Explanipedia

Quantification of FDG in the spinal cord using PET/MRI Open

Eve Lennie, Steven Sourbron, Nigel Hoggard, Thomas M. Jenkins, Charalampos Tsoumpas · 2025

Background In this study, we investigate the impact of MR-derived attenuation maps and limited detector resolution on the quantification of positron emission tomography (PET) activity uptake in the spinal cord during PET/MRI. This was perf…

Neuroimaging Signatures of Temporomandibular Disorder and Burning Mouth Syndrome: A Systematic Review Open

Sarah Fischer, Charalampos Tsoumpas, Pavneet Chana, Richard Feltbower, Vishal R. Aggarwal · 2025

Background: Chronic primary orofacial pain (COFP) affects approximately 7% of the population and often leads to reduced quality of life. Patients frequently undergo multiple assessments and treatments across healthcare disciplines, often w…

Transient ischemic dilation ratio by [13N]NH3 PET/CT in patients with variable extent of myocardial ischemia: relevance of software package and quantification method Open

Tonantzin Samara Martínez-Lucio, Sergiy V. Lazarenko, Oscar Isaac Mendoza-Ibáñez, Remco J.J. Knol, Andrea G. Monroy‐Gonzalez , et al. · 2025

GATE 10 Monte Carlo particle transport simulation -- Part II: architecture and innovations Open

Nils Krah, Nicolas Arbor, Thomas Baudier, Julien Bert, Konstantinos Chatzipapas , et al. · 2025

Over the past years, we have developed GATE version 10, a major re-implementation of the long-standing Geant4-based Monte Carlo application for particle and radiation transport simulation in medical physics. This release introduces many ne…

GATE 10 Monte Carlo particle transport simulation -- Part I: development and new features Open

David Sarrut, Nicolas Arbor, Thomas Baudier, Julien Bert, Konstantinos Chatzipapas , et al. · 2025

We present GATE version 10, a major evolution of the open-source Monte Carlo simulation application for medical physics, built on Geant4. This release marks a transformative evolution, featuring a modern Python-based user interface, enhanc…

Quantification of 89Zr-immunoPET: Methodological considerations Open

Philipp Mohr, Joyce van Sluis, Adrienne H. Brouwers, Marjolijn N. Lub–de Hooge, Z. Li , et al. · 2025

Patlak analysis accounts for plasma kinetics and reversible signals, enabling more accurate interpretation of ⁸⁹Zr-immunoPET data than SUV. Wider use of kinetic modelling could enhance quantitative accuracy, support reinterpreta…

Evaluating image-derived input functions for cerebral [18F]MC225 PET studies Open

Giordana Salvi de Souza, Pascalle Mossel, Joost F. Somsen, Laura Providência, Anna L. Bartels , et al. · 2025

Kinetic modelling of brain PET data is crucial for estimating quantitative biological parameters, traditionally requiring arterial sampling. This study evaluated whether arterial samples could be omitted to estimate the image-derived input…

Separation of simultaneously acquired [89Zr]atezolizumab and [18F]FDG PET scans Open

Z. Li, Janneke de Boer, Tom van Meerten, Anne G.H. Niezink, Walter Noordzij , et al. · 2025

Exploratory Study of Sex Differences in P‐Glycoprotein Function at the Blood–Brain Barrier Open

Giordana Salvi de Souza, Wanling Liu, Pascalle Mossel, Joost F. Somsen, Anna L. Bartels , et al. · 2025

Permeability‐glycoprotein (P‐gp), a crucial efflux pump transporter encoded by the ABCB1 gene, plays a pivotal role in drug disposition at the blood–brain barrier (BBB) and is involved in the pharmacokinetics of numerous therapeutic agents…

Bayesian modeling with locally adaptive prior parameters in small animal imaging Open

Muyang Zhang, Robert G. Aykroyd, Charalampos Tsoumpas · 2025

Medical images are hampered by noise and relatively low resolution, which create a bottleneck in obtaining accurate and precise measurements of living organisms. Noise suppression and resolution enhancement are two examples of inverse prob…

Oral Administration of [18F]MC225 for Quantification of P-glycoprotein Function: A Feasibility Study Open

Giordana Salvi de Souza, Cristiane Regina Guerino Furini, Jürgen W. A. Sijbesma, Maria Kominia, Janine Doorduin , et al. · 2025

Purpose This preclinical study explored the feasibility of assessing P-glycoprotein (P-gp) function in both brain and gastrointestinal (GI) tract of rats using positron emission tomography (PET) following oral administration of [ 18 F]MC22…

Editorial: Nuclear medicine advances through artificial intelligence and intelligent informatics Open

Lisa Duff, Kuangyu Shi, Charalampos Tsoumpas · 2025

Ultrashort Oncologic Whole-Body [<sup>18</sup>F]FDG Patlak Imaging Using LAFOV PET Open

Joyce van Sluis, Johannes H. van Snick, Andor W.J.M. Glaudemans, Riemer H. J. A. Slart, Walter Noordzij , et al. · 2024

Methods to shorten [¹⁸F]FDG Patlak PET imaging procedures ranging from 65-90 to 20-30 min after injection, using a population-averaged input function (PIF) scaled to patient-specific image-derived input function (IDIF) values, w…

Evaluation of Automatic Segmentation Tools on Low-Dose and Ultra-Low-Dose CT Images in PET/CT Scans Open

Samaneh Mostafapour, Mazarine Van der Galiën, Joyce van Sluis, Adrienne H. Brouwers, Z. Li , et al. · 2024

The use of Ultra-Low-Dose computed tomography (ULD-CT) in PET/CT imaging is gaining attention due to its potential to significantly reduce radiation exposure, which is crucial for patient safety. Accurate organ segmentation is essential fo…

Mixture prior distributions and Bayesian models for robust radionuclide image processing Open

Muyang Zhang, Robert G. Aykroyd, Charalampos Tsoumpas · 2024

The diagnosis of medical conditions and subsequent treatment often involves radionuclide imaging techniques. To refine localisation accuracy and improve diagnostic confidence, compared with the use of a single scanning technique, a combina…

Clinical Performance Comparison of a Long Versus a Short Axial Field-of-View PET/CT Using EARL-Compliant Reconstructions Open

Mostafa Roya, Johannes H. van Snick, Riemer H. J. A. Slart, Walter Noordzij, Gilles N. Stormezand , et al. · 2024

Left ventricular shape index and eccentricity index with ECG-gated Nitrogen-13 ammonia PET/CT in patients with myocardial infarction, ischemia, and normal perfusion Open

Tonantzin Samara Martínez-Lucio, Erick Alexánderson, Isabel Carvajal-Juárez, Ana Karen Mendoza-Ibáñez, Oscar Isaac Mendoza-Ibáñez , et al. · 2024

Shape and eccentricity indices differ in patients with myocardial infarction as compared to patients with ischemia or normal perfusion. This encourage further research in their potential for detecting LV adverse remodeling.

Advances in PET Imaging of Large Vessel Vasculitis: An Update and Future Trends Open

Kornelis S. M. van der Geest, Olivier Gheysens, Lars Christian Gormsen, Andor W.J.M. Glaudemans, Charalampos Tsoumpas , et al. · 2024

Systemic vasculitides are autoimmune diseases characterized by inflammation of blood vessels. They are categorized based on the size of the preferentially affected blood vessels: large-, medium-, and small-vessel vasculitides. The main for…

Can Internal Carotid Arteries Be Used for Noninvasive Quantification of Brain PET Studies? Open

Laura Providência, Chris W.J. van der Weijden, Philipp Mohr, Joyce van Sluis, Johannes H. van Snick , et al. · 2024

Because of the limited axial field of view of conventional PET scanners, the internal carotid arteries are commonly used to obtain an image-derived input function (IDIF) in quantitative brain PET. However, time-activity curves extracted fr…

Does FDG-PET/CT for incidentally found pulmonary lesions lead to a cascade of more incidental findings? Open

Tim E. Sluijter, Derya Yakar, Christian Roest, Charalampos Tsoumpas, Thomas C. Kwee · 2024

Advances and challenges in immunoPET methodology Open

Philipp Mohr, Joyce van Sluis, Marjolijn N. Lub–de Hooge, Adriaan A. Lammertsma, Adrienne H. Brouwers , et al. · 2024

Immuno-positron emission tomography (immunoPET) enables imaging of specific targets that play a role in targeted therapy and immunotherapy, such as antigens on cell membranes, targets in the disease microenvironment, or immune cells. The m…

Automated multiclass segmentation, quantification, and visualization of the diseased aorta on hybrid PET/CT–SEQUOIA Open

Gijs D. van Praagh, P. H. Nienhuis, Melanie Reijrink, Mirjam E. J. Davidse, Lisa Duff , et al. · 2024

Background Cardiovascular disease is the most common cause of death worldwide, including infection and inflammation related conditions. Multiple studies have demonstrated potential advantages of hybrid positron emission tomography combined…

An assessment of PET and CMR radiomic features for the detection of cardiac sarcoidosis Open

Nouf A. Mushari, Georgios Soultanidis, Lisa Duff, Maria Giovanna Trivieri, Zahi A. Fayad , et al. · 2024

Background Visual interpretation of PET and CMR may fail to identify cardiac sarcoidosis (CS) with high specificity. This study aimed to evaluate the role of [ 18 F]FDG PET and late gadolinium enhancement (LGE)-CMR radiomic features in dif…

Impact of patient motion on parametric PET imaging Open

Alessia Artesani, Joyce van Sluis, Johannes H. van Snick, Laura Providência, Walter Noordzij , et al. · 2024

Beyond stillness: the importance of tackling patient’s motion for reliable parametric imaging Open

Alessia Artesani, Laura Providência, Joyce van Sluis, Charalampos Tsoumpas · 2024

Ultra‐low dose CT scanning for PET/CT Open

Samaneh Mostafapour, Marcel J. W. Greuter, Johannes H. van Snick, Adrienne H. Brouwers, Rudi Dierckx , et al. · 2023

Background The use of computed tomography (CT) for attenuation correction (AC) in whole‐body PET/CT can result in a significant contribution to radiation exposure. This can become a limiting factor for reducing considerably the overall rad…

The first international network symposium on artificial intelligence and informatics in nuclear medicine: “The bright future of nuclear medicine is illuminated by artificial intelligence” Open

Andor W.J.M. Glaudemans, Rudi Dierckx, Bart Scheerder, Wiro J. Niessen, Jan Pruim , et al. · 2023

Current and Future Use of Long Axial Field-of-View Positron Emission Tomography/Computed Tomography Scanners in Clinical Oncology Open

Mostafa Roya, Samaneh Mostafapour, Philipp Mohr, Laura Providência, Z. Li , et al. · 2023

The latest technical development in the field of positron emission tomography/computed tomography (PET/CT) imaging has been the extension of the PET axial field-of-view. As a result of the increased number of detectors, the long axial fiel…

The clinical value of quantitative cardiovascular molecular imaging: a step towards precision medicine Open

Hendrea Tingen, Gijs D. van Praagh, P. H. Nienhuis, Alwin Tubben, Nick D. van Rijsewijk , et al. · 2023

Cardiovascular diseases (CVD) are the leading cause of death worldwide and have an increasing impact on society. Precision medicine, in which optimal care is identified for an individual or a group of individuals rather than for the averag…

[15O]H2O PET: Potential or Essential for Molecular Imaging? Open

Riemer H. J. A. Slart, Tonantzin Samara Martínez-Lucio, Hendrikus H. Boersma, Ronald Borra, Bart Cornelissen , et al. · 2023

Imaging water pathways in the human body provides an excellent way of measuring accurately the blood flow directed to different organs. This makes it a powerful diagnostic tool for a wide range of diseases that are related to perfusion and…

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