Chaofei Yang
YOU?
Author Swipe
View article: AdaTT: Adaptive Task-to-Task Fusion Network for Multitask Learning in Recommendations
AdaTT: Adaptive Task-to-Task Fusion Network for Multitask Learning in Recommendations Open
Multi-task learning (MTL) aims to enhance the performance and efficiency of machine learning models by simultaneously training them on multiple tasks. However, MTL research faces two challenges: 1) effectively modeling the relationships be…
View article: Transfer RNAs-derived small RNAs and their application potential in multiple diseases
Transfer RNAs-derived small RNAs and their application potential in multiple diseases Open
The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which tRNA outstands by its role o…
View article: MACF1 Deficiency Suppresses Tooth Mineralization through IGF1 mediated Crosstalk Between Odontoblasts and Ameloblasts
MACF1 Deficiency Suppresses Tooth Mineralization through IGF1 mediated Crosstalk Between Odontoblasts and Ameloblasts Open
Tooth mineralization is a ubiquitous and tightly regulated process in vertebrates which usually share the similar mechanisms of bone mineralization. However, key molecules in tooth mineralization remain poorly identified. Previously, we sh…
View article: MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss
MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss Open
Senile osteoporosis is one of the major health problems in an aging society. Decreased bone formation due to osteoblast dysfunction may be one of the causes of aging-related bone loss. With increasing evidence suggesting that multiple micr…
View article: Targeting long noncoding RNA PMIF facilitates osteoprogenitor cells migrating to bone formation surface to promote bone formation during aging
Targeting long noncoding RNA PMIF facilitates osteoprogenitor cells migrating to bone formation surface to promote bone formation during aging Open
Rationale: The migration of mesenchymal osteoprogenitor cells (OPCs) to bone formation surface is the initial step of osteoblastogenesis before they undergo osteoblast differentiation and maturation for governing bone formation. However, w…
View article: miR-129-5p Inhibits Bone Formation Through TCF4
miR-129-5p Inhibits Bone Formation Through TCF4 Open
Osteoporosis is a frequently occurring bone disease in middle-aged and aged men and women. However, current therapies on this disease are still not ideal. MicroRNAs (miRNAs) are a class of endogenous non-protein-coding RNA with a length of…
View article: Bone Microenvironment and Osteosarcoma Metastasis
Bone Microenvironment and Osteosarcoma Metastasis Open
The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is closely related to the bone microenvironment. Especially, the met…
View article: Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation
Mesenchymal MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation Open
Microtubule actin crosslinking factor 1 (MACF1) is a large crosslinker that contributes to cell integrity and cell differentiation. Recent studies show that MACF1 is involved in multiple cellular functions such as neuron development and ep…
View article: Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression
Recombinant Irisin Prevents the Reduction of Osteoblast Differentiation Induced by Stimulated Microgravity through Increasing β-Catenin Expression Open
Background: Irisin, a novel exercise-induced myokine, was shown to mediate beneficial effects of exercise in osteoporosis. Microgravity is a major threat to bone homeostasis of astronauts during long-term spaceflight, which results in decr…
View article: Investigation of interaction between <i>α</i>-Fe metal and H atom by ab-initio method
Investigation of interaction between <i>α</i>-Fe metal and H atom by ab-initio method Open
Hydrogen-induced cracking (HIC) is a key problem restricting the application of ultra-high strength steel. It is necessary to analyze the distribution of diffusible hydrogen to reveal the mechanism of HIC. The site occupation tendency of H…
View article: Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli
Silencing of miR-138-5p sensitizes bone anabolic action to mechanical stimuli Open
Emerging evidence is revealing that microRNAs (miRNAs) play essential roles in mechanosensing for regulating osteogenesis. However, no mechanoresponsive miRNAs have been identified in human bone specimens. Methods: Bedridden and aged patie…
View article: MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1
MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1 Open
Microtubule actin crosslinking factor 1 (MACF1) is a widely expressed cytoskeletal linker and plays essential role in various cells function by mediating cytoskeleton organization and dynamics. However, the function of MACF1 on preosteobla…
View article: Circulating miR-181c-5p and miR-497-5p Are Potential Biomarkers for Prognosis and Diagnosis of Osteoporosis
Circulating miR-181c-5p and miR-497-5p Are Potential Biomarkers for Prognosis and Diagnosis of Osteoporosis Open
Context Osteoporosis is a degenerative bone disease in aging men and women. MiRNAs associated with progressive bone loss in osteoporosis had not been clearly demonstrated. Objective The evaluation of the differentially expressed miRNAs in …
View article: Silencing of lncRNA AK045490 Promotes Osteoblast Differentiation and Bone Formation via β-Catenin/TCF1/Runx2 Signaling Axis
Silencing of lncRNA AK045490 Promotes Osteoblast Differentiation and Bone Formation via β-Catenin/TCF1/Runx2 Signaling Axis Open
Osteoporosis, a disease characterized by both loss of bone mass and structural deterioration of bone, is the most common reason for a broken bone among the elderly. It is known that the attenuated differentiation ability of osteogenic cell…
View article: MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice
MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice Open
MACF1 is a large crosslinker that contributes to cytoskeleton integrity and cell differentiation. Loss of MACF1 impairs multiple cellular functions in neuron development and epidermal migration, and is the molecular basis for many diseases…
View article: Molecular Regulation of Catalpol and Acteoside Accumulation in Radial Striation and non-Radial Striation of Rehmannia glutinosa Tuberous Root
Molecular Regulation of Catalpol and Acteoside Accumulation in Radial Striation and non-Radial Striation of Rehmannia glutinosa Tuberous Root Open
Rehmannia glutinosa L., a perennial plant of Scrophulariaceae, is one of the most commonly used herbs in traditional Chinese medicine (TCM) that have been widely cultivated in China. However, to date, the biosynthetic pathway of its two qu…
View article: Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy
Mesenchymal Stem Cell Migration during Bone Formation and Bone Diseases Therapy Open
During bone modeling, remodeling, and bone fracture repair, mesenchymal stem cells (MSCs) differentiate into chondrocyte or osteoblast to comply bone formation and regeneration. As multipotent stem cells, MSCs were used to treat bone disea…
View article: The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment
The Impact of Oxidative Stress on the Bone System in Response to the Space Special Environment Open
The space special environment mainly includes microgravity, radiation, vacuum and extreme temperature, which seriously threatens an astronaut’s health. Bone loss is one of the most significant alterations in mammalians after long-duration …