Explanipedia

Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM‐1 cell adhesion molecules Open

Pierre‐Michaël Coly, Shruti Chatterjee, Fariza Mezine, Christelle El Jekmek, Cécile Devue , et al. · 2024

Atherosclerotic lesions mainly form in arterial areas exposed to low shear stress (LSS), where endothelial cells express a senescent and inflammatory phenotype. Conversely, areas exposed to high shear stress (HSS) are protected from plaque…

Endothelial autophagy is not required for liver regeneration after partial hepatectomy in mice with fatty liver Open

Adel Hammoutène, Marion Tanguy, Mélanie Calmels, Riccardo Pravisani, Miguel Albuquerque , et al. · 2023

Background & Aims Patients with non‐alcoholic fatty liver disease (NAFLD) have impaired liver regeneration. Liver endothelial cells play a key role in liver regeneration. In non‐alcoholic steatohepatitis (NASH), liver endothelial cells dis…

Atheroprone shear stress stimulates noxious endothelial extracellular vesicle uptake by MCAM and PECAM-1 cell adhesion molecules Open

Pierre‐Michaël Coly, Shruti Chatterjee, Fariza Mezine, Christelle El Jekmek, Cécile Devue , et al. · 2023

Atherosclerotic lesions mainly form in arterial areas exposed to low shear stress (LSS), where endothelial cells express a senescent and inflammatory phenotype. Conversely, high shear stress (HSS) has atheroprotective effects on the endoth…

Low grade intravascular hemolysis associates with peripheral nerve injury in type 2 diabetes Open

Sylvain Le Jeune, Sihem Sadoudi, Dominique Charue, Salwa Abid, Jean‐Michel Guigner , et al. · 2022

Type 2 diabetes (T2D) induces hyperglycemia, alters hemoglobin (Hb), red blood cell (RBC) deformability and impairs hemorheology. The question remains whether RBC breakdown and intravascular hemolysis (IVH) occur in T2D patients. We charac…

Increased Circulating CD62E+ Endothelial Extracellular Vesicles Predict Severity and in- Hospital Mortality of COVID-19 Patients Open

Fariza Mezine, Coralie L. Guérin, Aurélien Philippe, Nicolas Gendron, Lou Soret , et al. · 2022

Methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles Open

Sean M. Davidson, Chantal M. Boulanger, Elena Aïkawa, Lina Badimón, Lucio Barile , et al. · 2022

Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from cells of the cardiovascular system, and are considered important mediators of intercellular and extracellular communications. Two types of EVs …

Les vésicules extracellulaires dans les pathologies cardiovasculaires Open

Laurent‐Emmanuel Monfoulet, Chantal M. Boulanger · 2022

National audience

Vésicules extracellulaires et microscopie électronique : un duo indissociable ! Open

Chantal M. Boulanger, Christelle Blavignac · 2022

National audience

Le mot des coordinatrices Open

Chantal M. Boulanger, Graça Raposo, Clotilde Théry · 2021

The power of imaging to understand extracellular vesicle biology in vivo Open

Frederik J. Verweij, Leonora Balaj, Chantal M. Boulanger, David R. F. Carter, Ewoud B. Compeer , et al. · 2021

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation Open

Natalia Reglero-Real, Lorena Pérez, Azumi Yoshimura, Loïc Rolas, José Garrido‐Mesa , et al. · 2021

POS0067 HIGH DEGREE OF INTER-PATIENT HETEROGENEITY IN SYNOVIOCYTE HYPERPLASIA AND IMMUNE CELLS INFILTRATION IN THE SYNOVIUM OF JUVENILE IDIOPATHIC ARTHRITIS PATIENTS Open

Clément Triaille, Chantal M. Boulanger, T. Sokolova, Laurent Méric de Bellefon, A. Nzeusseu Toukap , et al. · 2021

Messages from the heart Open

Chantal M. Boulanger, Xavier Loyer, Pierre‐Michaël Coly, Nicolas Amabile · 2021

à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

Restoring vascular endothelial autophagic flux reduces atherosclerotic lesions Open

Shruti Chatterjee, Marouane Kheloufi, Stephane Mazlan, Xavier Loyer, Timothy A. McKinsey , et al. · 2021

Atherosclerotic lesions preferentially develop in arterial areas exposed to low shear stress, where endothelial cells express a pro-inflammatory, apoptotic, and senescent phenotype. Endothelial cells exposed to atheroprone low shear stress…

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Open

Clotilde Théry, Kenneth W. Witwer, Elena Aïkawa, María José Alcaraz, Johnathon D. Anderson , et al. · 2021

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell-released, membranou…

Analysis of Neat Biofluids Obtained During Cardiac Surgery Using Nanoparticle Tracking Analysis: Methodological Considerations Open

Andrew I.U. Shearn, Sezin Aday, Soumaya Ben‐Aicha, Pauline Carnell-Morris, Agnieszka Siupa , et al. · 2020

Small extracellular vesicles (sEVs) are those nanovesicles 30-150 nm in size with a role in cell signalling and potential as biomarkers of disease. Nanoparticle tracking analysis (NTA) techniques are commonly used to measure sEV concentrat…

Erythrocyte-derived microvesicles induce arterial spasms in JAK2V617F myeloproliferative neoplasm Open

Johanne Poisson, Marion Tanguy, Hortense Davy, Fatoumata Camara, Marie-Belle El Mdawar , et al. · 2020

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant…

Tribute to Paul M. Vanhoutte, MD, PhD (1940–2019) Open

Chantal M. Boulanger, Oliver Baretella, Gilbert Blaise, Richard A. Bond, Yin Cai , et al. · 2019

Long Noncoding RNA-Enriched Vesicles Secreted by Hypoxic Cardiomyocytes Drive Cardiac Fibrosis Open

Franziska Kenneweg, Claudia Bang, Ke Xiao, Chantal M. Boulanger, Xavier Loyer , et al. · 2019

Extracellular Mitochondria and Vesicles Open

Pierre‐Michaël Coly, Chantal M. Boulanger · 2019

International audience

Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence‐tagged vesicles as biological reference material Open

André Görgens, Michel Bremer, Rita Ferrer-Tur, Florian Murke, Tobias Tertel , et al. · 2019

Extracellular vesicles (EVs) mediate targeted cellular interactions in normal and pathophysiological conditions and are increasingly recognised as potential biomarkers, therapeutic agents and drug delivery vehicles. Based on their size and…

Highlight on Endothelial Activation and Beyond Open

Chantal M. Boulanger · 2018

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines Open

Clotilde Théry, Kenneth W. Witwer, Elena Aïkawa, María José Alcaraz, Johnathon D. Anderson , et al. · 2018

The last decade has seen a sharp increase in the number of scientific publications describing physiological and pathological functions of extracellular vesicles (EVs), a collective term covering various subtypes of cell‐released, membranou…

Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction Open

Xavier Loyer, Ivana Zlatanova, Cécile Devue, Min Yin, Kiave-Yune HoWangYin , et al. · 2018

Rationale: A rapid and massive influx of inflammatory cells occurs into ischemic area after myocardial infarction (MI), resulting in local release of cytokines and growth factors. Yet, the mechanisms regulating their production are not ful…

Cardiovascular Research in France Open

Chantal M. Boulanger, Jean‐Sébastien Silvestre, Alain Tedgui · 2018

Les aventures de Pierre Théberge Open

Chantal M. Boulanger · 2018

Endothelial autophagic flux hampers atherosclerotic lesion development Open

Marouane Kheloufi, Anne-Clémence Vion, Adel Hammoutène, Johanne Poisson, Juliette Lasselin , et al. · 2017

Blood flowing in arteries generates shear forces at the surface of the vascular endothelium that control its anti-atherogenic properties. However, due to the architecture of the vascular tree, these shear forces are heterogeneous and ather…

Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology Open

Joost P. G. Sluijter, Sean M. Davidson, Chantal M. Boulanger, E I Buzas, Dominique Paschalis Victor de Kleijn , et al. · 2017

Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulat…

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow Open

Anne-Clémence Vion, Marouane Kheloufi, Adel Hammoutène, Johanne Poisson, Juliette Lasselin , et al. · 2017

Significance Atherosclerotic plaques tend to develop preferentially in areas of the vasculature exposed to low and disturbed shear stress (SS), but the mechanisms are not fully understood. In this study, we demonstrate that inefficient aut…

Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a Open

Henry S. Cheng, Rickvinder Besla, Angela Li, Zhiqi Chen, Eric A. Shikatani , et al. · 2017

Rationale: Inflammation is a key contributor to atherosclerosis. MicroRNA-146a (miR-146a) has been identified as a critical brake on proinflammatory nuclear factor κ light chain enhancer of activated B cells signaling in several cell types…

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