Chao-Yang Lai
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View article: Potential impact of omentin-1 genetic variants on perineural invasion in prostate cancer
Potential impact of omentin-1 genetic variants on perineural invasion in prostate cancer Open
One of the most prevalent cancers and a major global cause of mortality in men is prostate cancer (PCa). Omentin-1, an adipokine, has been shown to play a protective role by reducing proinflammatory cytokine secretion. The relationships am…
View article: Apelin facilitates integrin αvβ3 production and enhances metastasis in prostate cancer by activating STAT3 and inhibiting miR-8070
Apelin facilitates integrin αvβ3 production and enhances metastasis in prostate cancer by activating STAT3 and inhibiting miR-8070 Open
Prostate cancer is the most common cancer in men and is often associated with distant metastasis in its later stages. Cell surface receptors called integrins function as adhesion molecules that mediate both cell adhesion and motility. The …
View article: Tumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1α activation
Tumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1α activation Open
Background Cancer is characterized by dysregulated cellular metabolism. Thus, understanding the mechanisms underlying these metabolic alterations is important for developing targeted therapies. In this study, we investigated the pro-tumora…
View article: Supplementary Methods, Table 1, Figures 1-5 from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma
Supplementary Methods, Table 1, Figures 1-5 from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma Open
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View article: Data from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma
Data from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma Open
We established an inducible KrasG12D-driven lung adenocarcinoma in CCSP-rtTA/TetO-Cre/LSL-KrasG12D mice that enable pursuits of the cellular and molecular processes involved in Kras-induced tumori…
View article: Supplementary Methods, Table 1, Figures 1-5 from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma
Supplementary Methods, Table 1, Figures 1-5 from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma Open
PDF file - 5.3MB
View article: Data from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma
Data from Identification of Tumorigenic Cells in <i>Kras<sup>G12D</sup></i>-Induced Lung Adenocarcinoma Open
We established an inducible KrasG12D-driven lung adenocarcinoma in CCSP-rtTA/TetO-Cre/LSL-KrasG12D mice that enable pursuits of the cellular and molecular processes involved in Kras-induced tumori…
View article: Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration
Melatonin Inhibits VEGF-Induced Endothelial Progenitor Cell Angiogenesis in Neovascular Age-Related Macular Degeneration Open
Neovascular age-related macular degeneration (AMD) is described as abnormal angiogenesis in the retina and the leaking of fluid and blood that generates a huge, dark, blind spot in the center of the visual field, causing severe vision loss…
View article: Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization
Omentin-1 ameliorates the progress of osteoarthritis by promoting IL-4-dependent anti-inflammatory responses and M2 macrophage polarization Open
Osteoarthritis (OA) is a prevalent joint disease commonly associated with aging and obesity, which can lead to pain, stiffness, joint dysfunction, and disability. Omentin-1 (also called intelectin-1) is a newly discovered adipokine, which …
View article: Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma
Glutamine metabolism controls amphiregulin-facilitated chemoresistance to cisplatin in human chondrosarcoma Open
Chondrosarcoma is the second most common type of bone cancer. At present, the most effective clinical course of action is surgical resection. Cisplatin is the chemotherapeutic medication most widely used for the treatment of chondrosarcoma…
View article: Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis
Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis Open
Osteosarcoma is a highly mortal bone tumor, with a high metastatic potential, promoted in part by the enzyme procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 (PLOD2). Increasing level of PLOD2 in osteosarcoma tissue correlates with lympha…
View article: IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis
IL-17 Facilitates VCAM-1 Production and Monocyte Adhesion in Osteoarthritis Synovial Fibroblasts by Suppressing miR-5701 Synthesis Open
Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocytes into the inflamed joint synovium. Interleukin (IL)-17 is a critical inflammatory mediator that participates in the progression of OA, although the mechanism…
View article: Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice
Single-cell RNA sequencing uncovers the individual alteration of intestinal mucosal immunocytes in Dusp6 knockout mice Open
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Table of Contents Open
View article: Type I Interferon Signaling Accelerates Liver Regeneration by Metabolic Modulation in Noninfectious Conditions
Type I Interferon Signaling Accelerates Liver Regeneration by Metabolic Modulation in Noninfectious Conditions Open
Type I interferon (IFN-I) has a well-known function in controlling viral infections, but its contribution in hepatocyte proliferation and hepatocellular carcinoma (HCC) formation remains unclear. Mice deficient in IFN-α receptor expression…
View article: Correction: USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation
Correction: USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation Open
A correction to this paper has been published and can be accessed via a link at the top of the paper.
View article: Immunostimulatory Activities of CpG-Oligodeoxynucleotides in Teleosts: Toll-Like Receptors 9 and 21
Immunostimulatory Activities of CpG-Oligodeoxynucleotides in Teleosts: Toll-Like Receptors 9 and 21 Open
Toll-like receptors (TLRs) are pattern-recognition receptors that detect a wide variety of microbial pathogens for the initiation of host defense immunological responses. Thirteen TLRs have been identified in mammals, and teleosts contain …
View article: Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation
Involvement of M1 Macrophage Polarization in Endosomal Toll-Like Receptors Activated Psoriatic Inflammation Open
Psoriasis is a chronic inflammatory skin disorder that affects ~2%–3% of the worldwide population. Inappropriate and excessive activation of endosomal Toll-like receptors 7, 8, and 9 (TLRs 7–9) at the psoriatic site has been shown to play …
View article: Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes
Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes Open
Accelerated blood clearance (ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells (KCs) and ABC phenomenon has been studied b…
View article: USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation
USP17 mediates macrophage-promoted inflammation and stemness in lung cancer cells by regulating TRAF2/TRAF3 complex formation Open
A correction to this paper has been published and can be accessed via a link at the top of the paper.
View article: Establishment of a mouse model for the complete mosquito-mediated transmission cycle of Zika virus
Establishment of a mouse model for the complete mosquito-mediated transmission cycle of Zika virus Open
Zika virus (ZIKV) is primarily transmitted by Aedes mosquitoes in the subgenus Stegomyia but can also be transmitted sexually and vertically in humans. STAT1 is an important downstream factor that mediates type I and II interferon signalin…
View article: Neutrophil-mediated delivery of pixantrone-loaded liposomes decorated with poly(sialic acid)–octadecylamine conjugate for lung cancer treatment
Neutrophil-mediated delivery of pixantrone-loaded liposomes decorated with poly(sialic acid)–octadecylamine conjugate for lung cancer treatment Open
Poly(sialic acid) (PSA) is a natural hydrophilic biodegradable and non-immunogenic biopolymer, receptors for its monomer are expressed on peripheral blood neutrophils (PBNs), which plays important roles in the progression and invasion of t…
View article: Macrophages promote progression of lung cancer by regulating ubiquitin-specific peptidase 17 in cancer cells
Macrophages promote progression of lung cancer by regulating ubiquitin-specific peptidase 17 in cancer cells Open
View article: Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation
Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation Open
Psoriasis is a chronic inflammatory autoimmune disease that can be initiated by excessive activation of endosomal toll-like receptors (TLRs), particularly TLR7, TLR8, and TLR9. Therefore, inhibitors of endosomal TLR activation are being in…
View article: WITHDRAWN: The antitumor efficacy of docetaxel is enhanced by encapsulation in novel amphiphilic polymer cholesterol-coupled TPGS micelles
WITHDRAWN: The antitumor efficacy of docetaxel is enhanced by encapsulation in novel amphiphilic polymer cholesterol-coupled TPGS micelles Open
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/wit…