Chaochao Tan
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View article: Screening of biomarkers for early diagnosis of trauma-induced coagulopathy based on untargeted metabolomics
Screening of biomarkers for early diagnosis of trauma-induced coagulopathy based on untargeted metabolomics Open
Objectives Trauma-induced coagulopathy (TIC) is an acute coagulation disorder characterized by massive bleeding following trauma and is a leading cause of mortality. However, current clinical methods are inadequate for predicting TIC onset…
View article: Association between long-term atherogenic index of plasma and carotid atherosclerosis: a prospective cohort study of a health examination population
Association between long-term atherogenic index of plasma and carotid atherosclerosis: a prospective cohort study of a health examination population Open
Background and aims The atherogenic index of plasma (AIP) has been proposed as a new biomarker for atherosclerosis and cardiovascular diseases. This study aimed to investigate the association between AIP and the incidence and progression o…
View article: Neutrophil CD64 index: a novel biomarker for risk stratification in acute pancreatitis
Neutrophil CD64 index: a novel biomarker for risk stratification in acute pancreatitis Open
Objective Effective early diagnosis and timely intervention in acute pancreatitis (AP) are essential for improving patient outcomes. This study aims to evaluate the clinical utility of the neutrophil CD64 index (nCD64) in stratifying patie…
View article: Long-term exposure to PM2.5 leads to mitochondrial damage and differential expression of associated circRNA in rat hepatocytes
Long-term exposure to PM2.5 leads to mitochondrial damage and differential expression of associated circRNA in rat hepatocytes Open
Fine particulate matter (PM 2.5 ) is one of the four major causes of mortality globally. The objective of this study was to investigate the mechanism underlying liver injury following exposure to PM 2.5 and the involvement of circRNA in it…
View article: Redox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis
Redox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis Open
Background Protein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic cancer development remains poorly understood. Methods and results In this study, we performe…
View article: Mutational spectrum for guiding the decision of adjuvant treatment in patients with resected biliary tract carcinoma
Mutational spectrum for guiding the decision of adjuvant treatment in patients with resected biliary tract carcinoma Open
Background Systemic chemotherapy or chemoradiation therapy has proven to be effective in treating advanced biliary tract carcinoma (BTC). However, its efficacy in the adjuvant setting remains controversial. Therefore, this study aimed to d…
View article: Characteristics of ST11 KPC‐2‐producing carbapenem‐resistant hypervirulent <i>Klebsiella pneumoniae</i> causing nosocomial infection in a Chinese hospital
Characteristics of ST11 KPC‐2‐producing carbapenem‐resistant hypervirulent <i>Klebsiella pneumoniae</i> causing nosocomial infection in a Chinese hospital Open
Background The purpose of our study is to analyze the microbiological and clinical characteristics of carbapenem‐resistant hypervirulent Klebsiella pneumoniae (CR‐hvKP) that causes nosocomial infection. Methods We collected the carbapenem‐…
View article: Alterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis
Alterations of Asymmetric Dimethylarginine (ADMA)-Containing Protein Profiles Associated with Chronic Pancreatitis Pathogenesis Open
The pathogenesis of CP is associated with alterations of asymmetric arginine dimethylation in pancreatic tissues.
View article: Changes of serum IL‐10, IL‐1β, IL‐6, MCP‐1, TNF‐α, IP‐10 and IL‐4 in COVID‐19 patients
Changes of serum IL‐10, IL‐1β, IL‐6, MCP‐1, TNF‐α, IP‐10 and IL‐4 in COVID‐19 patients Open
The detection of IL-10, IL-1 β, IL-6, MCP-1, TNF-α and IL-4 would assist the clinical study of COVID-19, and IP-10 may be the cytokine of early elevation in COVID-19 patients.
View article: Cost-effectiveness analysis of pembrolizumab plus chemotherapy as first-line therapy for extensive-stage small-cell lung cancer
Cost-effectiveness analysis of pembrolizumab plus chemotherapy as first-line therapy for extensive-stage small-cell lung cancer Open
Background The phase III KEYNOTE-604 study confirmed the benefit of pembrolizumab combined with chemotherapy in the first-line treatment of extensive-stage small-cell lung cancer (ES-SCLC). Taken into account the clinical benefits of pembr…
View article: Proteome-Wide Alterations of Asymmetric Arginine Dimethylation Associated With Pancreatic Ductal Adenocarcinoma Pathogenesis
Proteome-Wide Alterations of Asymmetric Arginine Dimethylation Associated With Pancreatic Ductal Adenocarcinoma Pathogenesis Open
Arginine methylation catalyzed by protein arginine methyltransferases (PRMTs) performs essential roles in regulating cancer initiation and progression, but its implication in pancreatic ductal adenocarcinoma (PDAC) requires further elucida…
View article: C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early
C‐reactive protein correlates with computed tomographic findings and predicts severe COVID‐19 early Open
COVID‐19 has developed into a worldwide pandemic; early identification of severe illness is critical for controlling it and improving the prognosis of patients with limited medical resources. The present study aimed to analyze the characte…
View article: Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients
Hyperhomocysteinemia Associated with Multiple Organ Failure in Acute Pancreatitis Patients Open
Objective . This study aimed to evaluate the potential effect of hyperhomocysteinemia on multiple organ failure (MOF) in patients with acute pancreatitis (AP). Method . In this cohort study, a total of 1880 AP patients were enrolled and di…
View article: 2019 Novel Coronavirus (COVID-19) Pneumonia with Hemoptysis as the Initial Symptom: CT and Clinical Features
2019 Novel Coronavirus (COVID-19) Pneumonia with Hemoptysis as the Initial Symptom: CT and Clinical Features Open
Recently, some global cases of 2019 novel coronavirus (COVID-19) pneumonia have been caused by second- or third-generation transmission of the viral infection, resulting in no traceable epidemiological history. Owing to the complications o…
View article: Extensive protein S-nitrosylation associated with human pancreatic ductal adenocarcinoma pathogenesis
Extensive protein S-nitrosylation associated with human pancreatic ductal adenocarcinoma pathogenesis Open
NO (nitric oxide)-mediated protein S -nitrosylation has been established as one major signaling mechanism underlying cancer initiation and development, but its roles in PDAC (pancreatic ductal adenocarcinoma) pathogenesis still remain larg…
View article: Differentiating origins of outflow tract ventricular arrhythmias: a comparison of three different electrocardiographic algorithms
Differentiating origins of outflow tract ventricular arrhythmias: a comparison of three different electrocardiographic algorithms Open
Our objective is to evaluate the accuracy of three algorithms in differentiating the origins of outflow tract ventricular arrhythmias (OTVAs). This study involved 110 consecutive patients with OTVAs for whom a standard 12-lead surface elec…