Charles ffrench‐Constant
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View article: snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses Open
Poor understanding of the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies. To address this gap, we analyzed 632,000 single-nucleu…
View article: Electroconvulsive stimuli reverse neuro-inflammation and behavioral deficits in a mouse model of depression
Electroconvulsive stimuli reverse neuro-inflammation and behavioral deficits in a mouse model of depression Open
Background Electroconvulsive therapy is a fast, safe, and effective treatment for severe clinical depression but there is an ongoing search for mechanistic insights. Methods We used a mouse neuro-endocrine model of depression to examine be…
View article: Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glial responses
Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glial responses Open
The lack of understanding of the cellular and molecular basis of clinical and genetic heterogeneity in progressive multiple sclerosis (MS) has hindered the search for new effective therapies. Here, to address this gap, we analysed 632,000 …
View article: Connexin 43-mediated Neurovascular Interactions Regulate Neurogenesis in the Adult Brain Subventricular Zone
Connexin 43-mediated Neurovascular Interactions Regulate Neurogenesis in the Adult Brain Subventricular Zone Open
The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct interactions between NSCs and endothelial cells (ECs). Mechanisms by which direct NSC-E…
View article: Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis
Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis Open
Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) result in Allan-Herndon-Dudley Syndrome, a severe form of psychomotor retardation, while inactivating mutations in another TH transporter, …
View article: iPSC-derived myelinoids to study myelin biology of humans
iPSC-derived myelinoids to study myelin biology of humans Open
(Developmental Cell 56, 1346–1358.e1–e6; May 3, 2021) In the originally published version of this article, in the “Generation of iPSC myelinoids” paragraph of the STAR Methods section, the authors inadvertently included typographical error…
View article: Combinatorial ECM Arrays Identify Cooperative Roles for Matricellular Proteins in Enhancing the Generation of TH+ Neurons From Human Pluripotent Cells
Combinatorial ECM Arrays Identify Cooperative Roles for Matricellular Proteins in Enhancing the Generation of TH+ Neurons From Human Pluripotent Cells Open
The development of efficient cell culture strategies for the generation of dopaminergic neurons is an important goal for transplantation-based approaches to treat Parkinson’s disease. To identify extracellular matrix molecules that enhance…
View article: Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length
Oligodendrocyte HCN2 Channels Regulate Myelin Sheath Length Open
Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the CNS. Myelin sheath length is a key property that determines axonal conduction velocity and is known to be variable across the CNS. Myelin sheath …
View article: Establishing an Adult Mouse Brain Hippocampal Organotypic Slice Culture System that Allows for Tracing and Pharmacological Manipulation of ex vivo Neurogenesis
Establishing an Adult Mouse Brain Hippocampal Organotypic Slice Culture System that Allows for Tracing and Pharmacological Manipulation of ex vivo Neurogenesis Open
The function of the hippocampus depends on the process of adult hippocampal neurogenesis which underpins the exceptional neural plasticity of this structure, and is also frequently affected in CNS pathologies. Thus, manipulation of this pr…
View article: The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2
The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2 Open
During axonal ensheathment, noncompact myelin channels formed at lateral edges of the myelinating process become arranged into tight paranodal spirals that resemble loops when cut in cross section. These adhere to the axon, concentrating v…
View article: Staining and Quantitative Analysis of Myelinating Oligodendrocytes in the Mouse Grey Matter
Staining and Quantitative Analysis of Myelinating Oligodendrocytes in the Mouse Grey Matter Open
Oligodendrocytes generate distinct patterns of myelination throughout the CNS. Variations in myelination along axons may enable neurons to fine-tune conduction velocities and alter signal synchronisation. Here we outline a staining protoco…
View article: Endothelin signalling mediates experience-dependent myelination in the CNS
Endothelin signalling mediates experience-dependent myelination in the CNS Open
Experience and changes in neuronal activity can alter CNS myelination, but the signalling pathways responsible remain poorly understood. Here we define a pathway in which endothelin, signalling through the G protein-coupled receptor endoth…
View article: PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS
PI 3-kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS Open
Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regenera…
View article: Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte–myelin dysfunction
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte–myelin dysfunction Open
Although the underlying neurobiology of major mental illness (MMI) remains unknown, emerging evidence implicates a role for oligodendrocyte-myelin abnormalities. Here, we took advantage of a large family carrying a balanced t(1;11) translo…
View article: Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction Open
Although the underlying neurobiology of major mental illness (MMI) remains unknown, emerging evidence implicates a role for oligodendrocyte-myelin abnormalities. Here, we took advantage of a large family carrying a balanced t(1;11) translo…
View article: Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development
Laminin α2 controls mouse and human stem cell behaviour during midbrain dopaminergic neuron development Open
The development of the central nervous system requires the coordination of proliferation and differentiation of neural stem cells. Here, we show that laminin alpha 2 (lm-α2) is a component of the midbrain dopaminergic (mDA) progenitor nich…
View article: Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination
Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination Open
The loss of oligodendrocytes (OLs) and subsequently myelin sheaths following injuries or pathologies in the CNS leads to debilitating functional deficits. Unfortunately, effective methods of remyelination remain limited. Here, we present a…