Chuyu Pan
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View article: Gut microbiota–derived metabolites in immunomodulation and gastrointestinal cancer immunotherapy
Gut microbiota–derived metabolites in immunomodulation and gastrointestinal cancer immunotherapy Open
Gut microbiota-derived metabolites have emerged as critical mediators linking microbial composition with immune regulation and tumor progression in gastrointestinal (GI) cancers. This review highlights four major classes of metabolites: sh…
View article: Finerenone Targeting the Mineralocorticoid Receptor: Therapeutic Potential for Cardiorenal Syndrome
Finerenone Targeting the Mineralocorticoid Receptor: Therapeutic Potential for Cardiorenal Syndrome Open
Cardiorenal syndrome (CRS) is a complex clinical and pathological condition characterized by the dysfunction of either the heart or the kidney, leading to subsequent dysfunction in the other organ in the context of acute or chronic functio…
View article: Correlation between hemoglobin-to-albumin ratio and complications after radical gastrectomy in gastric cancer patients
Correlation between hemoglobin-to-albumin ratio and complications after radical gastrectomy in gastric cancer patients Open
Background Patients who undergo radical gastrectomy for gastric cancer often experience multiple complications that affect the recovery process and reduce quality of life. The hemoglobin-to-albumin ratio (HAR) reflects nutritional status a…
View article: Nomogram based on the novel index LANR, composed of preoperative lymphocytes, albumin, and neutrophils, for predicting prognosis in patients with gastric cancer: a retrospective study
Nomogram based on the novel index LANR, composed of preoperative lymphocytes, albumin, and neutrophils, for predicting prognosis in patients with gastric cancer: a retrospective study Open
Purpose This study aims to explore the relationship between the novel index LANR, which is composed of preoperative lymphocytes, neutrophils, and albumin, and prognosis in patients with gastric cancer (GC), and to develop and visualize a n…
View article: Associations of residential greenness with incident vascular diseases in middle-aged and older adults: A large prospective cohort study
Associations of residential greenness with incident vascular diseases in middle-aged and older adults: A large prospective cohort study Open
The relationship between residential greenness and chronic vascular diseases (VD) remains inconclusive. This study aimed to assess the associations between residential greenness and the incidence of new-onset VD. We analyzed data from a co…
View article: Global burden of diabetes mellitus 1990–2021: epidemiological trends, geospatial disparities, and risk factor dynamics
Global burden of diabetes mellitus 1990–2021: epidemiological trends, geospatial disparities, and risk factor dynamics Open
Diabetes mellitus(DM) remains a significant global health challenge, characterized by high incidence and Disability-adjusted life years (DALYs) rates. A comprehensive understanding of the disease burden of DM is crucial for developing effe…
View article: Multi-Granularity Open Intent Classification via Adaptive Granular-Ball Decision Boundary
Multi-Granularity Open Intent Classification via Adaptive Granular-Ball Decision Boundary Open
Open intent classification is critical for the development of dialogue systems, aiming to accurately classify known intents into their corresponding classes while identifying unknown intents. Prior boundary-based methods assumed known inte…
View article: The changing trend and prediction of the burden of anxiety disorder in Chinese population from 2022 to 2035
The changing trend and prediction of the burden of anxiety disorder in Chinese population from 2022 to 2035 Open
Objective To analyze the disease burden of anxiety disorders globally, in middle SDI countries, and in China using GBD public database. Methods Data on anxiety disorders were extracted from the GBD database, and GBDR_V2.36 was used for dat…
View article: Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts
Combined social determinants of health contributed to adverse health outcomes among depression: evidence from two national cohorts Open
Aims Social determinants of health (SDHs) exert a significant influence on various health outcomes and disparities. This study aimed to explore the associations between combined SDHs and mortality, as well as adverse health outcomes among …
View article: Multi-Granularity Open Intent Classification via Adaptive Granular-Ball Decision Boundary
Multi-Granularity Open Intent Classification via Adaptive Granular-Ball Decision Boundary Open
Open intent classification is critical for the development of dialogue systems, aiming to accurately classify known intents into their corresponding classes while identifying unknown intents. Prior boundary-based methods assumed known inte…
View article: Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study
Long-term ambient air pollution and the risk of major mental disorder: A prospective cohort study Open
Background Despite growing awareness of the mental health damage caused by air pollution, the epidemiologic evidence on impact of air pollutants on major mental disorders (MDs) remains limited. We aim to explore the impact of various air p…
View article: A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders
A prospective study of associations between accelerated biological aging and twenty musculoskeletal disorders Open
Accelerated biological aging is significantly associated with the incidence of several musculoskeletal disorders. These insights highlight the importance of biological age assessments in gauging musculoskeletal disorder risk, aiding early …
View article: Causal relationships between depression, emotional changes, and hiatal hernia: A Mendelian randomization analysis
Causal relationships between depression, emotional changes, and hiatal hernia: A Mendelian randomization analysis Open
Hiatal hernia (HH) is a common gastrointestinal disorder characterized by the displacement of abdominal contents, particularly the stomach, into the thoracic cavity. This condition is frequently associated with gastroesophageal reflux dise…
View article: Dual Regulation of Sensitizers and Cluster Catalysts in Metal–Organic Frameworks to Boost H<sub>2</sub> Evolution
Dual Regulation of Sensitizers and Cluster Catalysts in Metal–Organic Frameworks to Boost H<sub>2</sub> Evolution Open
Photocatalytic efficiency is closely correlated to visible‐light absorption ability, electron transfer efficiency and catalytic center activity of photocatalysts, nevertheless, the concurrent management of these factors to improve photocat…
View article: A genome-wide gene-environmental interaction study identified novel loci for the relationship between ambient air pollution exposure and depression, anxiety
A genome-wide gene-environmental interaction study identified novel loci for the relationship between ambient air pollution exposure and depression, anxiety Open
Our study identified the joint effects of air pollution with genetic susceptibility on the risk of depression and anxiety, and provided several novel candidate genes for the interaction, contributing to an understanding of the genetic arch…
View article: Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease
Potential involvement of connective tissue growth factor in chondrocytes apoptosis of Kashin-Beck disease Open
CTGF plays a crucial role in the development of KBD. Curcumin has shown potential in inhibiting CTGF levels and reducing chondrocyte apoptosis, highlighting its promise as a therapeutic agent for preventing cartilage damage in KBD. Our fin…
View article: Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study
Micronutrient-Associated Single Nucleotide Polymorphism and Mental Health: A Mendelian Randomization Study Open
Purpose: Previous studies have demonstrated the link between micronutrients and mental health. However, it remains uncertain whether this connection is causal. We aim to investigate the potential causal effects of micronutrients on mental …
View article: A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals
A genome-wide association study identifies candidate genes for sleep disturbances in depressed individuals Open
Objective This study aimed to identify candidate loci and genes related to sleep disturbances in depressed individuals and clarify the co-occurrence of sleep disturbances and depression from the genetic perspective. Methods The study subje…
View article: Mendelian randomization study of the relationship between blood and urine biomarkers and schizophrenia in the UK Biobank cohort
Mendelian randomization study of the relationship between blood and urine biomarkers and schizophrenia in the UK Biobank cohort Open
Background The identification of suitable biomarkers is of crucial clinical importance for the early diagnosis of treatment-resistant schizophrenia (TRS). This study aims to comprehensively analyze the association between TRS and blood and…
View article: Enhanced polygenic risk score incorporating gene–environment interaction suggests the association of major depressive disorder with cardiac and lung function
Enhanced polygenic risk score incorporating gene–environment interaction suggests the association of major depressive disorder with cardiac and lung function Open
Background Depression has been linked to an increased risk of cardiovascular and respiratory diseases; however, its impact on cardiac and lung function remains unclear, especially when accounting for potential gene–environment interactions…
View article: A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study
A multidimensional social risk atlas of depression and anxiety: An observational and genome-wide environmental interaction study Open
Our findings reveal the positive effects of multidimensional social factors on the risk of depression and anxiety. It is important to address key social disadvantage in mental health promotion and treatment.
View article: Insight into the Causal Relationship between Gut Microbiota and Back Pain: A Two Sample Bidirectional Mendelian Randomization Study
Insight into the Causal Relationship between Gut Microbiota and Back Pain: A Two Sample Bidirectional Mendelian Randomization Study Open
Observational studies have shown that alterations in gut microbiota composition are associated with low back pain. However, it remains unclear whether the association is causal. To reveal the causal association between gut microbiota and l…
View article: Dissecting the Association between Gut Microbiota and Brain Structure Change Rate: A Two-Sample Bidirectional Mendelian Randomization Study
Dissecting the Association between Gut Microbiota and Brain Structure Change Rate: A Two-Sample Bidirectional Mendelian Randomization Study Open
The connection between the gut microbiota and brain structure changes is still unclear. We conducted a Mendelian randomization (MR) study to examine the bidirectional causality between the gut microbiota (211 taxa, including 131 genera, 35…
View article: Associations of classical <scp>HLA</scp> alleles with depression and anxiety
Associations of classical <span>HLA</span> alleles with depression and anxiety Open
Immune dysregulation has been widely observed in patients with psychiatric disorders. This study aims to examine the association between HLA alleles and depression and anxiety. Using data from the UK Biobank, we performed regression analys…
View article: Exome‐wide screening identifies novel susceptibility genes for subjective well‐being
Exome‐wide screening identifies novel susceptibility genes for subjective well‐being Open
Appendix S1. Supplemental Methods. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the cor…
View article: Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort
Evaluating the role of anxiety on the association between irritable bowel syndrome and brain volumes: a mediation analysis in the UK Biobank cohort Open
There is a strong link between irritable bowel syndrome and brain volumes, yet, to date, research examining the mediators of this association has been little. Based on the phenotypic data of 15 248 participants from the UK Biobank, a two-s…
View article: GWAS summary data for SSC and addiction
GWAS summary data for SSC and addiction Open
The GWAS summary data for SSCs(p<5e-8) and addictions.