Explanipedia

Human Albumin infusion in liver Cirrhosis and overt Hepatic Encephalopathy (HACHE): protocol of an investigator-initiated, open-label, multicentre, randomised controlled trial Open

Qianqian Li, Huan Tong, Xuemei Liu, Fei Liao, Han Ma , et al. · 2025

Introduction Hepatic encephalopathy (HE), a severe complication of decompensated cirrhosis, is characterised as neurocognitive dysfunction. Emerging evidence suggests the potential role of human albumin infusion for the treatment of HE, bu…

MASLD development: From molecular pathogenesis toward therapeutic strategies Open

Zhu Yang, Jiahui Zhao, Kexin Xie, Chengwei Tang, Can Gan , et al. · 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) comprises a spectrum of liver injuries, including steatosis to steatohepatitis (MASH), liver fibrosis, cirrhosis, and relevant complications. The liver mainly comprises hepat…

Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial Open

Li Huang, Zhe Feng, Wenjuan Yang, Yin Zhu, Jing Li , et al. · 2025

Background There is no effective drug treatment for the organ failure (OF) caused by severe acute pancreatitis (SAP). Objective We aimed to evaluate the efficacy of cyclooxygenase-2 inhibitors (COX-2-Is) on the treatment of SAP and its saf…

Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury Open

Yang Zhu, Tai Yang, Lü Tian, Chong Zhao, Jinhang Gao , et al. · 2025

Ferroptosis contributes to the progression of chronic liver injury. Inhibition of COX-2 upregulates Nrf2, mitigating hepatocyte ferroptosis in chronic liver injury.

Activatable fluorescent probes for atherosclerosis theranostics Open

Yuanyuan You, Chengwei Tang, Songling Lin, Wenman Li, Yuchao Li , et al. · 2024

The onset of atherosclerosis (AS) is insidious, and early stage patients have atypical clinical symptoms. After being diagnosed in late stage, it is often prone to sudden and fatal cardiovascular events. Therefore, it is highly desirable t…

Effect of different diameter stents on clinical outcomes of TIPS for variceal rebleeding: A multicenter clinical study Open

Yifu Xia, Jun Tie, Ruiyin Ge, Guangchuan Wang, Yuzheng Zhuge , et al. · 2024

Background Performing transjugular intrahepatic portosystemic shunt with different diameter stents leads to different portal pressure gradients and clinical outcomes. However, which diameter is more beneficial is unclear. This study aimed …

Recent developments in the management of ascites in cirrhosis Open

Tian Lan, Ming Chen, Chengwei Tang, Pierre Deltenre · 2024

In recent years, advances have been made for treating ascites in patients with cirrhosis. Recent studies have indicated that several treatments that have been used for a long time in the management of portal hypertension may have beneficia…

ALOX5 acts as a key role in regulating the immune microenvironment in intrahepatic cholangiocarcinoma, recruiting tumor-associated macrophages through PI3K pathway Open

Jialu Chen, Yue Tang, Delong Qin, Xiaopeng Yu, Huanjun Tong , et al. · 2023

Disruption of cholangiocyte-B cell crosstalk by blocking the CXCL12-CXCR4 axis alleviates liver fibrosis Open

Linhao Zhang, Chong Zhao, Wenting Dai, Huan Tong, Wenjuan Yang , et al. · 2023

Guidelines for the Management of Esophagogastric Variceal Bleeding in Cirrhotic Portal Hypertension Open

Xiaoyuan Xu, Chengwei Tang, Enqiang Linghu, Huiguo Ding · 2023

To standardize the diagnosis, treatment, and management of esophagogastric variceal bleeding (EVB) in patients with cirrhotic portal hypertension, the Chinese Society of Hepatology, the Chinese Society of Gastroenterology, and the Chinese …

Incidence, prevalence, and comorbidities of chronic pancreatitis: A 7-year population-based study Open

Qiu-Yu Cai, Kun Tan, Xueli Zhang, Xu Han, Jingping Pan , et al. · 2023

Many studies point to an association between Helicobacter pylori (H. pylori ) infection and inflammatory bowel diseases (IBD). Although controversial, this association indicates that the presence of the bacterium somehow affects the course…

Issue Information Open

Vineet Ahuja, Yock Young, Lawrence Khek, Yu Ho, Sanjiv Mahadeva , et al. · 2023

Featured Cover Open

Chong Zhao, Shuaijie Qian, Yang Tai, Yangkun Guo, Chengwei Tang , et al. · 2023

The cover image is based on the Original Article Proangiogenic role of circRNA‐007371 in liver fibrosis by Chong Zhao et al., https://doi.org/10.1111/cpr.13432 . image

Issue Information Open

Vineet Ahuja, Yock Young, Ajay Duseja, Lawrence Khek, Yu Ho , et al. · 2023

STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome Open

Yang Xiao, Chong Zhao, Yang Tai, Bei Li, Tian Lan , et al. · 2023

Issue Information Open

Vineet Ahuja, Yock Young, Ajay Duseja, Lawrence Khek, Yu Ho , et al. · 2023

Proangiogenic role of <span>circRNA</span>‐007371 in liver fibrosis Open

Chong Zhao, Shuaijie Qian, Yang Tai, Yangkun Guo, Chengwei Tang , et al. · 2023

Circular RNAs (circRNAs) are crucially involved in cancers as competing endogenous RNA (ceRNA) or microRNA (miRNA) sponges. However, the function and mechanism of circRNAs in liver fibrosis remain unknown and are the focus of this study. M…

Individualized portal pressure gradient threshold based on liver function categories in preventing rebleeding after TIPS Open

Yifu Xia, Jun Tie, Guangchuan Wang, Yuzheng Zhuge, Hao Wu , et al. · 2023

Background The evidence in Portal pressure gradient (PPG) < 12 mmHg after transjugular intrahepatic portosystemic shunt (TIPS) for preventing rebleeding mostly comes from observations in uncovered stents era. Moreover, association between …

C-C motif chemokine receptor 2 inhibition reduces liver fibrosis by restoring the immune cell landscape Open

Yangkun Guo, Chong Zhao, Wenting Dai, Bowen Wang, Enjiang Lai , et al. · 2023

The accumulation of extracellular matrix (ECM) proteins in the liver leads to liver fibrosis and end-stage liver cirrhosis. C-C motif chemokine receptor 2 (CCR2) is an attractive target for treating liver fibrosis. However, limited investi…

Chronic Liver Disease or Cirrhotic Patients Infected with SARS-CoV-2 Benefited from the Usual Oral Selective COX-2 Inhibitor Open

Ming Chen, Zhu Yang, Hui Gong, Hu Wu, Ling Liu , et al. · 2023

Issue Information Open

Vineet Ahuja, Yock Young, Ajay Duseja, Lawrence Khek, Yu Ho , et al. · 2023

Establishment and experimental validation of a novel cuproptosis-related gene signature for prognostic implication in cholangiocarcinoma Open

Jialu Chen, Xiaopeng Yu, Huanjun Tong, Chengwei Tang, Zhaohui Tang · 2022

Background Cholangiocarcinoma (CCA) is a highly malignant, heterogeneous bile duct malignancy with poor treatment options. A novel type of cell death termed cuproptosis was recently demonstrated to closely correlate with tumor progression.…

Issue Information Open

Khean-Lee Goh, Vineet Ahuja, Ajay Duseja, Lawrence Khek, Yu Ho , et al. · 2022

Individualized Portal Pressure Gradient Threshold Based on Liver Function Categories in Preventing Rebleeding After TIPS Open

Yifu Xia, Jun Tie, Guangchuan Wang, Yuzheng Zhuge, Hao Wu , et al. · 2022

Background: The evidence in Portal pressure gradient (PPG) < 12 mmHg after transjugular intrahepatic portosystemic shunt (TIPS) for preventing rebleeding mostly comes from observations in uncovered stents era. Moreover, association between…

Fecal fungal microbiota alterations associated with clinical phenotypes in Crohn’s disease in southwest China Open

Li Zeng, Zhe Feng, Zhuo Ma, Zhonghui Wen, Cairong Zhu , et al. · 2022

Although previous studies reported that gut fungal microbiota was associated with Crohn’s disease (CD), only a few studies have focused on the correlation between gut fungi and clinical phenotypes of CD. Here, we aimed to analyze the assoc…

Correction: Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats Open

Jinhang Gao, Shilei Wen, Feng Shi, Wenjuan Yang, Yaoyao Lu , et al. · 2022

Inflammasomes and Pyroptosis of Liver Cells in Liver Fibrosis Open

Can Gan, Qiuyu Cai, Chengwei Tang, Jinhang Gao · 2022

Inflammasomes are multiprotein complexes that can sense danger signals and activate caspase-1 to mediate pro-inflammatory cytokines release and pyroptotic cell death. There are two main canonical and non-canonical signaling pathways that t…

Role of Immune Cells in Biliary Repair Open

Tian Lan, Shuaijie Qian, Chengwei Tang, Jinhang Gao · 2022

The biliary system is comprised of cholangiocytes and plays an important role in maintaining liver function. Under normal conditions, cholangiocytes remain in the stationary phase and maintain a very low turnover rate. However, the robust …

Author Correction: Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer Open

Jinhang Gao, Chunhui Wang, Huan Tong, Shilei Wen, Zhiyin Huang , et al. · 2022

Inhibition of Transketolase Improves the Prognosis of Colorectal Cancer Open

Linhao Zhang, Zhiyin Huang, Qiuyu Cai, Chong Zhao, Yang Xiao , et al. · 2022

Colorectal cancer (CRC) remains a heavy health burden worldwide. Transketolase (TKT) is a crucial enzyme in the non-oxidative phase of the Pentose Phosphate Pathway (PPP), and is up-regulated in multiple cancer types. However, the role of …

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