Chansavath Phetsouphanh
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View article: Expanded CD16+CD56+Granzyme B+ NK like CD8+ T cells an off target effect of bruton’s tyrosine kinase inhibitors in Waldenström macroglobulinemia
Expanded CD16+CD56+Granzyme B+ NK like CD8+ T cells an off target effect of bruton’s tyrosine kinase inhibitors in Waldenström macroglobulinemia Open
Bruton's tyrosine kinase inhibitors (BTKi), widely used in Waldenström macroglobulinemia (WM), are known to impair B cell function, but their broader immunological effects remain unclear. We investigated the T cell compartment in patients …
View article: Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection
Improvement of immune dysregulation in individuals with long COVID at 24-months following SARS-CoV-2 infection Open
This study investigates the humoral and cellular immune responses and health-related quality of life measures in individuals with mild to moderate long COVID (LC) compared to age and gender matched recovered COVID-19 controls (MC) over 24 …
View article: Modelling long COVID using Bayesian networks
Modelling long COVID using Bayesian networks Open
Motivated by the ambiguity of operational case definitions for long COVID and the impact of the lack of a common causal language on long COVID research, in early 2023 we began developing a research framework on this post-acute infection sy…
View article: Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment
Deficiency of factor-inhibiting HIF creates a tumor-promoting immune microenvironment Open
Hypoxia signaling influences tumor development through both cell-intrinsic and -extrinsic pathways. Inhibiting hypoxia-inducible factor (HIF) function has recently been approved as a cancer treatment strategy. Hence, it is important to und…
View article: Improvement of immune dysregulation and health-related quality of life in individuals with long COVID at 24-months following SARS-CoV-2 infection
Improvement of immune dysregulation and health-related quality of life in individuals with long COVID at 24-months following SARS-CoV-2 infection Open
This study investigated the humoral and cellular immune responses in individuals with long COVID (LC) compared to age and gender matched recovered COVID-19 controls (MC) over 24-months. LC participants showed elevated spike and nucleocapsi…
View article: Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma
Tumor monocyte content predicts immunochemotherapy outcomes in esophageal adenocarcinoma Open
View article: The kynurenine pathway relates to post‐acute<scp>COVID</scp>‐19 objective cognitive impairment and<scp>PASC</scp>
The kynurenine pathway relates to post‐acute<span>COVID</span>‐19 objective cognitive impairment and<span>PASC</span> Open
Objective To determine the prevalence and natural history of post‐acute COVID‐19 objective cognitive impairment and function, and their relationship to demographic, clinical factors, post‐acute sequelae of COVID‐19 (PASC), and biomarkers. …
View article: Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19
Tracking the clonal dynamics of SARS-CoV-2-specific T cells in children and adults with mild/asymptomatic COVID-19 Open
View article: High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells
High titre neutralizing antibodies in response to SARS–CoV–2 infection require RBD–specific CD4 T cells that include proliferative memory cells Open
Background Long-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden. Methods We have invest…
View article: High titre neutralizing antibodies in response to SARS-CoV-2 infection require RBD-specific CD4 T cells that include proliferative memory cells
High titre neutralizing antibodies in response to SARS-CoV-2 infection require RBD-specific CD4 T cells that include proliferative memory cells Open
Long-term immunity to SARS-CoV-2 infection, including neutralizing antibodies and T cell-mediated immunity, is required in a very large majority of the population in order to reduce ongoing disease burden. We have investigated the associat…
View article: Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study
Post-acute COVID-19 cognitive impairment and decline uniquely associate with kynurenine pathway activation: a longitudinal observational study Open
Cognitive impairment and function post-acute mild to moderate COVID-19 are poorly understood. We report findings of 128 prospectively studied SARS-CoV-2 positive patients. Cognition and olfaction were assessed at 2-, 4- and 12-months post-…
View article: PB2087: EFFICACY OF A 3RD COVID VACCINE, INCLUDING DURING A BTKI PAUSE, IN INDIVIDUALS WITH WALDENSTRÖM MACROGLOBULINEMIA AND FOLLICULAR LYMPHOMA
PB2087: EFFICACY OF A 3RD COVID VACCINE, INCLUDING DURING A BTKI PAUSE, IN INDIVIDUALS WITH WALDENSTRÖM MACROGLOBULINEMIA AND FOLLICULAR LYMPHOMA Open
Background: Patients (pts) with indolent lymphomas are at increased risk of severe COVID-19 infection. We have shown limited seroconversion and live viral neutralisation (VN), but preserved COVID-specific T cell responses after 2 doses of …
View article: Patients with treated indolent lymphomas immunized with <scp>BNT162b2</scp> have reduced anti‐spike neutralizing <scp>IgG</scp> to <scp>SARS‐CoV</scp>‐2 variants, but preserved antigen‐specific T cell responses
Patients with treated indolent lymphomas immunized with <span>BNT162b2</span> have reduced anti‐spike neutralizing <span>IgG</span> to <span>SARS‐CoV</span>‐2 variants, but preserved antigen‐specific T cell responses Open
Patients with indolent lymphoma undertaking recurrent or continuous B cell suppression are at risk of severe COVID‐19. Patients and healthy controls (HC; N = 13) received two doses of BNT162b2: follicular lymphoma (FL; N = 35) who were tre…
View article: Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19
Clonal dynamics of SARS-CoV-2-specific T cells in children and adults with COVID-19 Open
SUMMARY Children infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) develop less severe coronavirus disease 2019 (COVID-19) than adults. The mechanisms for the age-specific differences and the implications for infec…
View article: Myocardial fibrosis occurs in non-hospitalised patients with chronic symptoms after COVID-19
Myocardial fibrosis occurs in non-hospitalised patients with chronic symptoms after COVID-19 Open
View article: Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses
Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses Open
View article: Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection Open
View article: Efficacy of Vaccine BNT162b2 (Pfizer-BioNTech) in Individuals with Waldenstrom's Macroglobulinemia and Follicular Lymphoma in Australia
Efficacy of Vaccine BNT162b2 (Pfizer-BioNTech) in Individuals with Waldenstrom's Macroglobulinemia and Follicular Lymphoma in Australia Open
Introduction Lymphoid malignancies are a risk factor for severe COVID-19. Vaccination with BNT162b2 protects the general population from severe disease, but recent studies have shown limited seroconversion after vaccination in patients wit…
View article: Immunological dysfunction persists for 8 months following initial mild-moderate SARS-CoV-2 infection
Immunological dysfunction persists for 8 months following initial mild-moderate SARS-CoV-2 infection Open
A proportion of patients surviving acute COVID-19 infection develop post-COVID syndrome (long COVID) encompassing physical and neuropsychiatric symptoms lasting longer than 12 weeks. Here we studied a prospective cohort of individuals with…
View article: Long-term and short-term immunity to SARS-CoV-2: why it matters
Long-term and short-term immunity to SARS-CoV-2: why it matters Open
The adaptive immune system, regulated by CD4 T cells, is essential for control of many viral infections. Endemic coronavirus infections generally occur as short-term upper respiratory tract infections which in many cases appear to be clear…
View article: CD73+ CD127high Long-Term Memory CD4 T Cells Are Highly Proliferative in Response to Recall Antigens and Are Early Targets in HIV-1 Infection
CD73+ CD127high Long-Term Memory CD4 T Cells Are Highly Proliferative in Response to Recall Antigens and Are Early Targets in HIV-1 Infection Open
HIV-1 infection rapidly leads to a loss of the proliferative response of memory CD4+ T lymphocytes, when cultured with recall antigens. We report here that CD73 expression defines a subset of resting memory CD4+ T cells in peripheral blood…
View article: Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses
Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses Open
View article: Author response: Human MAIT cells respond to and suppress HIV-1
Author response: Human MAIT cells respond to and suppress HIV-1 Open
View article: Characterizing Hepatitis C Virus–Specific CD4+ T Cells Following Viral‐Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure
Characterizing Hepatitis C Virus–Specific CD4+ T Cells Following Viral‐Vectored Vaccination, Directly Acting Antivirals, and Spontaneous Viral Cure Open
Background and Aims Induction of functional helper CD4 + T cells is the hallmark of a protective immune response against hepatitis C virus (HCV), associated with spontaneous viral clearance. Heterologous prime/boost viral vectored vaccinat…
View article: Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers
Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers Open
Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages. Additionally, HIV-specific cytolytic CD4+ T cell r…
View article: Maintenance of Functional CD57+Cytolytic CD4+T Cells in HIV plus Elite Controllers
Maintenance of Functional CD57+Cytolytic CD4+T Cells in HIV plus Elite Controllers Open
View article: CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype
CD32 expressing doublets in HIV-infected gut-associated lymphoid tissue are associated with a T follicular helper cell phenotype Open
View article: Increased monocyte activation with age among <scp>HIV</scp>‐infected long term non‐progressor children: implications for early treatment initiation
Increased monocyte activation with age among <span>HIV</span>‐infected long term non‐progressor children: implications for early treatment initiation Open
Objectives The key to newer therapeutic and eradication approaches often lies in understanding slow disease progression in HIV infection. The paediatric population has been poorly studied in this regard. We aimed to describe a cohort of pe…
View article: Single-cell transcriptome analysis of CD8+ T-cell memory inflation
Single-cell transcriptome analysis of CD8+ T-cell memory inflation Open
Background: Persistent viruses such as murine cytomegalovirus (MCMV) and adenovirus-based vaccines induce strong, sustained CD8+ T-cell responses, described as memory “inflation”. These retain functionality, home to peripheral organs and a…
View article: CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA
CD32-Expressing CD4 T Cells Are Phenotypically Diverse and Can Contain Proviral HIV DNA Open
Efforts to both characterize and eradicate the HIV reservoir have been limited by the rarity of latently infected cells and the absence of a specific denoting biomarker. CD32a (FcγRIIa) has been proposed to be a marker for an enriched CD4 …