Chaofeng Han
YOU?
Author Swipe
View article: SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency
SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency Open
Premature ovarian insufficiency (POI) is a major cause of infertility and endocrine dysfunction, in which chronic inflammation plays a critical role. The homeostasis of tissue‐resident macrophages and monocyte‐differentiated macrophages fr…
View article: Epigenetic regulation of varicella-zoster virus infection: a systematic synthesis of mechanisms
Epigenetic regulation of varicella-zoster virus infection: a systematic synthesis of mechanisms Open
Background: Herpes zoster (HZ), resulting from varicella-zoster virus (VZV) reactivation, imposes a significant and growing public health burden, especially among aging populations. Viral epigenetics is crucial for understanding viral pers…
View article: IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous cell carcinoma
IL-4-STAT6-induced high Siglec-G/10 expression aggravates the severe immune suppressive tumor microenvironment and impedes the efficacy of immunotherapy in head and neck squamous cell carcinoma Open
Background Immune checkpoint blockade therapy has shown limited efficacy in head and neck squamous cell carcinoma (HNSCC). Sialic acid binding immunoglobulin-like lectin (Siglec)-15 has been identified as a novel immune evasion biomarker, …
View article: SIRT3 is required for the protective function of ketogenic diet on neural inflammation and neuropathic pain
SIRT3 is required for the protective function of ketogenic diet on neural inflammation and neuropathic pain Open
Chronic neuroinflammation is a key pathological feature of neuropathic pain. The ketogenic diet (KD) has demonstrated potential to reduce neuronal excitability and alleviate inflammation in epilepsy, yet its effects and precise mechanisms …
View article: SHP099-containing multi-targeting hydrogel promotes rapid skin reconstruction through modulating a variety of cells
SHP099-containing multi-targeting hydrogel promotes rapid skin reconstruction through modulating a variety of cells Open
Introduction Adult wound scarring result in functional skin deficits. However, the development of effective measures to modulate the entire wound healing to encourage the skin function reconstruction is still a clinical challenge, as multi…
View article: PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis
PRMT6 Epigenetically Drives Metabolic Switch from Fatty Acid Oxidation toward Glycolysis and Promotes Osteoclast Differentiation During Osteoporosis Open
Epigenetic regulation of metabolism profoundly influences cell fate commitment. During osteoclast differentiation, the activation of RANK signaling is accompanied by metabolic reprogramming, but the epigenetic mechanisms by which RANK sign…
View article: Hyperglycemia‐induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis
Hyperglycemia‐induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis Open
Background Hyperglycemia‐induced neuroinflammation significantly contributes to diabetic neuropathic pain (DNP), but the underlying mechanisms remain unclear. Objective To investigate the role of Sirt3, a mitochondrial deacetylase, in hype…
View article: Macrophage STING signaling promotes fibrosis in benign airway stenosis via IL6-STAT3 axis
Macrophage STING signaling promotes fibrosis in benign airway stenosis via IL6-STAT3 axis Open
Benign airway stenosis (BAS) caused by tracheal intubation resuscitation measures is a difficult complication to ignore in the management of critically ill patients. However, the pathogenesis of this disease, which is characterized histolo…
View article: Electrical/thermal triggering on shape memory composite tubes with different braiding angles
Electrical/thermal triggering on shape memory composite tubes with different braiding angles Open
2D braided shape memory composite (SMPC) tubes, with near-net shape manufacturing and programmable, are widely utilized in smart structures. Here we have developed braided tubes of continuous carbon fiber reinforced shape memory polyuretha…
View article: ISGylation by HERCs facilitates STING activation
ISGylation by HERCs facilitates STING activation Open
Optimal activation of stimulator of interferon genes (STING) protein is crucial for host defenses against pathogens and avoiding detrimental effects. Various post-translational modifications control STING activity. However, the function of…
View article: Changes in SLITRK1 Level in the Amygdala Mediate Chronic Neuropathic Pain-Induced Anxio-Depressive Behaviors in Mice
Changes in SLITRK1 Level in the Amygdala Mediate Chronic Neuropathic Pain-Induced Anxio-Depressive Behaviors in Mice Open
Background: Comorbid chronic neuropathic pain (NPP) and anxio-depressive disorders (ADD) have become a serious global public-health problem. The SLIT and NTRK-like 1 (SLITRK1) protein is important for synaptic remodeling and is highly expr…
View article: PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia
PRMT6 deficiency or inhibition alleviates neuropathic pain by decreasing glycolysis and inflammation in microglia Open
Microglia induced chronic inflammation is the critical pathology of Neuropathic pain (NP). Metabolic reprogramming of macrophage has been intensively reported in various chronic inflammation diseases. However, the metabolic reprogramming o…
View article: HSV-1 reactivation results in post-herpetic neuralgia by upregulating Prmt6 and inhibiting cGAS-STING
HSV-1 reactivation results in post-herpetic neuralgia by upregulating Prmt6 and inhibiting cGAS-STING Open
Chronic varicella zoster virus (VZV) infection induced neuroinflammatory condition is the critical pathology of post-herpetic neuralgia (PHN). The immune escape mechanism of VZV remains elusive. As to mice have no VZV infection receptor, h…
View article: Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis
Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis Open
The uncontrolled bacterial infection-induced cytokine storm and sequential immunosuppression are commonly observed in septic patients, which indicates that the activation of phagocytic cells and the efficient and timely elimination of bact…
View article: Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway
Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway Open
Background: The JAK/STAT signaling pathway is the main inflammatory signal transduction pathway, whether JAK/STAT contributes the pathology of SCI and targeting the pathway will alleviate SCI needs to be addressed. Here, we explored the th…
View article: i-CRISPR: a personalized cancer therapy strategy through cutting cancer-specific mutations
i-CRISPR: a personalized cancer therapy strategy through cutting cancer-specific mutations Open
Developing a strategy to specifically kill cancer cells without inducing obvious damage to normal cells may be of great clinical significance for cancer treatment. In the present study, we developed a new precise personalized strategy name…
View article: Additional file 2 of i-CRISPR: a personalized cancer therapy strategy through cutting cancer-specific mutations
Additional file 2 of i-CRISPR: a personalized cancer therapy strategy through cutting cancer-specific mutations Open
Additional file 2.
View article: Correction: Potentiation of tumor necrosis factor-α-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4
Correction: Potentiation of tumor necrosis factor-α-induced tumor cell apoptosis by a small molecule inhibitor for anti-apoptotic protein hPEBP4 Open
The IgG lanes of immunoblot panels Raf-1 and MEK-1 under DMSO in Fig. 6B contained blurred pixels. Both 90 minute timepoint bands in the p-IKK⍺/β immunoblots of Fig. 6C contained blurred pixels. The authors have provided new versions of th…
View article: Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses
Demalonylation of DDX3 by Sirtuin 5 promotes antiviral innate immune responses Open
Rationale: Hosts defend against viral infection by sensing viral pathogen-associated molecular patterns and activating antiviral innate immunity through TBK1-IRF3 signaling. However, the underlying molecular mechanism remains unclear. Meth…
View article: Correction: Tyrosine kinase Btk is required for NK cell activation.
Correction: Tyrosine kinase Btk is required for NK cell activation. Open
The legend for Fig. 6E contained an error.The legend should state "E, 18 h post-poly(I:C) (20 g/g body weight) challenge, liver sections
View article: Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation
Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation Open
Hyper-inflammation during acute phase and sequential hypo-inflammation during immunosuppressive phase in macrophages/monocytes lead to multiorgan failure syndrome and immune collapse of sepsis, in which toll-like receptor (TLR)-triggered i…
View article: An endosomal LAPF is required for macrophage endocytosis and elimination of bacteria
An endosomal LAPF is required for macrophage endocytosis and elimination of bacteria Open
Significance Host innate immune cells, such as macrophages, can endocytose the invading pathogens and induce inflammatory innate responses to fight infection. In this study, we show that a Cav1-interacting protein, LAPF, promotes the endoc…