Explanipedia

Bali Chronic Constipation Roundtable Report: Chronic Constipation Management in Asia Open

Wah Loong Chan, Yong Sung Kim, Atsushi Nakajima, Yeong Yeh Lee, Tao Bai , et al. · 2025

The Bali Chronic Constipation Roundtable highlighted Asia's need for region specific diagnostics and management. Addressing diagnostic and treatment gaps will improve outcomes, while ongoing researcher clinician policy collaboration must s…

ePWV as a scalable risk factor for large-scale glaucoma screening: evidence from a national Chinese cohort Open

Kun Liu, Zihan Yin, Qiaoyun Gong, Mingjie Zhu, Ching‐Liang Lu , et al. · 2025

Background To examine the association between estimated pulse wave velocity (ePWV), a marker of arterial stiffness, and glaucoma incidence in Chinese cohort, highlighting ePWV’s potential as a scalable population-level risk factor for glau…

Clinical impact of pharmacogenetic risk variants in a large chinese cohort Open

Chun-Yu Wei, Ming‐Shien Wen, Chih-Kuang Cheng, Yi‐Jing Sheen, Tsung‐Chieh Yao , et al. · 2025

Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcomes by optimizing drug selection and dosage based on genetic factors affecting drug response. A key advantage of PGx-guided therapy is to decrease t…

Dietary sodium butyrate supplementation during mid-to-late gestation enhances reproductive performance and antioxidant capability in sows Open

Ching‐Liang Lu, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu , et al. · 2025

Sodium butyrate (NaB) has been used as a feed additive in livestock production due to its antioxidant and anti-inflammatory properties. However, the effect of dietary NaB supplementation during mid- to late gestation on the reproductive pe…

The optimal labelling method for artificial intelligence-assisted polyp detection in colonoscopy Open

Yen‐Po Wang, Ying-Chun Jheng, Ming‐Chih Hou, Ching‐Liang Lu · 2024

Labelling methodology affect the predictability of AI model in polyp detection. Extending the bounding box to 20% of the polyp margin would result in the best polyp detection predictive model based on AUC data. It is mandatory to establish…

Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open

Pui–Yan Kwok, Ming‐Shien Wen, Chih-Kuang Cheng, Yi‐Jing Sheen, Tsung‐Chieh Yao , et al. · 2024

Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response¹. One of the most pro…

Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort Open

Chunyu Wei, Ming‐Shien Wen, Chih-Kuang Cheng, Yi‐Jing Sheen, Tsung‐Chieh Yao , et al. · 2024

Incorporating pharmacogenetics into clinical practice promises to improve therapeutic outcome by choosing the medication and dosage optimized for a patient based on genetic factors that affect drug response 1 . One of the most promising be…

Early double-balloon enteroscopy was not related to better clinical outcomes in patients with suspected overt small bowel bleeding Open

Yong‐Cheng Ye, Kuang‐Yi Sung, Tien-En Chang, Pei-Shan Wu, Yen‐Po Wang , et al. · 2024

Background: Device-assisted enteroscopy has been used for over 20 years for the management of patients with suspected small bowel bleeding. Unlike esophagogastroduodenoscopy and colonoscopy, the appropriate timing of enteroscopy is still u…

Risk factors for symptom relapse in patients with <span>Los Angeles Grade A/B</span> erosive esophagitis Open

Chih‐An Shih, Seng‐Kee Chuah, Ping‐I Hsu, Ching‐Liang Lu, Sung‐Shuo Kao , et al. · 2023

Recurrence of reflux symptoms following discontinuing proton pump inhibitor therapy is a common problem in the treatment of gastroesophageal reflux disease. We aim (1) to examine the cumulative 12‐week incidence of symptom relapse followin…

Inflammatory Bowel Disease and Neurodegenerative Diseases Open

Jin Sun Kim, Mu‐Hong Chen, Hohui E. Wang, Ching‐Liang Lu, Yen‐Po Wang , et al. · 2023

A growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci of comorbidities between IBD and mood disorders. These new disco…

Differences in gut microbiota correlate with symptoms and regional brain volumes in patients with late-life depression Open

Chia-Fen Tsai, Chia-Hsien Chuang, Yen‐Po Wang, Ya-Bo Lin, Pei‐Chi Tu , et al. · 2022

Depression is associated with gut dysbiosis that disrupts a gut-brain bidirectional axis. Gray matter volume changes in cortical and subcortical structures, including prefrontal regions and the hippocampus, have also been noted in depressi…

Use of U-Net Convolutional Neural Networks for Automated Segmentation of Fecal Material for Objective Evaluation of Bowel Preparation Quality in Colonoscopy Open

Yen‐Po Wang, Ying-Chun Jheng, Kuang‐Yi Sung, Hung-En Lin, I‐Fang Hsin , et al. · 2022

Background: Adequate bowel cleansing is important for colonoscopy performance evaluation. Current bowel cleansing evaluation scales are subjective, with a wide variation in consistency among physicians and low reported rates of accuracy. W…

Use of U-Net Convolutional Neural Networks for Automated Segmentation of Fecal Material to Objective Evaluation of Bowel Preparation Quality in Colonoscopy (Preprint) Open

Yen‐Po Wang, Ying-Chun Jheng, Kuang‐Yi Sung, Hung-En Lin, I‐Fang Hsin , et al. · 2021

BACKGROUND Adequate bowel cleansing is important for a complete examination of the colon mucosa during colonoscopy. Current bowel cleansing evaluation scales are subjective with a wide variation in consistency among physicians and low rep…

Association between gastrointestinal symptoms and depression among older adults in Taiwan: A cross-sectional study Open

Mao‐Hsuan Huang, Yen‐Po Wang, Po-Shan Wu, Yee-Lam E. Chan, Chih‐Ming Cheng , et al. · 2020

Background: Older adults with depression more frequently experience somatic and gastrointestinal (GI) problems compared with people without depression and younger adults with depression. However, whether GI symptoms are predictive of eleva…

Knowledge, Attitude, and Practice Survey of Gastroparesis in Asia by Asian Neurogastroenterology and Motility Association Open

Tadayuki Oshima, Kewin Tien Ho Siah, Yong Sung Kim, Tanisa Patcharatrakul, Chien‐Lin Chen , et al. · 2020

Gastroparesis can be challenging to diagnose due to the lack of instrument, standardized method, and paucity of research data on normative value, risk factors, and treatment studies in Asian patients. Future strategies should concentrate o…

Targeting the gut microbiota for the treatment of irritable bowel syndrome Open

Charles Herndon, Yen‐Po Wang, Ching‐Liang Lu · 2019

Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder that affects an estimated 11% of people across the world. IBS patients are one of the largest subgroups seen in gastroenterology clinics, exhibit a lesser quality of lif…

Non-pharmacological Approach in the Management of Functional Dyspepsia Open

Yen‐Po Wang, Charles Herndon, Ching‐Liang Lu · 2019

Functional dyspepsia (FD) is a common functional gastrointestinal disease which bears a significant burden on society and individuals. Despite the high prevalence of FD, its pathophysiology remains poorly understood and the treatment optio…

Second Asian Consensus on Irritable Bowel Syndrome Open

Kok‐Ann Gwee, Sutep Gonlachanvit, Uday C. Ghoshal, Andrew Seng Boon Chua, Hiroto Miwa , et al. · 2019

Our consensus is that all patients with functional gastrointestinal disorders should be evaluated comprehensively with a view to holistic management. Physicians should be encouraged to take a positive attitude to the treatment outcomes for…

Altered cognitive control network is related to psychometric and biochemical profiles in covert hepatic encephalopathy Open

Chia-Fen Tsai, Pei-Chi Tu, Yen‐Po Wang, Chi‐Jen Chu, Yi‐Hsiang Huang , et al. · 2019

Combination of structural and vascular optical coherence tomography for differentiating oral lesions of mice in different carcinogenesis stages Open

Ping-Hisen Chen, Chien‐Hsien Wu, Yi-Fen Chen, Yi‐Chen Yeh, Bo-Han Lin , et al. · 2018

Differentiating between early malignancy and benign lesions in oral cavities is difficult using current optical tools. As has been shown in previous studies, microvascular changes in squamous epithelium can be regarded as a key marker for …

Sexual Abuse Is Associated With an Abnormal Psychological Profile and Sleep Difficulty in Patients With Irritable Bowel Syndrome in Taiwan Open

Hsing‐Feng Lee, Pei-Yi Liu, Yen‐Po Wang, Chia-Fen Tsai, Full-Young Chang , et al. · 2018

In Taiwan, sexual abuse history was more prevalent in female IBS patients than controls. Sexual abuse history may contribute to higher anxiety/depression levels and sleep difficulties, which are commonly experienced in IBS patients. In Asi…

Reply Open

Fu‐Ming Chang, Yen‐Po Wang, Ching‐Liang Lu · 2017

Potential conflict of interest: Nothing to report. Author names in bold designate shared co‐first authorship. Reply: We really appreciate the opinions from Dr. Lin regarding methodological issues of our recent published article.1 Indeed, o…

Statins decrease the risk of decompensation in hepatitis B virus– and hepatitis C virus–related cirrhosis: A population‐based study Open

Fu‐Ming Chang, Yen‐Po Wang, Hui‐Chu Lang, Chia‐Fen Tsai, Ming‐Chih Hou , et al. · 2017

Statin use decreases the risk of decompensation and mortality in patients with cirrhosis due to hepatitis C virus (HCV). Whether this beneficial effect can be extended to cirrhosis in the general population or cirrhosis due to other causes…

Establishing a risk scoring system for predicting erosive esophagitis Open

Hung‐Hsu Hung, Chien‐Wei Su, Yuan‐Jen Wang, Jiing‐Chyuan Luo, Hsin‐Bang Leu , et al. · 2015

Summary Objective This study aims to establish a noninvasive scoring system to predict the risk of erosive esophagitis (EE). Methods From 2002 to 2009, a total of 34,346 consecutive adults who underwent health check‐ups and upper gastroint…

Erratum: Development, Translation and Validation of Enhanced Asian Rome III Questionnaires for Diagnosis of Functional Bowel Diseases in Major Asian Languages: A Rome Foundation-Asian Neurogastroenterology and Motility Association Working Team Report Open

Uday C. Ghoshal, Kok‐Ann Gwee, Minhu Chen, Xiao Rong Gong, Nitesh Pratap , et al. · 2015

Uday C Ghoshal, Kok-Ann Gwee, Minhu Chen, Xiao R Gong, Nitesh Pratap, Xiaohua Hou, Ari F Syam, Murdani Abdullah, Young-Tae Bak, Myung-Gyu Choi, Sutep Gonlachanvit, Andrew S B Chua, Kuck-Meng Chong, Kewin T H Siah, Ching-Liang Lu, Lishou Xi…

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