Alladi Charanraj Goud
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View article: Cytotoxic and Pro-apoptotic Effects of Curcumin and Vitamin D₃ in a Human Non-Hodgkin’s Lymphoma Cell Line (Daudi): An In Vitro Study
Cytotoxic and Pro-apoptotic Effects of Curcumin and Vitamin D₃ in a Human Non-Hodgkin’s Lymphoma Cell Line (Daudi): An In Vitro Study Open
View article: Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia
Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia Open
Tau aggregation driven by microtubule‐associated protein tau ( MAPT ) mutations is central to frontotemporal dementia pathology, yet no disease‐modifying therapies effectively target mutant tau. Here, we identify purpurin (PUR) and oleocan…
View article: Assessing Autophagy Activation in Advanced Ovarian Cancer Using Ascitic Fluid: A Feasibility Study
Assessing Autophagy Activation in Advanced Ovarian Cancer Using Ascitic Fluid: A Feasibility Study Open
Techniques for analyzing autophagy markers in ascitic fluid were successfully standardized. The ascitic fluid analysis offers a non-invasive, accessible method for studying ovarian cancer biology, potentially enhancing understanding and ma…
View article: Targeting autophagy in platinum-sensitive relapsed ovarian cancer: randomized phase II trial of hydroxychloroquine with chemotherapy with biomarker correlation
Targeting autophagy in platinum-sensitive relapsed ovarian cancer: randomized phase II trial of hydroxychloroquine with chemotherapy with biomarker correlation Open
Adding HCQ to chemotherapy failed to improve response rates or survival in patients with PSROC. Conducting biomarker-stratified clinical trials might show the potential benefit of HCQ. Trial registration number (TRN): The trial was registe…
View article: Ocular Biometry and Genomic Association in Primary Angle Closure Disease. A Descriptive study
Ocular Biometry and Genomic Association in Primary Angle Closure Disease. A Descriptive study Open
Ocular biometric parameters vary significantly in PACD patients compared to normal subjects. Except for corneal curvature, there was no significant difference among PACS, PAC, and PACG.
View article: Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies
Antineoplastics for treating Alzheimer's disease and dementia: Evidence from preclinical and observational studies Open
As the world population ages, there will be an increasing need for effective therapies for aging‐associated neurodegenerative disorders, which remain untreatable. Dementia due to Alzheimer's disease (AD) is one of the leading neurological …
View article: Influence of <i>ABCB1</i> genetic polymorphisms on the antiemetic response to ondansetron-based medication for cisplatin-based chemotherapy in South Indian cancer patients in a tertiary care hospital
Influence of <i>ABCB1</i> genetic polymorphisms on the antiemetic response to ondansetron-based medication for cisplatin-based chemotherapy in South Indian cancer patients in a tertiary care hospital Open
Genetic variations in the receptor, metabolizing enzymes and transporters may explain a part of the variation in anti-emetic response to ondansetron among cancer patients. This study assesses the role of ABCB1 genetic polymorphisms in the …
View article: Impact of Pharmacogenomics in Achieving Personalized/Precision Medicine in the Clinical Setting: A Symposium Report
Impact of Pharmacogenomics in Achieving Personalized/Precision Medicine in the Clinical Setting: A Symposium Report Open
The Indo-Swiss symposium on pharmacogenomic strategies for the implementation of personalized medicine was conducted as part of the Jawaharlal Institute of Postgraduate Medical Education and Research Integrated Pharmacogenomics Program in …
View article: Influence of Vitamin D Status and IL-10 Gene Promoter Polymorphism (rs1800871) on Plasma IL-10 Levels in Apparently Healthy Individuals from Southern India: A Cross-sectional Study
Influence of Vitamin D Status and IL-10 Gene Promoter Polymorphism (rs1800871) on Plasma IL-10 Levels in Apparently Healthy Individuals from Southern India: A Cross-sectional Study Open
Introduction: Interleukin-10 (IL-10) is a major anti-inflammatory cytokine, which plays an important role in regulating inflammatory responses of the immune system. Changes in IL-10 level and its function can cause an imbalance in immune r…
View article: Risperidone Response in Patients with Schizophrenia Drives DNA Methylation Changes in Immune and Neuronal Systems
Risperidone Response in Patients with Schizophrenia Drives DNA Methylation Changes in Immune and Neuronal Systems Open
Background: The choice of efficient antipsychotic therapy for schizophrenia relies on a time-consuming trial-and-error approach, whereas the social and economic burdens of the disease call for faster alternatives. Material & meth…
View article: Association between metabolic syndrome components and cardiac autonomic modulation in southern Indian adults with pre-metabolic syndrome: hyperglycemia is the major contributing factor
Association between metabolic syndrome components and cardiac autonomic modulation in southern Indian adults with pre-metabolic syndrome: hyperglycemia is the major contributing factor Open
Metabolic syndrome (MetS) involves multi-factorial conditions linked to an elevated risk of type 2 diabetes mellitus and cardiovascular disease. Pre-metabolic syndrome (pre-MetS) possesses two MetS components but does not meet the MetS dia…
View article: Matrixmetalloproteinase-9 gene polymorphism (rs 17576) increases the risk of depressive symptoms in bipolar disorder
Matrixmetalloproteinase-9 gene polymorphism (rs 17576) increases the risk of depressive symptoms in bipolar disorder Open
Objectives: Plasticity of neural synapses is known to be involved in the complications in bipolar disorder (BD) patients. Matrix metalloproteinases (MMPs) play a role in synaptic plasticity and memory. Even though elevated MMP-9 levels are…
View article: Risperidone Reduces Matrix Metalloproteinase-9 and Increases Neurotrophin-3 in Schizophrenia Spectrum of Disorder
Risperidone Reduces Matrix Metalloproteinase-9 and Increases Neurotrophin-3 in Schizophrenia Spectrum of Disorder Open
View article: Dopamine (<i><scp>DRD</scp>2</i>) and Serotonin (<i><scp>HTR</scp>2A, 2C)</i> Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia
Dopamine (<i><span>DRD</span>2</i>) and Serotonin (<i><span>HTR</span>2A, 2C)</i> Receptor Gene Polymorphisms do not influence early response to Risperidone in South Indian Patients with Schizophrenia Open
Treatment response to antipsychotic drugs is variable and conflicting results have been obtained while studying the influence of DRD 2 and HTR 2 genetic variants on antipsychotic drug efficacy. To explore further, the present study aimed t…
View article: DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder
DNA Methylation as a Biomarker of Treatment Response Variability in Serious Mental Illnesses: A Systematic Review Focused on Bipolar Disorder, Schizophrenia, and Major Depressive Disorder Open
So far, genetic studies of treatment response in schizophrenia, bipolar disorder, and major depression have returned results with limited clinical utility. A gene × environment interplay has been proposed as a factor influencing not only p…
View article: Risperidone-Induced Adverse Drug Reactions and Role of DRD2 (−141 C Ins/Del) and 5HTR2C (−759 C>T) Genetic Polymorphisms in Patients with Schizophrenia
Risperidone-Induced Adverse Drug Reactions and Role of DRD2 (−141 C Ins/Del) and 5HTR2C (−759 C>T) Genetic Polymorphisms in Patients with Schizophrenia Open
Hyperprolactinemia, weight gain, and EPSs (>36.7%) were common adverse effects of risperidone. DRD2 - 141C Ins/Del and Del/Del polymorphisms were significantly associated with increased prolactin levels (OR = 10.45) in response to r…