug delivery without incision or radiation. A significant challenge for its clinical translation is a lack of reliable …