Marc Simard
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View article: Polypharmacy Thresholds that Best Predict Emergency Room Visits and Mortality in Older Adults: A Population-Based Study in Québec, Canada
Polypharmacy Thresholds that Best Predict Emergency Room Visits and Mortality in Older Adults: A Population-Based Study in Québec, Canada Open
Background Polypharmacy is prevalent among older adults. Identifying informative medication thresholds could enhance clinical decision-making and healthcare planning. Objectives To measure the predictive capacity of medication count and po…
View article: Combined impact of the COVID-19 pandemic and the number of comorbidities on community antibiotic utilisation rates: a population-based retrospective cohort study using linked health administrative data in Quebec, Canada
Combined impact of the COVID-19 pandemic and the number of comorbidities on community antibiotic utilisation rates: a population-based retrospective cohort study using linked health administrative data in Quebec, Canada Open
Objectives To describe community antibiotic utilisation in Quebec from 2018 to 2022 and to measure the combined impact of the COVID-19 pandemic and of the number of comorbidities on utilisation rates. Methods Data from the Quebec Integrate…
View article: Trends in medication use during the COVID-19 pandemic in Quebec, Canada
Trends in medication use during the COVID-19 pandemic in Quebec, Canada Open
The COVID-19 pandemic has disrupted health and services worldwide. We aimed to describe the changes in medication use during the COVID-19 pandemic in Quebec, Canada. Using a large healthcare database, we created weekly cohorts of all indiv…
View article: Polypharmacy and frequently used medications before death in Qc: any differences between persons with and without dementia?
Polypharmacy and frequently used medications before death in Qc: any differences between persons with and without dementia? Open
CONTEXT: Few studies have looked at polypharmacy and frequently used medications in the last months of life of persons with dementia (PWD), where the benefits of some medications are uncertain. We still do not know to which extent the medi…
View article: Association between number of medications and indicators of potentially inappropriate polypharmacy: a population-based cohort of older adults in Quebec, Canada
Association between number of medications and indicators of potentially inappropriate polypharmacy: a population-based cohort of older adults in Quebec, Canada Open
Background: As the number of medications increases, the appropriateness of polypharmacy may become questionable due to the heightened risk of medication-related harm. Objectives: (1) To investigate the relationship between the number of cu…
View article: Traditional Methods Hold Their Ground Against Machine Learning in Predicting Potentially Inappropriate Medication Use in Older Adults
Traditional Methods Hold Their Ground Against Machine Learning in Predicting Potentially Inappropriate Medication Use in Older Adults Open
Including other types of predictors (eg, unstructured data) may be more useful for increasing performance in prediction of potentially inappropriate medication use.
View article: Multimorbidity prevalence and health outcome prediction: assessing the impact of lookback periods, disease count, and definition criteria in health administrative data at the population-based level
Multimorbidity prevalence and health outcome prediction: assessing the impact of lookback periods, disease count, and definition criteria in health administrative data at the population-based level Open
Background Health administrative databases play a crucial role in population-level multimorbidity surveillance. Determining the appropriate retrospective or lookback period (LP) for observing prevalent and newly diagnosed diseases in admin…
View article: 10-Year Multimorbidity Trajectories in Older People Have Limited Benefit in Predicting Short-Term Health Outcomes in Comparison to Standard Multimorbidity Thresholds: A Population-Based Study
10-Year Multimorbidity Trajectories in Older People Have Limited Benefit in Predicting Short-Term Health Outcomes in Comparison to Standard Multimorbidity Thresholds: A Population-Based Study Open
Multimorbidity trajectories displayed comparable health outcome predictive capacity to those of traditional cross-sectional multimorbidity indicators. Given its ease of calculation, continued use of traditional multimorbidity thresholds re…
View article: Sex-specific medication trajectories in older adults newly diagnosed with diabetes
Sex-specific medication trajectories in older adults newly diagnosed with diabetes Open
Most males and females with incident diabetes had a high burden of medication following the year of diagnosis and were classified in a group of sustained medication use over time. The largest increase in medication was among those who had …
View article: Impact of chronic comorbidities on hospitalization, intensive care unit admission and death among adult vaccinated and unvaccinated COVID-19 confirmed cases during the Omicron wave
Impact of chronic comorbidities on hospitalization, intensive care unit admission and death among adult vaccinated and unvaccinated COVID-19 confirmed cases during the Omicron wave Open
Background Comorbidities are important risk factors of severe COVID-19 complications. Their impact during the Omicron wave among vaccinated and unvaccinated COVID-19 cases is not well documented. Purpose The objective of this study was to …
View article: Chronic diseases and compliance with provincial guidelines for outpatient antibiotic prescription in cases of otitis media and respiratory infections: a population-based study of linked data in Quebec, Canada, 2010–2017
Chronic diseases and compliance with provincial guidelines for outpatient antibiotic prescription in cases of otitis media and respiratory infections: a population-based study of linked data in Quebec, Canada, 2010–2017 Open
It is possible that prescribing noncompliant prescriptions was sometimes appropriate, but the high frequency of noncompliance suggests room for improvement. Given that variations associated with chronic diseases were small, disease-specifi…
View article: Chronic diseases and variations in rates of antimicrobial use in the community: a population-based analysis of linked administrative data in Quebec, Canada, 2002–2017
Chronic diseases and variations in rates of antimicrobial use in the community: a population-based analysis of linked administrative data in Quebec, Canada, 2002–2017 Open
During the study period, large proportions of antimicrobial prescriptions were for people with chronic diseases, across the age spectrum. Interventions to reduce antimicrobial use should be tailored for these populations.
View article: Major areas of interest of artificial intelligence research applied to health care administrative data: a scoping review
Major areas of interest of artificial intelligence research applied to health care administrative data: a scoping review Open
Introduction: The ongoing collection of large medical data has created conditions for application of artificial intelligence (AI) in research. This scoping review aimed to identify major areas of interest of AI applied to health care admin…
View article: Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic
Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic Open
Background As we are confronted with more transmissible/severe variants with immune escape and the waning of vaccine efficacy, it is particularly relevant to understand how the social contacts of individuals at greater risk of COVID-19 com…
View article: Comparison of Socioeconomic Disparities in Pump Uptake Among Children With Type 1 Diabetes in 2 Canadian Provinces With Different Payment Models
Comparison of Socioeconomic Disparities in Pump Uptake Among Children With Type 1 Diabetes in 2 Canadian Provinces With Different Payment Models Open
The results of this study suggest that the program of full coverage for pumps available in Québec partially mitigates observed SES disparities in uptake and may be a model to improve access for all children with T1D.
View article: Exploring the associations between polypharmacy and COVID-19-related hospitalisations and deaths: a population-based cohort study among older adults in Quebec, Canada
Exploring the associations between polypharmacy and COVID-19-related hospitalisations and deaths: a population-based cohort study among older adults in Quebec, Canada Open
Objectives To study the association between polypharmacy and the risk of hospitalisation and death in cases of COVID-19 in the population over the age of 65. Design Population-based cohort study. Setting Quebec Integrated Chronic Disease S…
View article: Polypharmacy among older individuals with heart failure: trends between 2000 and 2017 in the province of Quebec, Canada
Polypharmacy among older individuals with heart failure: trends between 2000 and 2017 in the province of Quebec, Canada Open
Objective: Pharmacological management of heart failure and comorbidities may result in polypharmacy, but there are few population-based studies that portray the use of medications over time. We aimed to describe the trends in polypharmacy …
View article: Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic
Time trends in social contacts of individuals according to comorbidity and vaccination status, before and during the COVID-19 pandemic Open
Background As we are confronted with more transmissible/severe variants with immune escape and the waning of vaccine efficacy, it is particularly relevant to understand how the social contacts of individuals at greater risk of COVID-19 com…
View article: Trends in benzodiazepine and alternative hypnotic use in relation with multimorbidity among older adults in <scp>Quebec, Canada</scp>
Trends in benzodiazepine and alternative hypnotic use in relation with multimorbidity among older adults in <span>Quebec, Canada</span> Open
Background Benzodiazepines and other hypnotic alternatives are associated with increased risks of adverse events. Heightened awareness of risks may have changed prescribing habits over the years. However, these trends are not fully describ…
View article: 99. Presence of Chronic Diseases and Compliance with Québec Provincial Guidelines for Outpatient Antibiotic Prescription, Québec, Canada, 2010-2017
99. Presence of Chronic Diseases and Compliance with Québec Provincial Guidelines for Outpatient Antibiotic Prescription, Québec, Canada, 2010-2017 Open
Background In Québec primary care, antimicrobial use is higher in patients with chronic diseases, but it is unclear whether this utilization may be reduced. We aimed to measure the proportion of compliant antimicrobial prescriptions accord…
View article: 140. Variations in Rates of Antimicrobial Use in Primary Care, in Relation to the Presence of Chronic Diseases, Québec, Canada, 2014-2017
140. Variations in Rates of Antimicrobial Use in Primary Care, in Relation to the Presence of Chronic Diseases, Québec, Canada, 2014-2017 Open
Background Chronic diseases may increase one’s risk of infection and ensuing complications, which in turn may lower clinicians’ tolerance threshold for antimicrobial prescription, while potential drug interactions may limit therapeutic opt…
View article: Exploring polypharmacy with artificial intelligence: data analysis protocol
Exploring polypharmacy with artificial intelligence: data analysis protocol Open
Background Polypharmacy is common among older adults and it represents a public health concern, due to the negative health impacts potentially associated with the use of several medications. However, the large number of medication combinat…
View article: One‐year persistence of potentially inappropriate medication use in older adults: A population‐based study
One‐year persistence of potentially inappropriate medication use in older adults: A population‐based study Open
Aims To assess the 1‐year persistence of potentially inappropriate medication (PIM) use and identify associated factors in community‐dwelling older adults in Quebec, Canada. Methods A population‐based cohort study was conducted using the Q…
View article: Risk of Psychiatric Disorders and Suicide Attempts in Emerging Adults With Diabetes
Risk of Psychiatric Disorders and Suicide Attempts in Emerging Adults With Diabetes Open
OBJECTIVE To determine the longitudinal risks of psychiatric disorders in adolescents and emerging adults with versus without diabetes. RESEARCH DESIGN AND METHODS We conducted a retrospective cohort study in Quebec, Canada, using linked h…