Chen‐Yu Zhang
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View article: Opportunistic AI-derived adiposity measures from coronary artery calcium scans predict new-onset type 2 diabetes in adults without obesity or hyperglycemia: insights from the AI-CVD study within MESA
Opportunistic AI-derived adiposity measures from coronary artery calcium scans predict new-onset type 2 diabetes in adults without obesity or hyperglycemia: insights from the AI-CVD study within MESA Open
AI-derived adiposity measures from CAC scans-especially liver fat-can identify adults without obesity or hyperglycemia at elevated risk for developing T2DM. These findings underscore the potential of AI-enabled opportunistic screening duri…
View article: Multi‐fidelity data meta‐learning approach for seismic response prediction of high‐rise shear wall buildings
Multi‐fidelity data meta‐learning approach for seismic response prediction of high‐rise shear wall buildings Open
Rapid and accurate estimation of seismic responses in city‐scale buildings is critical for post‐earthquake loss assessment and pre‐event identification of vulnerable buildings. However, conventional numerical simulation methods struggle to…
View article: Association of appendectomy with disease phenotype and clinical course in Crohn's disease: results from two cohorts
Association of appendectomy with disease phenotype and clinical course in Crohn's disease: results from two cohorts Open
View article: Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy
Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy Open
Maintaining skeletal muscle mass is crucial for health, as muscle atrophy caused by drugs, cancer, or aging poses serious risks. However, there are few effective pharmacological interventions targeting muscle atrophy, highlighting the need…
View article: Inhibition of Ephrin receptor signaling in the paraventricular nucleus attenuates psoriasis-like dermatitis via synaptic plasticity and immune homeostasis modulation
Inhibition of Ephrin receptor signaling in the paraventricular nucleus attenuates psoriasis-like dermatitis via synaptic plasticity and immune homeostasis modulation Open
Psoriasis pathophysiology involves dysregulated neuroimmune crosstalk, yet the central mechanisms involved remain incompletely understood. Here, we show that the hypothalamic paraventricular nucleus (PVN) orchestrates cutaneous inflammatio…
View article: Analysis of the Manifestations and Causes of Gender Differences in Personality Traits
Analysis of the Manifestations and Causes of Gender Differences in Personality Traits Open
At present, the exploration of personality traits in the field of psychology is becoming increasingly in-depth. This article explores the relationship between gender and personality traits in light of the differences between men and women …
View article: Commentary on “Acute pain service for postoperative pain in adults: a network meta-analysis”
Commentary on “Acute pain service for postoperative pain in adults: a network meta-analysis” Open
View article: Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis
Distinct Virologic Properties of African and Epidemic Zika Virus Strains: The Role of the Envelope Protein in Viral Entry, Immune Activation, and Neuropathogenesis Open
The 2016 Zika virus (ZIKV) epidemic has largely subsided, but a key question remains. How did ZIKV evolve to become a virulent human pathogen compared to the virus of its original discovery? What specific virologic and pathologic changes c…
View article: Unraveling the prognostic puzzle: an in-depth exploration of lymph node metrics in surgically treated FIGO stage IB-IIA cervical cancer – A retrospective cohort study focused on the number of positive lymph nodes and the lymph node ratio
Unraveling the prognostic puzzle: an in-depth exploration of lymph node metrics in surgically treated FIGO stage IB-IIA cervical cancer – A retrospective cohort study focused on the number of positive lymph nodes and the lymph node ratio Open
Background: Lymph node (LN) metastasis constitutes a major adverse prognostic factor in surgically treated cervical cancer (CC) patients. Leveraging the Surveillance, Epidemiology, and End Results database, this study aimed to evaluate the…
View article: TEA5K: a high-resolution and liquid-phase multiple-SNP array for molecular breeding in tea plant
TEA5K: a high-resolution and liquid-phase multiple-SNP array for molecular breeding in tea plant Open
The TEA5K mSNP array is presented as a flexible, cost-effective, and low-maintenance genotyping tool that significantly enhances both genetic research and molecular breeding in tea plants. By providing a robust platform for genome-wide ana…
View article: The Evolving Role of Zika Virus Envelope Protein in Viral Entry and Pathogenesis
The Evolving Role of Zika Virus Envelope Protein in Viral Entry and Pathogenesis Open
Zika virus (ZIKV) was first discovered in Uganda’s Zika Forest in 1947. The early African viruses posed little or no health risk to humans. Since then, ZIKV has undergone extensive genetic evolution and adapted to humans, and it now causes…
View article: QTL detection and candidate gene analysis of the anthracnose resistance locus in tea plant (Camellia sinensis)
QTL detection and candidate gene analysis of the anthracnose resistance locus in tea plant (Camellia sinensis) Open
View article: Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function
Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function Open
The gut and lung microbiota are associated with asthma. Osteopontin (OPN) is an important cytokine associated with several inflammatory diseases. The potential role of OPN in the asthma-associated microbiome remains poorly understood. Here…
View article: Prediction models of breast cancer molecular subtypes based on multimodal ultrasound and clinical features
Prediction models of breast cancer molecular subtypes based on multimodal ultrasound and clinical features Open
In conclusion, multimodal ultrasound features had differences between molecular subtypes of breast cancer and models based on multimodal ultrasound data facilitated the prediction of molecular subtypes.
View article: Stacking-orientation and twist-angle control on integer and fractional Chern insulators in moiré rhombohedral graphene
Stacking-orientation and twist-angle control on integer and fractional Chern insulators in moiré rhombohedral graphene Open
Rhombohedral-stacked multilayer graphene aligned with hexagonal boron nitride has emerged as an excellent platform for investigating exotic quantum phenomena arising from the interplay between electron correlations and nontrivial topology.…
View article: Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage
Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage Open
Accumulating evidence has identified disrupted oxytocin signaling in both autistic patients and animal models of autism. Nevertheless, the specific timing of the impact of oxytocin on social behavior has remained unclear. Using mouse strai…
View article: Unraveling new therapeutic targets in ankylosing spondylitis: Multi-omics Mendelian randomization on immune cells, metabolites, and inflammation proteins
Unraveling new therapeutic targets in ankylosing spondylitis: Multi-omics Mendelian randomization on immune cells, metabolites, and inflammation proteins Open
This study aims to identify novel immunological, metabolic, and inflammatory determinants of ankylosing spondylitis (AS) using Mendelian randomization (MR), offering new insights into its pathogenesis and potential therapeutic intervention…
View article: Impaired response inhibition to negative emotional stimuli in depressed adolescents with non-suicidal self-injury: a neurophysiological perspective
Impaired response inhibition to negative emotional stimuli in depressed adolescents with non-suicidal self-injury: a neurophysiological perspective Open
Background Non-suicidal self-injury (NSSI) is an increasingly recognized clinical and public health issue among adolescents. This behavior exhibits certain addictive characteristics, leading it to be classified as a behavioral addiction. R…
View article: Dexmedetomidine improves prognosis in septic patients with myocardial injury and lower APACHE IV scores: a retrospective cohort study
Dexmedetomidine improves prognosis in septic patients with myocardial injury and lower APACHE IV scores: a retrospective cohort study Open
View article: Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction
Ionizing radiation-induced disruption of Rela-Bclaf1-spliceosome regulatory axis in primary spermatocytes causing spermatogenesis dysfunction Open
View article: The Epidemiology, Spa Types, and Antibiotic Sensitivity Profile of Staphylococcus Aureus Isolated from Pigeons in Xinjiang, China
The Epidemiology, Spa Types, and Antibiotic Sensitivity Profile of Staphylococcus Aureus Isolated from Pigeons in Xinjiang, China Open
View article: Roles of RNAkines in regulating glucose homeostasis
Roles of RNAkines in regulating glucose homeostasis Open
View article: Blockade of TREM-1 alleviates alveolar epithelial cell senescence through Nrf2-mediated antioxidant pathways in pulmonary fibrosis
Blockade of TREM-1 alleviates alveolar epithelial cell senescence through Nrf2-mediated antioxidant pathways in pulmonary fibrosis Open
Our previous study showed that blocking triggering receptors expressed on myeloid cell-1 (TREM-1) attenuate bleomycin (BLM)-induced pulmonary fibrosis (PF) in mice. However, its underlying mechanism remains unclear. Here, we found that blo…
View article: Observation of non-Hermitian boundary induced hybrid skin-topological effect excited by synthetic complex frequencies
Observation of non-Hermitian boundary induced hybrid skin-topological effect excited by synthetic complex frequencies Open
The hybrid skin-topological effect (HSTE) has recently been proposed as a mechanism where topological edge states collapse into corner states under the influence of the non-Hermitian skin effect (NHSE). However, directly observing this eff…
View article: Multifaceted roles of mitochondria in asthma
Multifaceted roles of mitochondria in asthma Open
View article: vSPACE: exploring virtual spatial representation of articular chondrocytes at the single-cell level
vSPACE: exploring virtual spatial representation of articular chondrocytes at the single-cell level Open
Summary vSPACE is a web-based application presenting a spatial representation of scRNAseq data obtained from human articular cartilage by emulating the concept of spatial transcriptomics technology, but virtually. This virtual 2D plot pres…
View article: SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production
SARS-CoV-2 ORF3a induces COVID-19-associated kidney injury through HMGB1-mediated cytokine production Open
The primary challenge posed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is COVID-19-related mortality, often exacerbated by additional medical complications, such as COVID-19-associated kidney injuries (CAKIs)…
View article: Advanced Protocol for Molecular Characterization of Viral Genome in Fission Yeast (Schizosaccharomyces pombe)
Advanced Protocol for Molecular Characterization of Viral Genome in Fission Yeast (Schizosaccharomyces pombe) Open
Fission yeast, a single-cell eukaryotic organism, shares many fundamental cellular processes with higher eukaryotes, including gene transcription and regulation, cell cycle regulation, vesicular transport and membrane trafficking, and cell…
View article: Three-dimensional non-reciprocal transport in photonic topological heterostructure of arbitrary shape
Three-dimensional non-reciprocal transport in photonic topological heterostructure of arbitrary shape Open
Electromagnetic wave propagation in three-dimensional space typically suffers omnidirectional scattering when encountering obstacles. In this study, we employed Chern vectors to construct a topological heterostructure, where large-volume n…
View article: Exploring the Genetic Links Between Asthma, Gastroesophageal Reflux Disease, and Osteoarthritis Through Mendelian Randomization
Exploring the Genetic Links Between Asthma, Gastroesophageal Reflux Disease, and Osteoarthritis Through Mendelian Randomization Open
To elucidate the bidirectional associations and mechanisms linking the increasingly prevalent conditions of asthma, gastroesophageal reflux disease (GERD), and osteoarthritis (OA), with a focus on exploring the mediating role of Nonsteroid…