Charles H. Cook
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View article: Cytomegalovirus-induced oncomodulation drives immune escape in glioblastoma
Cytomegalovirus-induced oncomodulation drives immune escape in glioblastoma Open
Immune evasion and suppression lead to unchecked tumor growth in glioblastoma. Cytomegalovirus (CMV) has been implicated in tumor progression and modulation in glioblastoma. To investigate this potential connection, CMV-associated changes …
View article: Clinical implications of cytomegalovirus in glioblastoma progression and therapy
Clinical implications of cytomegalovirus in glioblastoma progression and therapy Open
Glioblastoma (GBM) is one of the deadliest brain cancers with a median survival of only 15 months. This poor prognosis has prompted exploration of novel therapeutic targets for GBM patients. Human cytomegalovirus (HCMV) has been implicated…
View article: Cytomegalovirus durably primes neutrophil oxidative burst
Cytomegalovirus durably primes neutrophil oxidative burst Open
Cytomegalovirus (CMV) is a ubiquitous herpes virus that infects most humans, thereafter persisting lifelong in tissues of the host. It is a known pathogen in immunosuppressed patients, but its impact on immunocompetent hosts remains less u…
View article: Quantifying the Prognostic Value of Preoperative Surgeon Intuition: Comparing Surgeon Intuition and Clinical Risk Prediction as Derived from the American College of Surgeons NSQIP Risk Calculator
Quantifying the Prognostic Value of Preoperative Surgeon Intuition: Comparing Surgeon Intuition and Clinical Risk Prediction as Derived from the American College of Surgeons NSQIP Risk Calculator Open
BACKGROUND: Surgical risk prediction models traditionally use patient attributes and measures of physiology to generate predictions about postoperative outcomes. However, the surgeon’s assessment of the patient may be a valuable predictor,…
View article: CSIG-19. CYTOMEGALOVIRUS INFECTION LEADS TO NF-kB DEPENDENT UPREGULATION OF c-MET AND MGMT IN GLIOBLASTOMA AND RESISTANCE TO TEMOZOLOMIDE IN VIVO
CSIG-19. CYTOMEGALOVIRUS INFECTION LEADS TO NF-kB DEPENDENT UPREGULATION OF c-MET AND MGMT IN GLIOBLASTOMA AND RESISTANCE TO TEMOZOLOMIDE IN VIVO Open
INTRODUCTION Cytomegalovirus (CMV), a member of the betaherpesvirinae subfamily widespread in human populations has been reported to be detectable in glioblastoma (GBM). We have recently shown that CMV latent infection promotes GBM growth …
View article: Cytomegalovirus reactivation: Another reason to minimize graft ischemia/reperfusion
Cytomegalovirus reactivation: Another reason to minimize graft ischemia/reperfusion Open
The author comments on the importance of Zhang et al’s (page 2421) observation that ischemia and reperfusion can trigger CMV reactivation after solid organ transplantation. The author comments on the importance of Zhang et al’s (page 2421)…
View article: Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis
Cytomegalovirus promotes murine glioblastoma growth via pericyte recruitment and angiogenesis Open
Cytomegalovirus (CMV) has been implicated in glioblastoma (GBM); however, a mechanistic connection in vivo has not been established. The purpose of this study is to characterize the effects of murine CMV (MCMV) on GBM growth in murine mode…
View article: TMOD-26. CYTOMEGALOVIRUS PROMOTES GLIOBLASTOMA GROWTH VIA PDGF-D DRIVEN PERICYTE RECRUITMENT AND ANGIOGENESIS
TMOD-26. CYTOMEGALOVIRUS PROMOTES GLIOBLASTOMA GROWTH VIA PDGF-D DRIVEN PERICYTE RECRUITMENT AND ANGIOGENESIS Open
Human cytomegalovirus (HCMV) is highly prevalent, and like other herpes viruses, can persist for life in its host in a latent state. However, HCMV can be severely pathogenic in immunocompromised individuals. Interestingly, HCMV proteins an…
View article: Antiviral prophylaxis of cytomegalovirus reactivation in immune competent patients—the jury remains out
Antiviral prophylaxis of cytomegalovirus reactivation in immune competent patients—the jury remains out Open
Cytomegalovirus (CMV) has been recognized as a pathogen in immunosuppressed patients for many years, with viral reactivation after transplantation continuing to plague many patients.
View article: Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections
Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections Open
We were able to identify patients at high risk for treatment failure in the STOP-IT trial. Such patients did not benefit from a longer course of antibiotic administration. Further study is needed to determine the optimum duration of antimi…
View article: Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections
Novel Method Suggests Global Superiority of Short-Duration Antibiotics for Intra-abdominal Infections Open
Desirability of outcome ranking and response adjusted for duration of antibiotic risk (DOOR/RADAR) are novel and innovative methods of evaluating data in antibiotic trials. We analyzed data from a noninferiority trial of short-course antim…
View article: P08.30 CMV infection influences paracrine interactions in the glioblastoma microenvironment and amplifies the angiogenic phenotype.
P08.30 CMV infection influences paracrine interactions in the glioblastoma microenvironment and amplifies the angiogenic phenotype. Open
\nObjective: Cytomegalovirus (CMV) is a ubiquitous member of the herpes virus family with a prevalence of between 50-100% in the human population and lifelong persistence. While usually clinically benign, severe cases are observed in neona…
View article: Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation
Cytomegalovirus Reinfections Stimulate CD8 T-Memory Inflation Open
Cytomegalovirus (CMV) has been shown to induce large populations of CD8 T-effector memory cells that unlike central memory persist in large quantities following infection, a phenomenon commonly termed "memory inflation". Although murine mo…
View article: Obesity Is Not Associated with Antimicrobial Treatment Failure for Intra-Abdominal Infection
Obesity Is Not Associated with Antimicrobial Treatment Failure for Intra-Abdominal Infection Open
Background: Obesity and commonly associated comorbidities are known risk factors for the development of infections. However, the intensity and duration of antimicrobial treatment are rarely conditioned on body mass index (BMI). In particul…
View article: Broncholaveolar lavage to detect cytomegalovirus infection, latency, and reactivation in immune competent hosts
Broncholaveolar lavage to detect cytomegalovirus infection, latency, and reactivation in immune competent hosts Open
Roughly 1/3rd of immune competent patients will reactivate latent cytomegalovirus (CMV) during critical illness. There are no standard methods to detect reactivation, and some investigators have postulated that presence of DNA in BAL fluid…
View article: Predictors of dexmedetomidine-associated hypotension in critically ill patients
Predictors of dexmedetomidine-associated hypotension in critically ill patients Open
Dexmedetomidine-associated hypotension is common. Preexisting low blood pressure, history of coronary artery disease, and higher acuity were identified as independent risk factors for dexmedetomidine-associated hypotension.
View article: Extremes of shock index predicts death in trauma patients
Extremes of shock index predicts death in trauma patients Open
Our data indicate a bimodal relationship between SI and mortality in head injured patients that persists after correction for various co-factors. The distribution of mortality is different between head injured patients and patients without…
View article: Do Polymicrobial Intra-Abdominal Infections Have Worse Outcomes than Monomicrobial Intra-Abdominal Infections?
Do Polymicrobial Intra-Abdominal Infections Have Worse Outcomes than Monomicrobial Intra-Abdominal Infections? Open
Contrary to our hypothesis, polymicrobial IAI do not have worse outcomes than monomicrobial infections. These results suggest polymicrobial IAI can be treated the same as monomicrobial IAI.
View article: WSES guidelines for management of Clostridium difficile infection in surgical patients
WSES guidelines for management of Clostridium difficile infection in surgical patients Open
In the last two decades there have been dramatic changes in the epidemiology of Clostridium difficile infection (CDI), with increases in incidence and severity of disease in many countries worldwide. The incidence of CDI has also increased…
View article: Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection
Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection Open
In patients with intraabdominal infections who had undergone an adequate source-control procedure, the outcomes after fixed-duration antibiotic therapy (approximately 4 days) were similar to those after a longer course of antibiotics (appr…