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Epidemiology and survival of patients with primary lymphoma of bone: a large retrospective cohort study Open

Xiaojie Liang, Weixiang Lu, Tong Li, Baiwei Luo, Yuzhe Wu , et al. · 2025

Medicine

Primary lymphoma of bone (PLB) is a rare extranodal lymphoma, and its epidemiology and prognosis remain controversial. We conducted a retrospective analysis of 1,222 patients with PLB in the Surveillance, Epidemiology, and End Results (SEE…

Overexpression of ornithine decarboxylase 1 mediates the immune-deserted microenvironment and poor prognosis in diffuse large B-cell lymphoma Open

Xiaojie Liang, Jia Guo, Xiaofang Wang, Baiwei Luo, Ruiying Fu , et al. · 2024

Biology

Our study effectively advances the precise risk stratification of DLBCL and reveals that ODC1 and immune-deserted microenvironment jointly shape a group of DLBCL patients with stem cell-like features. Targeting ODC1 regulates immunotherapi…

LRP12 is an endogenous transmembrane inactivator of α4 integrins Open

Mengwen Huang, Ling Lu, Changdong Lin, Yajuan Zheng, XingChao Pan , et al. · 2023

Chemistry Biology

Dynamic regulation of integrin activation and inactivation is critical for precisely controlled cell adhesion and migration in physiological and pathological processes. The molecular basis for integrin activation has been intensively studi…

Data from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Biology Chemistry Medicine

Immune cell infiltration is important for predicting the clinical outcomes of colorectal cancer. Integrin β7 (ITGB7), which is expressed on the surface of leukocytes, plays an essential role in the homing of immune cells to gut-associated …

Figure S7 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Biology Medicine Geography

Tumor tissue ITGB7 expression level represents the CD8+ T and B cell infiltration level, and the ITGB7 expression level on CD8+ T cells.

Figure S3 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine

Differentially expressed gene and gene ontology analysis.

Figure S4 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine

The correlation between ITGB7 expression and the expression of genes that are related to immunotherapy.

Figure S2 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Biology

The association between ITGB7 expression and survival, CMS types, and stages of CRC.

Figure S6 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine

β7 blockade decreased the number of migrated CD3+ T cells towards CRC-organoids.

Data from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Chemistry Biology Medicine

Immune cell infiltration is important for predicting the clinical outcomes of colorectal cancer. Integrin β7 (ITGB7), which is expressed on the surface of leukocytes, plays an essential role in the homing of immune cells to gut-associated …

Figure S5 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine

The expression pattern of α4β7 and αEβ7 in tumor infiltrating immune cells in WT mice bearing MC38 orthotopic tumor.

Figure S7 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Biology Materials science

Tumor tissue ITGB7 expression level represents the CD8+ T and B cell infiltration level, and the ITGB7 expression level on CD8+ T cells.

Figure S4 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine

The correlation between ITGB7 expression and the expression of genes that are related to immunotherapy.

Table S1 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Computer science

Supplementary Table 1

Figure S2 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Biology

The association between ITGB7 expression and survival, CMS types, and stages of CRC.

Figure S1 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Biology Geography

Immune cell infiltration in tumor and adjacent normal tissues from CRC patients.

Figure S5 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine

The expression pattern of α4β7 and αEβ7 in tumor infiltrating immune cells in WT mice bearing MC38 orthotopic tumor.

Figure S3 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine

Differentially expressed gene and gene ontology analysis.

Table S1 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Computer science

Supplementary Table 1

Figure S6 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Chemistry Biology

β7 blockade decreased the number of migrated CD3+ T cells towards CRC-organoids.

Figure S1 from Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2023

Medicine Materials science

Immune cell infiltration in tumor and adjacent normal tissues from CRC patients.

Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells Open

Chunye Liu, Changdong Lin, Daisong Wang, Jingqiang Wang, Tao Yu , et al. · 2022

Biology

The protein C receptor (Procr) has been implicated as a stem cell surface marker in several tissues. It is unknown whether Procr acts as a functional signaling receptor in stem cells. Here, by conditional knockout in mammary stem cells (Ma…

Population-based Seroprevalence Survey of COVID-19 Virus Infection in Malaysia Open

Changdong Lin, AM M Hatta, A. Noor Ani · 2021

Geography Biology Medicine

Results of population-based age stratified seroepidemiological investigation in Malaysia

Protocol for fever-range whole-body hyperthermia (WBH) in mice to study febrile effect on T-cell adhesion and migration Open

Changdong Lin, Zhaoyuan Liu, Yue Li, Jianfeng Chen · 2021

Medicine Chemistry

Fever is a complex physiological response enhancing immune surveillance during infection and inflammation. Fever-range whole-body hyperthermia (WBH) treatment can experimentally mimic the febrile condition in mice. Here, we describe a prot…

Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Antitumor Immunity Open

Youhua Zhang, Ruting Xie, Hailong Zhang, Yajuan Zheng, Changdong Lin , et al. · 2021

Medicine

Immune cell infiltration is important for predicting the clinical outcomes of colorectal cancer. Integrin β7 (ITGB7), which is expressed on the surface of leukocytes, plays an essential role in the homing of immune cells to gut-associated …

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