Charles D. Blaha
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View article: Toward an in Vivo Understanding of Addiction and Neuromodulation: Electrophysiologic Correlates of Neurochemicals During Opioid Administration in a Swine Model of Tractography-Guided Deep Brain Stimulation
Toward an in Vivo Understanding of Addiction and Neuromodulation: Electrophysiologic Correlates of Neurochemicals During Opioid Administration in a Swine Model of Tractography-Guided Deep Brain Stimulation Open
Introduction: Dysregulation of mesolimbic dopamine pathways contributes to the pathophysiology of opioid addiction. Although intraoperative electrophysiology is routinely performed during deep brain stimulation (DBS), no existing clinical …
View article: Application of a human stereotactic system for image-guided deep brain stimulation neurosurgery in a swine model
Application of a human stereotactic system for image-guided deep brain stimulation neurosurgery in a swine model Open
View article: High-Frequency Stimulation of the Ventral Tegmental Area Rescues Respiratory Failure
High-Frequency Stimulation of the Ventral Tegmental Area Rescues Respiratory Failure Open
View article: A Multimodal Platform for Real-Time Neurochemical and Electrophysiologic Monitoring for Intraoperative Neurosurgical Applications
A Multimodal Platform for Real-Time Neurochemical and Electrophysiologic Monitoring for Intraoperative Neurosurgical Applications Open
View article: Expansion of stereotactic work envelope using transformation matrices and geometric algebra for neurosurgery
Expansion of stereotactic work envelope using transformation matrices and geometric algebra for neurosurgery Open
View article: Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry
Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry Open
Dopamine (DA) is a neurotransmitter present within the animal brain that is responsible for a wide range of physiologic functions, including motivation, reward, and movement control. Changes or dysfunction in the dynamics of DA release are…
View article: Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning
Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning Open
View article: Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine
Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine Open
Background Treatment of refractory bipolar disorder (BD) is extremely challenging. Deep brain stimulation (DBS) holds promise as an effective treatment intervention. However, we still understand very little about the mechanisms of DBS and …
View article: Improved circuitry and post-processing for interleaved fast-scan cyclic voltammetry and electrophysiology measurements
Improved circuitry and post-processing for interleaved fast-scan cyclic voltammetry and electrophysiology measurements Open
The combination of electrophysiology and electrochemistry acquisition methods using a single carbon fiber microelectrode (CFM) in the brain has enabled more extensive analysis of neurochemical release, neural activity, and animal behavior.…
View article: Techniques for Measurement of Serotonin: Implications in Neuropsychiatric Disorders and Advances in Absolute Value Recording Methods
Techniques for Measurement of Serotonin: Implications in Neuropsychiatric Disorders and Advances in Absolute Value Recording Methods Open
Serotonin (5-HT) is a monoamine neurotransmitter in the peripheral, enteric, and central nervous systems (CNS). Within the CNS, serotonin is principally involved in mood regulation and reward-seeking behaviors. It is a critical regulator i…
View article: Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine
Anti-manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine Open
Background Treatment of refractory bipolar disorder (BD) is extremely challenging. Deep brain stimulation (DBS) holds promise as an effective treatment intervention. However, we still understand very little about the mechanisms of DBS and …
View article: Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation
Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation Open
Introduction: Opioids are the leading cause of overdose death in the United States, accounting for almost 70,000 deaths in 2020. Deep brain stimulation (DBS) is a promising new treatment for substance use disorders. Here, we hypothesized t…
View article: Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission
Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission Open
Tourette syndrome is a childhood-onset neuropsychiatric disorder characterized by intrusive motor and vocal tics that can lead to self-injury and deleterious mental health complications. While dysfunction in striatal dopamine neurotransmis…
View article: High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens
High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens Open
Cocaine’s addictive properties stem from its capacity to increase tonic extracellular dopamine levels in the nucleus accumbens (NAc). The ventral tegmental area (VTA) is a principal source of NAc dopamine. To investigate how high frequency…
View article: Software for near-real-time voltammetric tracking of tonic neurotransmitter levels in vivo
Software for near-real-time voltammetric tracking of tonic neurotransmitter levels in vivo Open
Tonic extracellular neurotransmitter concentrations are important modulators of central network homeostasis. Disruptions in these tonic levels are thought to play a role in neurologic and psychiatric disease. Therefore, ways to improve the…
View article: Deep Brain Stimulation for Addictive Disorders—Where Are We Now?
Deep Brain Stimulation for Addictive Disorders—Where Are We Now? Open
In the face of a global epidemic of drug addiction, neglecting to develop new effective therapies will perpetuate the staggering human and economic costs of substance use. This review aims to summarize and evaluate the preclinical and clin…
View article: Table of Contents
Table of Contents Open
View article: Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens
Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens Open
Serotonin plays a vital role in drug addiction. Here, using N-shaped fast-scan cyclic voltammetry, we demonstrated the effect of cocaine on the phasic release of serotonin at the nucleus accumbens core. To the best of our knowledge, this h…
View article: Tonic Serotonin Measurements<i>In Vivo</i>Using N-Shaped Multiple Cyclic Square Wave Voltammetry
Tonic Serotonin Measurements<i>In Vivo</i>Using N-Shaped Multiple Cyclic Square Wave Voltammetry Open
Here, we present the development of a novel voltammetric technique, N-shaped multiple cyclic square wave voltammetry (N-MCSWV) and its application in vivo. It allows quantitative measurements of tonic extracellular levels of seroton…
View article: Feasibility of Applying Fourier Transform Electrochemical Impedance Spectroscopy in Fast Cyclic Square Wave Voltammetry for the<i>In Vivo</i>Measurement of Neurotransmitters
Feasibility of Applying Fourier Transform Electrochemical Impedance Spectroscopy in Fast Cyclic Square Wave Voltammetry for the<i>In Vivo</i>Measurement of Neurotransmitters Open
We previously reported on the use of fast cyclic square wave voltammetry (FCSWV) as a new voltammetric technique. Fourier transform electrochemical impedance spectroscopy (FTEIS) has recently been utilized to provide information that enabl…
View article: Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study Open
View article: Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry in vivo
Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry in vivo Open
For over 40 years, in vivo microdialysis techniques have been at the forefront in measuring the effects of illicit substances on brain tonic extracellular levels of dopamine that underlie many aspects of drug addiction. However, the size o…
View article: Biomarkers for Deep Brain Stimulation in Animal Models of Depression
Biomarkers for Deep Brain Stimulation in Animal Models of Depression Open
View article: Automatic and Reliable Quantification of Tonic Dopamine Concentrations <i>In Vivo</i> Using a Novel Probabilistic Inference Method
Automatic and Reliable Quantification of Tonic Dopamine Concentrations <i>In Vivo</i> Using a Novel Probabilistic Inference Method Open
Dysregulation of the neurotransmitter dopamine (DA) is implicated in several neuropsychiatric conditions. Multiple-cyclic square-wave voltammetry (MCSWV) is a state-of-the-art technique for measuring tonic DA levels with high sensitivity (…
View article: The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans
The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans Open
View article: Brain Metabolic Changes with Longitudinal Transcutaneous Afferent Patterned Stimulation in Essential Tremor Subjects
Brain Metabolic Changes with Longitudinal Transcutaneous Afferent Patterned Stimulation in Essential Tremor Subjects Open
Non-invasive peripheral nerve stimulation, also referred to as transcutaneous afferent patterned stimulation (TAPS), reduces hand tremor in essential tremor subjects. Longitudinal TAPS therapy alters cerebellar metabolism, which can be a c…
View article: A compact stereotactic system for image-guided surgical intervention
A compact stereotactic system for image-guided surgical intervention Open
Objective . Stereotactic technology enables fine navigation to small structures in the human body. While current stereotactic systems facilitate accurate targeting, they are mechanically cumbersome and limited in scope. Here, we hypothesiz…
View article: Evaluation of electrochemical methods for tonic dopamine detection in vivo
Evaluation of electrochemical methods for tonic dopamine detection in vivo Open
View article: Hypoxia-Associated Changes in Striatal Tonic Dopamine Release: Real-Time in vivo Measurements With a Novel Voltammetry Technique
Hypoxia-Associated Changes in Striatal Tonic Dopamine Release: Real-Time in vivo Measurements With a Novel Voltammetry Technique Open
MCSWV is a novel tool to study rapid changes in tonic dopamine release in vivo during hypoxia. We found a 6-fold increase in peak dopamine levels during hypoxia which was attenuated with AMPT pre-treatment. These changes are much lo…
View article: Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation
Clinical applications of neurochemical and electrophysiological measurements for closed-loop neurostimulation Open
The development of closed-loop deep brain stimulation (DBS) systems represents a significant opportunity for innovation in the clinical application of neurostimulation therapies. Despite the highly dynamic nature of neurological diseases, …