Explanipedia

The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis Open

Xi Chen, Huiqiao Li, Yanru Deng, Meng Jiang, Shangang Zhao , et al. · 2025

4-Methylumbelliferone (4-MU) is the active component of hymecromone, a choleretic and antispasmodic drug with an excellent safety profile. In rodent studies, high doses of 4-MU are also used to inhibit the production of hyaluronan (HA), a …

The potential of 4-Methylumbelliferone to be repurposed for treating liver fibrosis Open

Xi Chen, Huiqiao Li, Yanru Deng, Meng Jiang, Shangang Zhao , et al. · 2025

4-Methylumbelliferone (4-MU) is the active component of hymecromone, a choleretic and antispasmodic drug with an excellent safety profile. In rodent studies, high doses of 4-MU are also used to inhibit the production of hyaluronan (HA), a …

Retraction notice to "Predictive modeling the probability of suffering from metabolic syndrome using machine learning: A population-based study" [Heliyon 8 (2022) e12343] Open

Xiang Hu, Xue-Ke Li, Shiping Wen, Xingyu Li, Tianshu Zeng , et al. · 2025

[This retracts the article DOI: 10.1016/j.heliyon.2022.e12343.].

Role of Cancer History in Cardiovascular Mortality Among Different Age-group Patients With Differentiated Thyroid Cancer Open

Huajie Qiu, Wenyi Zhou, Qizhi Huang, Hongwei Lin, Yubo Zhou , et al. · 2024

Background Cardiovascular disease (CVD) is the leading cause of noncancer-related mortality among differentiated thyroid cancer (DTC) survivors, which accounts for a large portion of subsequent primary malignancies in childhood cancer surv…

HFD feeding for seven months abolishes STING disruption-driven but not female sex-based protection against hepatic steatosis and inflammation in mice Open

Xinlei Guo, Honggui Li, Bilian Zhu, Xiaoxiao Wang, Qian Xu , et al. · 2024

An essential role for hepatocyte adenosine kinase in regulating fat metabolism and inflammation Open

Jiayu Yu, Juan Zheng, Chaodong Wu · 2024

Editorial: The 4th NACAN summit proceedings: nutrition and food for a healthy life Open

Zhi Chai, Lei Hao, Sheau C. Chai, Guoxun Chen, Fanbin Kong , et al. · 2023

EDITORIAL article Front. Nutr., 04 May 2023Sec. Nutritional Epidemiology Volume 10 - 2023 | https://doi.org/10.3389/fnut.2023.1200954

miR-34a regulates macrophage-associated inflammation and angiogenesis in alcohol-induced liver injury Open

Ying Wan, Elise Slevin, Sachiko Koyama, Chiung‐Kuei Huang, Ashok K. Shetty , et al. · 2023

Background: Alcohol-associated liver disease (ALD) is a syndrome of progressive inflammatory liver injury and vascular remodeling associated with long-term heavy intake of ethanol. Elevated miR-34a expression, macrophage activation, and li…

Mini review: STING activation during non-alcoholic fatty liver disease Open

Honggui Li, Xinlei Guo, Eduardo Aquino, Chaodong Wu · 2023

Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic diseases serving as a major threat to human health. While the pathogenesis of NAFLD is multi-factorial, inflammation is considered a critical factor driving the de…

p16 INK4A drives nonalcoholic fatty liver disease phenotypes in high fat diet fed mice through biliary E2F1/FOXO1/IGF-1 signaling Open

Debjyoti Kundu, Lindsey Kennedy, Tianhao Zhou, Burcin Ekser, Vik Meadows , et al. · 2023

Background and Aims: NAFLD is characterized by steatosis, hepatic inflammation, and fibrosis, which can develop into NASH. Patients with NAFLD/NASH have increased ductular reaction (DR) and biliary senescence. High fat/high cholesterol die…

Dysbiosis in gastrointestinal pathophysiology: Role of the gut microbiome in Gulf War Illness Open

Elise Slevin, Sachiko Koyama, Kelly Harrison, Ying Wan, James E. Klaunig , et al. · 2023

Gulf War Illness (GWI) has been reported in 25%–35% of veterans returned from the Gulf war. Symptoms of GWI are varied and include both neurological and gastrointestinal symptoms as well as chronic fatigue. Development of GWI has been asso…

Knockout of secretin ameliorates biliary and liver phenotypes during alcohol-induced hepatotoxicity Open

Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Guido Carpino, Leonardo Baiocchi , et al. · 2023

Ghrelin Alleviates Experimental Ulcerative Colitis in Old Mice and Modulates Colonocyte Metabolism via PPARγ Pathway Open

Srilakshmi Muthyala, Robert S. Chapkin, Chaodong Wu, Chia‐Shan Wu · 2022

There is a growing prevalence of inflammatory bowel disease (IBD), a chronic inflammatory condition of the gastrointestinal tract, among the aging population. Ghrelin is a gut hormone that, in addition to controlling feeding and energy met…

Osr1 Regulates Macrophage-mediated Liver Inflammation in Nonalcoholic Fatty Liver Disease Progression Open

Lin Liu, Yi Zhou, Zhimin Liu, Jiangyuan Li, Linghao Hu , et al. · 2022

RETRACTED: Predictive modeling the probability of suffering from metabolic syndrome using machine learning: A population-based study Open

Xiang Hu, Xue-Ke Li, Shiping Wen, Xingyu Li, Tianshu Zeng , et al. · 2022

Hepatocyte Adenosine Kinase Promotes Excessive Fat Deposition and Liver Inflammation Open

Honggui Li, Juan Zheng, Qian Xu, Yongjian Yang, Jing Zhou , et al. · 2022

Editorial: The relationship between sarcopenia and metabolic diseases: Its formation mechanism and intervention means Open

Qingfeng Cheng, Chaodong Wu, Lixin Guo, Jinbo Hu · 2022

hormone and DHEAS levels in elderly men. If the study is confirmed in a larger population, the results obtained may shift the paradigm of drug intervention strategy of sarcopenia [22] . The Ghrelin secret-promoting agent capromorelin incre…

Molecular Mechanisms Linking Risk Factors to Cholangiocarcinoma Development Open

Ludovica Ceci, Tianhao Zhou, Ilaria Lenci, Vik Meadows, Lindsey Kennedy , et al. · 2022

The poor prognosis of cholangiocarcinoma in humans is related to several factors, such as (i) the heterogeneity of the disease, (ii) the late onset of symptoms and (iii) the limited comprehension of the carcinogenic pathways determining ne…

FGF1 Signaling Modulates Biliary Injury and Liver Fibrosis in the Mdr2−/− Mouse Model of Primary Sclerosing Cholangitis Open

April O’Brien, Tianhao Zhou, Tori White, Abigail Medford, Lixian Chen , et al. · 2022

Fibroblast growth factor 1 (FGF1) belongs to a family of growth factors involved in cellular growth and division. MicroRNA 16 (miR‐16) is a regulator of gene expression, which is dysregulated during liver injury and insult. However, the ro…

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP Open

Vik Meadows, Leonardo Baiocchi, Debjyoti Kundu, Keisaku Sato, Yessenia Fuentes , et al. · 2021

Cellular senescence is a pathophysiological phenomenon in which proliferative cells enter cell cycle arrest following DNA damage and other stress signals. Natural, permanent DNA damage can occur after repetitive cell division; however, acu…

Recent Advances in Adipose Tissue Dysfunction and Its Role in the Pathogenesis of Non-Alcoholic Fatty Liver Disease Open

Xiaoxiao Wang, Huiying Rao, Feng Liu, Lai Wei, Honggui Li , et al. · 2021

Obesity is a serious ongoing health problem that significantly increases the incidence of nonalcoholic fatty liver disease (NAFLD). During obesity, adipose tissue dysfunction is obvious and characterized by increased fat deposition (adipos…

Ketogenic Diets and Cardio-Metabolic Diseases Open

Weiyue Zhang, Xin Guo, Lulu Chen, Ting Chen, Jiayu Yu , et al. · 2021

While the prevalence of cardio-metabolic diseases (CMDs) has become a worldwide epidemic, much attention is paid to managing CMDs effectively. A ketogenic diet (KD) constitutes a high-fat and low-carbohydrate diet with appropriate protein …

Advances in Unhealthy Nutrition and Circadian Dysregulation in Pathophysiology of NAFLD Open

Xin Guo, Juan Zheng, Shixiu Zhang, Xiaofan Jiang, Ting Chen , et al. · 2021

Unhealthy diets and lifestyle result in various metabolic conditions including metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Much evidence indicates that disruption of circadian rhythms contributes to the development an…

Table of Contents Open

Chhavi Chauhan, Rama R. Gullapalli, Jerome Cheng, Jacob T. Abel, Ulysses J. Balis , et al. · 2021

The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice Open

Xiaojing Lin, Ying Zhang, Xiaoling He, Yan Chen, Nan Chen , et al. · 2021

Choline metabolite Trimethylamine N-oxide (TMAO) has been recognized as a risk factor of gestational diabetes mellitus (GDM), but its exact role in GDM has not been reported. In this study, we focused on the placenta development to reveal …

The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice Open

Xiaojing Lin, Ying Zhang, Xiaoling He, Yan Chen, Nan Chen , et al. · 2021

Choline metabolite Trimethylamine N-oxide (TMAO) has been recognized as a risk factor of gestational diabetes mellitus (GDM), but its exact role in GDM has not been reported. In this study, we focused on the placenta development to reveal …

The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice Open

Xiaojing Lin, Ying Zhang, Xiaoling He, Yan Chen, Nan Chen , et al. · 2021

Choline metabolite trimethylamine N-oxide (TMAO) has been recognized as a risk factor of gestational diabetes mellitus (GDM), but its exact role in GDM has not been reported. In this study, we focused on the placenta development to reveal …

Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression Open

Shengchen Lin, Yunzhan Li, Dezhen Wang, Chongbiao Huang, David Marino , et al. · 2021

Ectopic Overexpression of PPARγ2 in the Heart Determines Differences in Hypertrophic Cardiomyopathy After Treatment With Different Thiazolidinediones in a Mouse Model of Diabetes Open

Xuemei Cao, Min Mao, Junlin Diao, Yi Hou, Su Hong , et al. · 2021

The clinical controversy of rosiglitazone as a hypoglycemic agent is potentially associated with heart failure, mainly due to its potent activation of peroxisome proliferator-activated receptor γ (PPARγ). PPARγ partial agonists showed supe…

Methionine- and Choline-Deficient Diet–Induced Nonalcoholic Steatohepatitis Is Associated with Increased Intestinal Inflammation Open

Destiny Matthews, Honggui Li, Jing Zhou, Qingsheng Li, Shannon Glaser , et al. · 2021

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