Shaneen Singh
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View article: A Genome-Wide Modeling and Characterization Study of Pleckstrin Homology Domains in Chlamydomonas reinhardtii
A Genome-Wide Modeling and Characterization Study of Pleckstrin Homology Domains in Chlamydomonas reinhardtii Open
The function of pleckstrin homology (PH) domains is to recognize and bind to specific phosphoinositides in the membranes as part of diverse cellular signaling processes. The structure of some PH domains has been solved by X-ray crystallogr…
View article: Integrating Global Perspective Skills in Holistic Accounting Education: A Quantitative Analysis of Chinese Undergraduate Programs
Integrating Global Perspective Skills in Holistic Accounting Education: A Quantitative Analysis of Chinese Undergraduate Programs Open
This study examines the integration of global perspective skills in holistic accounting education within Chinese undergraduate programs, emphasizing the impact of case-based learning on students’ preparedness for international accounting c…
View article: In silico analysis of human NEK10 reveals novel domain architecture and protein-protein interactions
In silico analysis of human NEK10 reveals novel domain architecture and protein-protein interactions Open
View article: Abstract 1223 Sevoflurane disrupts the REDD1/14-3-3 Interaction and BNIP3/Rheb Binding to Allow for Continued mTOR pathway activation, Neuronal Hyperpolarization, and Cellular Protection during Periods of Hypoxia
Abstract 1223 Sevoflurane disrupts the REDD1/14-3-3 Interaction and BNIP3/Rheb Binding to Allow for Continued mTOR pathway activation, Neuronal Hyperpolarization, and Cellular Protection during Periods of Hypoxia Open
View article: Venomous Cargo: Diverse Toxin-Related Proteins Are Associated with Extracellular Vesicles in Parasitoid Wasp Venom
Venomous Cargo: Diverse Toxin-Related Proteins Are Associated with Extracellular Vesicles in Parasitoid Wasp Venom Open
Unusual membrane-bound particles are present in the venom of the parasitoid wasps that parasitize Drosophila melanogaster. These venom particles harbor about 400 proteins and suppress the encapsulation of a wasp egg. Whereas the proteins i…
View article: Integrating Global Perspective Skills in Holistic Accounting Education: A Quantitative Analysis of Chinese Undergraduate Programs
Integrating Global Perspective Skills in Holistic Accounting Education: A Quantitative Analysis of Chinese Undergraduate Programs Open
This study examines the integration of global perspective skills in holistic accounting education within Chinese undergraduate programs, emphasizing the impact of case-based learning on students’ preparedness for international accounting c…
View article: An In Silico Investigation of Human NEK10 Reveals Novel Domain Architecture and Protein-Protein Interactions
An In Silico Investigation of Human NEK10 Reveals Novel Domain Architecture and Protein-Protein Interactions Open
Cancer is the second leading cause of death worldwide, with 27.5 million new cases projected by 2040. Disruptions in cell cycle control cause DNA errors to accumulate during cell growth, mak-ing proteins that regulate cell cycle progressio…
View article: NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons
NEKL-4 regulates microtubule stability and mitochondrial health in ciliated neurons Open
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-o…
View article: Abstract 1402 Rac1/Rab5-Mediated Suppression of Armus Facilitates the Rab7-Mediated Secretory Lysosomal and Transcytotic Pathways in the Osteoclast
Abstract 1402 Rac1/Rab5-Mediated Suppression of Armus Facilitates the Rab7-Mediated Secretory Lysosomal and Transcytotic Pathways in the Osteoclast Open
In normal human bone remodeling, osteoclastic bone resorption is a highly coordinated and multi-pronged process, under the indirect hormonal control of parathyroid hormone. Once stimulated, several mechanisms must work in-concert to drive …
View article: NEKL-4 regulates microtubule stability and mitochondrial health in<i>C. elegans</i>ciliated neurons
NEKL-4 regulates microtubule stability and mitochondrial health in<i>C. elegans</i>ciliated neurons Open
Ciliopathies are often caused by defects in the ciliary microtubule core. Glutamylation is abundant in cilia, and its dysregulation may contribute to ciliopathies and neurodegeneration. Mutation of the deglutamylase CCP1 causes infantile-o…
View article: Impact of Ekadhiken Purven Sutra on Students at Kasturba Gandhi Girls Hostel, Bazpur(Uttarakhand): An Analysis
Impact of Ekadhiken Purven Sutra on Students at Kasturba Gandhi Girls Hostel, Bazpur(Uttarakhand): An Analysis Open
In this case study, we developed the impact of the "Ekadhiken Purven Sutra" from Vedic Mathematics on students at the Kasturba Gandhi Girls Hostel. This sutra is renowned for simplifying the squaring of numbers ending in 5 and improving me…
View article: In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation–Polar–Cation Clip Motif in Knottin Proteins
In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation–Polar–Cation Clip Motif in Knottin Proteins Open
As generalist parasitoid wasps, Leptopilina heterotoma are highly successful on many species of fruit flies of the genus Drosophila. The parasitoids produce specialized multi-strategy extracellular vesicle (EV)-like structures in their ven…
View article: A combined <i>in silico</i> and <i>in vivo</i> approach to the structure-function annotation of SPD-2 provides mechanistic insight into its functional diversity
A combined <i>in silico</i> and <i>in vivo</i> approach to the structure-function annotation of SPD-2 provides mechanistic insight into its functional diversity Open
Centrosomes are organelles that function as hubs of microtubule nucleation and organization, with key roles in organelle positioning, asymmetric cell division, ciliogenesis, and signaling. Aberrant centrosome number, structure or function …
View article: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae. Open
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phosp…
View article: Author response: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
Author response: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae Open
View article: In silico study predicts a key role of RNA-binding domains 3 and 4 in nucleolin-miRNA interactions.
In silico study predicts a key role of RNA-binding domains 3 and 4 in nucleolin-miRNA interactions. Open
RNA binding proteins (RBPs) regulate many important cellular processes through their interactions with RNA molecules. RBPs are critical for post-transcriptional mechanisms keeping gene regulation in a fine equilibrium. Conversely, dysregul…
View article: Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14 and Sic1 for origin licensing in <i>S. cerevisiae</i>
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14 and Sic1 for origin licensing in <i>S. cerevisiae</i> Open
Cdc6, a subunit of the pre-replicative complex, contains multiple regulatory Cdk1 consensus sites, SP or TP motifs. In S. cerevisiae , Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S-phase, for subsequent multisi…
View article: <i>In silico</i>study predicts a key role of RNA-binding domains 3 and 4 in nucleolin-miRNA interactions
<i>In silico</i>study predicts a key role of RNA-binding domains 3 and 4 in nucleolin-miRNA interactions Open
RNA binding proteins (RBPs) regulate many important cellular processes through their interactions with RNA molecules. RBPs are critical for post-transcriptional mechanisms keeping gene regulation in a fine equilibrium. Conversely, dysregul…
View article: The Centrosomal Swiss Army Knife: A combined in silico and in vivo approach to the structure-function annotation of SPD-2 provides mechanistic insight into its functional diversity
The Centrosomal Swiss Army Knife: A combined in silico and in vivo approach to the structure-function annotation of SPD-2 provides mechanistic insight into its functional diversity Open
Centrosomes are organelles that function as hubs of microtubule nucleation and organization, with key roles in organelle positioning, asymmetric cell division, and ciliogenesis. Aberrant centrosome structure or function is linked to neurod…
View article: Biol 4010W/7190G/CISC2810W: Macromolecular structure and bioinformatics
Biol 4010W/7190G/CISC2810W: Macromolecular structure and bioinformatics Open
View article: Insights into the mechanism of recruitment of different membrane-binding domains of Arabidopsis thaliana using computational approaches.
Insights into the mechanism of recruitment of different membrane-binding domains of Arabidopsis thaliana using computational approaches. Open
View article: Inhibition of ricin A-chain (RTA) catalytic activity by a viral genome-linked protein (VPg)
Inhibition of ricin A-chain (RTA) catalytic activity by a viral genome-linked protein (VPg) Open
View article: A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster
A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster Open
This study reports on a putative eicosanoid biosynthesis pathway in Drosophila melanogaster and challenges the currently held view that mechanistic routes to synthesize eicosanoid or eicosanoid-like biolipids do not exist in insects, since…
View article: Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila
Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila Open
View article: Academic Motivation Among Urban & Rural Students:
A Study On Traditional Vs Open Education System In India
Academic Motivation Among Urban & Rural Students:
A Study On Traditional Vs Open Education System In India Open
Higher education today is being viewed as a tool to achieve prosperity and high living standards. It is thus looked upon as a service to the society and a powerful weapon to change the society for its betterment. Motivation plays a crucial…