Chaochu Cui
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View article: Parents' perceptions of physical activity for their children with cancer: a qualitative meta-synthesis
Parents' perceptions of physical activity for their children with cancer: a qualitative meta-synthesis Open
Background The the number of cases of cancer in children is increasing annually. Physical activity (PA) can enhance the future outcomes and quality of life of children with cancer. However, studies have shown that children with cancer have…
View article: PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer
PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer Open
Cancer remains the foremost cause of mortality on a global scale. Immunotherapy has yielded remarkable outcomes in the fight against cancer and is regarded as one of the most crucial and promising therapeutic modalities. PCSK9, a critical …
View article: The pleiotropic effects of PCSK9 in cardiovascular diseases beyond cholesterol metabolism
The pleiotropic effects of PCSK9 in cardiovascular diseases beyond cholesterol metabolism Open
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality globally, with elevated low‐density lipoprotein cholesterol (LDL‐C) levels being a major risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9) play…
View article: Research Progress on the Pharmacological Effects and Molecular Mechanisms of Pinostrobin
Research Progress on the Pharmacological Effects and Molecular Mechanisms of Pinostrobin Open
Pinostrobin (5-hydroxy-7-methoxyflavanone) is an active flavonoid substance. It is widely present in many traditional Chinese herbs, including Carya cathayensis leaves, Boesenbergia rotunda and propolis. Pinostrobin possesses many pharmaco…
View article: Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets
Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets Open
Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transition, metabolic remodeling, cancer cell in…
View article: Autophagy of umbilical cord mesenchymal stem cells conduces to pro-angiogenic function of conditioned medium
Autophagy of umbilical cord mesenchymal stem cells conduces to pro-angiogenic function of conditioned medium Open
BackgroundAngiogenesis is a key prerequisite for wound healing. The conditioned medium following culture of umbilical cord mesenchymal stem cells (UCMSCs) has a potential to promote angiogenesis, but the efficacy is very low. Autophagy is …
View article: Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease
Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease Open
Background: There is a significant gender difference in the incidence and symptoms of Alzheimer's disease (AD), but its mechanisms are not completely understood. Recent studies showed that NLRP1 inflammasome was overexpressed in females un…
View article: Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis
Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis Open
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological condit…
View article: Progress in understanding mitochondrial calcium uniporter complex‐mediated calcium signalling: A potential target for cancer treatment
Progress in understanding mitochondrial calcium uniporter complex‐mediated calcium signalling: A potential target for cancer treatment Open
Due to its Ca 2+ buffering capacity, the mitochondrion is one of the most important intracellular organelles in regulating Ca 2+ dynamic oscillation. Mitochondrial calcium uniporter (MCU) is the primary mediator of Ca 2+ influx into mitoch…
View article: PCI29732, a Bruton’s Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells
PCI29732, a Bruton’s Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells Open
Background/Aims: Multidrug resistance (MDR) induced by the ABC transporter subfamily B member 1 (ABCB1) and subfamilyG member 2 (ABCG2) limits successful cancer chemotherapy and no commercially available MDR modulator is used in the clinic…
View article: Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1
Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1 Open
Zinc, an essential micronutrient, has a cancer preventive role. Zinc deficiency has been shown to contribute to the progression of esophageal cancer. Orai1, a store‐operated Ca 2+ entry (SOCE) channel, was previously reported to be highly …