Chaoqin Yu
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View article: Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility
Integrative Single‐Cell Analysis Reveals Iron Overload‐Induced Senescence and Metabolic Reprogramming in Ovarian Endometriosis‐Associated Infertility Open
Endometriosis, particularly ovarian endometriosis (OE), is a major cause of infertility, often associated with reduced oocyte quality and impaired ovarian function. Iron overload plays a key role in OE progression. This study investigates …
View article: Therapeutic effects and potential mechanisms of caffeine on obese polycystic ovary syndrome: bioinformatic analysis and experimental validation
Therapeutic effects and potential mechanisms of caffeine on obese polycystic ovary syndrome: bioinformatic analysis and experimental validation Open
The risk of PCOS is significantly increased in obese women, and studies have shown that weight loss can improve symptoms of PCOS. Coffee has been shown to be effective in reducing body weight. In this study, we focused on the SLC16A6 gene …
View article: Curcumin suppresses malignant behaviors of ovarian cancer through regulation of tumor-associated macrophages
Curcumin suppresses malignant behaviors of ovarian cancer through regulation of tumor-associated macrophages Open
View article: Prognostic role of tertiary lymphatic structures and their modulation by adjuvant FOLFOX in stage III colon cancer: a retrospective cohort study
Prognostic role of tertiary lymphatic structures and their modulation by adjuvant FOLFOX in stage III colon cancer: a retrospective cohort study Open
TLSs serve as a reliable, independent prognostic biomarker in stage III CC. Their spatial distribution carries distinct prognostic implications, and FOLFOX-induced TLS formation suggests a dual role in cytotoxicity and immune activation. I…
View article: Can iron serve as oocyte quality indicator in endometriosis?
Can iron serve as oocyte quality indicator in endometriosis? Open
Endometriosis (EMs) is a significant cause of female infertility, and recent attention has focused on the relationship between iron levels in follicular fluid (FF) and oocyte quality. This perspective summarizes the characteristics of alte…
View article: Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve
Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve Open
View article: Therapeutic effects and potential mechanisms of caffeine on obese polycystic ovary syndrome: bioinformatic analysis and experimental validation
Therapeutic effects and potential mechanisms of caffeine on obese polycystic ovary syndrome: bioinformatic analysis and experimental validation Open
Background The risk of PCOS is significantly increased in obese women, and studies have shown that weight loss can improve the symptoms of PCOS. Coffee has been shown to effectively reduce body weight. In this study, we focused on the SLC1…
View article: Knowledge about, attitudes toward and acceptance and predictors of intention to receive the mpox vaccine among cancer patients in China: A cross-sectional survey
Knowledge about, attitudes toward and acceptance and predictors of intention to receive the mpox vaccine among cancer patients in China: A cross-sectional survey Open
This study aimed to investigate the knowledge about, attitudes toward, and acceptance and predictors of receiving the mpox vaccine among Chinese cancer patients. Patients were selected using a convenience sampling method. A web-based self-…
View article: Can Tibetan medicine Honghua Ruyi pills relieve endometriosis-associated dysmenorrhea? Protocol for a randomized placebo-controlled trial
Can Tibetan medicine Honghua Ruyi pills relieve endometriosis-associated dysmenorrhea? Protocol for a randomized placebo-controlled trial Open
Objective: To provide high-quality clinical evidence of the efficacy of Tibetan medicine Honghua Ruyi (HHRY) pills for endometriosis-associated dysmenorrhea. Methods: This study constitutes a multicenter, randomized, double-blind, placebo-…
View article: Therapeutic effects of Huayu Jiedu formula on endometriosis via downregulating GATA 6 expression
Therapeutic effects of Huayu Jiedu formula on endometriosis via downregulating GATA 6 expression Open
We demonstrated that HYJDF has anti-inflammation activity and increased cell apoptosis through the reduction of GATA 6 expression in ectopic tissues, which showed good therapeutic effect without any obvious side effects. These findings sug…
View article: Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility
Double-edged roles of ferroptosis in endometriosis and endometriosis-related infertility Open
View article: Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis
Curcumin modulates oxidative stress to inhibit pyroptosis and improve the inflammatory microenvironment to treat endometriosis Open
View article: Characteristics and possible mechanisms of metabolic disorder in overweight women with polycystic ovary syndrome
Characteristics and possible mechanisms of metabolic disorder in overweight women with polycystic ovary syndrome Open
Background Polycystic ovary syndrome (PCOS) is a kind of endocrine and metabolic disorder, disturbing the females of reproductive age. Here, we aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze th…
View article: Huayu Jiedu Fang Protects Ovarian Function in Mouse with Endometriosis Iron Overload by Inhibiting Ferroptosis
Huayu Jiedu Fang Protects Ovarian Function in Mouse with Endometriosis Iron Overload by Inhibiting Ferroptosis Open
Endometriosis (EM) is a common chronic inflammatory disease in women. Sampson’s retrograde menstruation theory is the most widely accepted theory of EM pathogenesis. The periodic bleeding of ectopic lesions is an important pathological fea…
View article: Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity
Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity Open
View article: Therapeutic Prospects of Polysaccharides for Ovarian Cancer
Therapeutic Prospects of Polysaccharides for Ovarian Cancer Open
Ovarian cancer (OC) is ranked as the leading cause of death among cancers of the female reproductive tract. First-line platinum treatment faces the severe challenges associated with the patient relapse and poor prognosis. Thus, it is imper…
View article: Androgen Excess Induced Mitochondrial Abnormality in Ovarian Granulosa Cells in a Rat Model of Polycystic Ovary Syndrome
Androgen Excess Induced Mitochondrial Abnormality in Ovarian Granulosa Cells in a Rat Model of Polycystic Ovary Syndrome Open
Background Androgen excess could profoundly lead to follicular dysplasia or atresia, and finally result in polycystic ovary syndrome (PCOS); however, the exact mechanism remains to be fully elucidated. Methods PCOS model rats were induced …
View article: Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles
Impact of Maternal Age on Singleton Birthweight in Frozen Embryo Transfer Cycles Open
Background Previous studies have investigated the effect of maternal age on assisted reproductive technology success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embryo tran…
View article: Characteristics of Gut Microbiota and Its Relationship With Serum Sex Hormones in Non-obese Polycystic Ovary Syndrome Patients With Insulin Resistance
Characteristics of Gut Microbiota and Its Relationship With Serum Sex Hormones in Non-obese Polycystic Ovary Syndrome Patients With Insulin Resistance Open
Background: Insulin resistance (IR) is a common symptom in obese polycystic ovary syndrome (PCOS) patients, as well as in non-obese PCOS patients. Gut microbiota is closely related to IR. However, the relationship between gut microbiota an…
View article: Curcumin treats endometriosis in mice by the HIF signaling pathway.
Curcumin treats endometriosis in mice by the HIF signaling pathway. Open
Curcumin played a role in the treatment of EM by modulating the HIF signaling pathway, improving the local hypoxia of the lesion, and reducing the inflammatory state of EM.
View article: Mechanism of Thunberg Fritillaria in treating endometriosis based on network pharmacology and the effect of Peiminine on the MEK/ERK pathway.
Mechanism of Thunberg Fritillaria in treating endometriosis based on network pharmacology and the effect of Peiminine on the MEK/ERK pathway. Open
Overall, this study partially verified the network pharmacological prediction that Peiminine regulates the MAPK pathway in inhibiting 12Z cell proliferation and migration, and finally protects against EMs.
View article: Association between paternal age and singleton birthweight in frozen embryo transfer cycles
Association between paternal age and singleton birthweight in frozen embryo transfer cycles Open
View article: The Inflammatory Response Induced by RELMβ Upregulates IL-8 and IL-1β Expression in Bronchial Epithelial Cells in COPD
The Inflammatory Response Induced by RELMβ Upregulates IL-8 and IL-1β Expression in Bronchial Epithelial Cells in COPD Open
Li Che,1 Chao Yu,2 Guangshu Chen,3 Jiaxin Lin,1 Zhefan Xie,1 Tingting Xia,1 Wenzhi Luo,1 Xingdong Cai,1 Shengming Liu1 1Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, 51063…
View article: Impact of Buzhong Yiqi Prescription on the Gut Microbiota of Patients with Obesity Manifesting Polycystic Ovarian Syndrome
Impact of Buzhong Yiqi Prescription on the Gut Microbiota of Patients with Obesity Manifesting Polycystic Ovarian Syndrome Open
Gut microbiota disorders are closely related to polycystic ovarian syndrome (PCOS). Buzhong Yiqi prescription (BZYQ) has a significant clinical effect on the treatment of patients with obesity exhibiting PCOS and phlegm-dampness syndrome c…
View article: The Mechanism Exploration of Follicular Fluids on Granulose Cell Apoptosis in Endometriosis‐Associated Infertility
The Mechanism Exploration of Follicular Fluids on Granulose Cell Apoptosis in Endometriosis‐Associated Infertility Open
Objective . To explore the mechanisms of follicular fluids (FFs) on granulose cell (GC) apoptosis in endometriosis‐associated infertility. Materials and Methods . 60 infertile women were enrolled. The FFs from 30 endometriosis‐associated i…
View article: Self-Control Study on the Impact of Buzhong Yiqi Prescription on the Gut Microbiota of Obese Patients with PCOS and Phlegm-Dampness Syndrome Caused by Spleen Deficiency
Self-Control Study on the Impact of Buzhong Yiqi Prescription on the Gut Microbiota of Obese Patients with PCOS and Phlegm-Dampness Syndrome Caused by Spleen Deficiency Open
Background: Gut microbiota disorders have been closely related to polycystic ovarian syndrome (PCOS). Buzhong Yiqi prescription (BZYQ) has a great clinical effect on the treatment of obese patients with PCOS and phlegm-dampness syndrome ca…
View article: Impact of maternal age on birthweight in frozen embryo transfer cycles: an analysis including 12565 singleton newborns
Impact of maternal age on birthweight in frozen embryo transfer cycles: an analysis including 12565 singleton newborns Open
Background: Previous studies have investigated the effect of maternal age on assisted reproductive technology (ART) success rates. However, little is known about the relationship between maternal age and neonatal birthweight in frozen embr…
View article: Correlation Between Fecal Metabolomics and Gut Microbiota in Obesity and Polycystic Ovary Syndrome
Correlation Between Fecal Metabolomics and Gut Microbiota in Obesity and Polycystic Ovary Syndrome Open
Objective: This study aimed to explore the relationship between the fecal metabolites and gut microbiota in obese patients with PCOS and provide a new strategy to elucidate the pathological mechanism of obesity and PCOS. Methods:…
View article: Analysis of IVF/ICSI-FET Outcomes in Women With Advanced Endometriosis: Influence on Ovarian Response and Oocyte Competence
Analysis of IVF/ICSI-FET Outcomes in Women With Advanced Endometriosis: Influence on Ovarian Response and Oocyte Competence Open
Aims: To determine the impact of advanced endometriosis (EMS) on in vitro fertilization/intracytoplasmic sperm injection and frozen-thawed embryo transfer (IVF/ICSI-FET) outcomes and analyze the influencing factors. Method…
View article: Transferrin Insufficiency and Iron Overload in Follicular Fluid Contribute to Oocyte Dysmaturity in Infertile Women With Advanced Endometriosis
Transferrin Insufficiency and Iron Overload in Follicular Fluid Contribute to Oocyte Dysmaturity in Infertile Women With Advanced Endometriosis Open
Purpose: To screen out specific protein with different concentration in follicular fluid from advanced endometriosis and determine its direct effect on mouse oocytes matured in vitro. Methods: FF samples were obtained …