Charlene Compher
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View article: Association between protein dose in the early and late acute phases of critical illness and time‐to‐discharge‐alive: A secondary analysis of a randomized clinical trial
Association between protein dose in the early and late acute phases of critical illness and time‐to‐discharge‐alive: A secondary analysis of a randomized clinical trial Open
Background Research has sought to identify optimal protein doses during acute phases of critical illness to optimize outcomes. Methods A secondary analysis of the EFFORT Protein trial, which compared high vs usual protein ( N = 1301). Only…
View article: Methodological standards for body composition—an expert-endorsed guide for research and clinical applications: levels, models, and terminology
Methodological standards for body composition—an expert-endorsed guide for research and clinical applications: levels, models, and terminology Open
Body composition assessment is widely used in both research and clinical practice, yet confusion over basic concepts and terminology persists, leading to inaccurate assessments, comparisons, and interpretations. To address this concern, an…
View article: GLIM consensus approach to diagnosis of malnutrition: A 5‐year update
GLIM consensus approach to diagnosis of malnutrition: A 5‐year update Open
Background The Global Leadership Initiative on Malnutrition (GLIM) introduced an approach for malnutrition diagnosis in 2019 that comprised screening followed by assessment of three phenotypic criteria (weight loss, low body mass index [BM…
View article: Sex-based differences in imaging-derived body composition and their association with clinical malnutrition in abdominal surgery patients
Sex-based differences in imaging-derived body composition and their association with clinical malnutrition in abdominal surgery patients Open
Structured Abstract Background Malnutrition significantly impacts surgical outcomes yet is difficult to identify preoperatively. Few studies have investigated the association between comprehensive body composition assessment and malnutriti…
View article: The GLIM consensus approach to diagnosis of malnutrition: A 5-year update
The GLIM consensus approach to diagnosis of malnutrition: A 5-year update Open
View article: Role of dietitians in optimizing medical nutrition therapy in cardiac surgery patients: A secondary analysis of an international multicenter observational study
Role of dietitians in optimizing medical nutrition therapy in cardiac surgery patients: A secondary analysis of an international multicenter observational study Open
Background Better understanding the impact of dietetic services on nutrition practices seems required as it may represent an opportunity for optimization in post–cardiac surgery patients. The present study aims to evaluate and compare nutr…
View article: Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition
Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition Open
CONCLUSION: Research using consistent etiologic and phenotypic variables offers great potential to assess the efficacy of nutrition interventions for critically ill patients with malnutrition. Assessment of these variables at during and be…
View article: Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition
Recognizing malnutrition in adults with critical illness: Guidance statements from the Global Leadership Initiative on Malnutrition Open
Background Patients with critical illness may present with disease‐related malnutrition upon intensive care unit (ICU) admission. They are at risk of development and progression of malnutrition over the disease trajectory because of inflam…
View article: The nutritional impact of 7 versus 21 home-delivered medically tailored meals in patients with heart failure and malnutrition risk: a random order crossover feeding trial (MEDIMEALS)
The nutritional impact of 7 versus 21 home-delivered medically tailored meals in patients with heart failure and malnutrition risk: a random order crossover feeding trial (MEDIMEALS) Open
View article: The ASPEN Rhoads Research Foundation: Supporting and advancing clinical nutrition research
The ASPEN Rhoads Research Foundation: Supporting and advancing clinical nutrition research Open
The vision of the ASPEN Rhoads Research Foundation is to promote innovation and research discovery to improve nutrition care and health. The Foundation was launched in 1993, incorporated in 2002, and established as a nonprofit 501(c)(3) or…
View article: The comparative effectiveness of 7 versus 21 home-delivered Medically Tailored Meals to improve malnutrition risk in malnourished patients with heart failure: A random order crossover feeding trial (MEDIMEALS)
The comparative effectiveness of 7 versus 21 home-delivered Medically Tailored Meals to improve malnutrition risk in malnourished patients with heart failure: A random order crossover feeding trial (MEDIMEALS) Open
Background: Heart failure (HF) is frequently associated with risk of malnutrition or frank malnutrition. The delivery of medically tailored meals (MTM) to the homes of patients with HF and malnutrition risk or a malnutrition diagnosis afte…
View article: Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial
Plasma metabolomics changes comparing daytime to overnight infusions of home parenteral nutrition in adult patients with short bowel syndrome: Secondary analysis of a clinical trial Open
View article: A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease
A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease Open
Background & Aims: This study compared the effectiveness of the Specific Carbohydrate Diet (SCD) to the Mediterranean diet (MD) as treatment for Crohn's disease (CD) with mild to moderate symptoms. Methods: Adult patients with CD and with …
View article: Healthy Sleep Practices for Consumers of Home Total Parenteral Nutrition: A Mixed-Methods Community-Based Participatory Study
Healthy Sleep Practices for Consumers of Home Total Parenteral Nutrition: A Mixed-Methods Community-Based Participatory Study Open
The curated healthy sleep resource tailored for HPN consumers was facilitated by a multidisciplinary expert panel, a strategic collaboration with members of the HPN community and their clinicians, and in partnership with patient advocacy a…
View article: THE MODULATORY EFFECT OF PREBIOTIC INULIN-TYPE FRUCTANS ON THE MICROBIOME PROFILE OF CHILDREN WITH INFLAMMATORY BOWEL DISEASE: A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL
THE MODULATORY EFFECT OF PREBIOTIC INULIN-TYPE FRUCTANS ON THE MICROBIOME PROFILE OF CHILDREN WITH INFLAMMATORY BOWEL DISEASE: A DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL Open
OBJECTIVE The intestinal microbiota plays a pivotal role in the inflammation associated with inflammatory bowel disease (IBD) through their interaction with the mucosal immune system. Prebiotic interventions using inulin-type fructans incr…
View article: Guidance for assessment of the inflammation etiologic criterion for the GLIM diagnosis of malnutrition: A modified Delphi approach
Guidance for assessment of the inflammation etiologic criterion for the GLIM diagnosis of malnutrition: A modified Delphi approach Open
Background The Global Leadership Initiative on Malnutrition (GLIM) approach to malnutrition diagnosis is based on assessment of three phenotypic (weight loss, low body mass index, and reduced skeletal muscle mass) and two etiologic (reduce…
View article: Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts
Surgery for Crohn’s Disease Is Associated With a Dysbiotic Microbiome and Metabolome: Results From Two Prospective Cohorts Open
In 2 different populations, prior surgery in Crohn's disease is associated with altered fecal microbiome. Patients who had undergone ileal resection had reduction in the potentially beneficial bacteria E lenta and related actinobacteria an…
View article: Glycemic and sleep effects of daytime compared with those of overnight infusions of home parenteral nutrition in adults with short bowel syndrome: A quasi-experimental pilot trial
Glycemic and sleep effects of daytime compared with those of overnight infusions of home parenteral nutrition in adults with short bowel syndrome: A quasi-experimental pilot trial Open
View article: An Integrative Bioinformatics Pipeline for NHANES Data Processing for Machine Learning Analysis of Oral Health Outcomes
An Integrative Bioinformatics Pipeline for NHANES Data Processing for Machine Learning Analysis of Oral Health Outcomes Open
Large database sources, such as the National Health and Nutrition Examination Survey (NHANES), while being a great utility for epidemiological studies, pose challenges for machine learning due to data heterogeneity, varied sample sizes, mi…
View article: Guidance for assessment of the inflammation etiologic criterion for the GLIM diagnosis of malnutrition: A modified Delphi approach
Guidance for assessment of the inflammation etiologic criterion for the GLIM diagnosis of malnutrition: A modified Delphi approach Open
View article: Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption
Human Intestinal Microbiome Determines Individualized Inflammatory Response to Dietary Emulsifier Carboxymethylcellulose Consumption Open
International audience
View article: Poor quality, pro-inflammatory diet in children with Crohn’s disease and healthy controls: a cross-sectional study
Poor quality, pro-inflammatory diet in children with Crohn’s disease and healthy controls: a cross-sectional study Open
Background: Diet plays a critical role in development and progression of Crohn’s disease (CD). Dietary indices are important tools to evaluate diet quality and dietary inflammatory potential, and we investigated the associations of it with…
View article: Penn Healthy Diet survey: pilot validation and scoring
Penn Healthy Diet survey: pilot validation and scoring Open
Though diet quality is widely recognised as linked to risk of chronic disease, health systems have been challenged to find a user-friendly, efficient way to obtain information about diet. The Penn Healthy Diet (PHD) survey was designed to …
View article: AB1156 METABOLIC DISORDERS AND ABNORMAL DIETARY PATTERNS AND THEIR ASSOCIATION WITH PSORIATIC ARTHRITIS ACTIVITY: THE DIETARY INTERVENTION IN PSA (DIPSA) STUDY
AB1156 METABOLIC DISORDERS AND ABNORMAL DIETARY PATTERNS AND THEIR ASSOCIATION WITH PSORIATIC ARTHRITIS ACTIVITY: THE DIETARY INTERVENTION IN PSA (DIPSA) STUDY Open
Background Psoriatic Arthritis (PsA) is associated with obesity and its related metabolic abnormalities. The role of diet as an adjunct therapy in PsA remains unclear. Objectives We aimed to describe the prevalence of cardiometabolic abnor…
View article: A diet modification intervention for older women with fecal incontinence
A diet modification intervention for older women with fecal incontinence Open
The authors declare no conflicts of interest. Data S1: Booklet 1: "Dietary Management for ABL," Booklet 2: "Ways to Naturally Increase Dietary Fiber," and "My Food and Bowel Journal." Please note: The publisher is not responsible for the c…
View article: Current practices in nutrition therapy in cardiac surgery patients: An international multicenter observational study
Current practices in nutrition therapy in cardiac surgery patients: An international multicenter observational study Open
Background Cardiac surgery patients with a prolonged stay in the intensive care unit (ICU) are at high risk for acquired malnutrition. Medical nutrition therapy practices for cardiac surgery patients are unknown. The objective of this stud…
View article: Associations between dietary intake, diet quality and depressive symptoms in youth: A systematic review of observational studies
Associations between dietary intake, diet quality and depressive symptoms in youth: A systematic review of observational studies Open
Background: Depression is the third leading cause of worldwide disease burden among youth, and nutrition- and diet-related behaviors have been considered as an effective strategy for reducing the risk of depressive symptoms. This systemati…
View article: Diet standardization reduces intra-individual microbiome variation
Diet standardization reduces intra-individual microbiome variation Open
The human gut microbiota is highly heterogenous between individuals and also exhibits considerable day-to-day variation within individuals. We hypothesized that diet contributed to such inter- and/or intra-individual variance. Hence, we in…
View article: Development of the Penn Healthy Diet screener with reference to adult dietary intake data from the National Health and Nutrition Examination Survey
Development of the Penn Healthy Diet screener with reference to adult dietary intake data from the National Health and Nutrition Examination Survey Open
Background There is a need for a feasible, user-friendly tool that can be employed to assess the overall quality of the diet in U.S. clinical settings. Our objectives were to develop the Penn Healthy Diet (PHD) screener, evaluate screener …
View article: Infusion timing and sleep habits of adults receiving home parenteral and enteral nutrition: A patient‐oriented survey study
Infusion timing and sleep habits of adults receiving home parenteral and enteral nutrition: A patient‐oriented survey study Open
Background The emerging field of chrononutrition investigates the effects of the timing of nutritional intake on human physiology and disease pathology. It remains largely unknown when patients receiving home nutrition support routinely ad…