Charles D. Nichols
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View article: 5-HT2A receptors: Pharmacology and functional selectivity
5-HT2A receptors: Pharmacology and functional selectivity Open
View article: The selective 5-HT<sub>2A</sub>receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents
The selective 5-HT<sub>2A</sub>receptor agonist LPH-5 induces persistent and robust antidepressant-like effects in rodents Open
Psychedelic-assisted psychotherapy has over the last decade emerged as a promising treatment strategy for mental health disease, and the therapeutic potential in classical psychedelics such as psilocybin, LSD and 5-MeO-DMT is presently bei…
View article: Serotonin-2 Receptor Agonists Produce Anti-inflammatory Effects through Functionally Selective Mechanisms That Involve the Suppression of Disease-Induced Arginase 1 Expression
Serotonin-2 Receptor Agonists Produce Anti-inflammatory Effects through Functionally Selective Mechanisms That Involve the Suppression of Disease-Induced Arginase 1 Expression Open
Functional selectivity in the context of serotonin 2A (5-HT2A) receptor agonists is often described as differences psychedelic compounds have in the activation of Gq vs β-arrestin signaling in the brain and how that may relate t…
View article: If Everything Is Psychedelic, Then Nothing Is: A Response to O'Donnell et al. and Lepow et al.
If Everything Is Psychedelic, Then Nothing Is: A Response to O'Donnell et al. and Lepow et al. Open
View article: The Elephant in the Room: Personal Use of Psychedelics Among Psychedelic Researchers
The Elephant in the Room: Personal Use of Psychedelics Among Psychedelic Researchers Open
View article: Psychedelic Commercialization: A Wide-Spanning Overview of the Emerging Psychedelic Industry
Psychedelic Commercialization: A Wide-Spanning Overview of the Emerging Psychedelic Industry Open
Background: In the wake of positive clinical trial outcomes of psychedelic-assisted psychotherapy for the treatment of various psychiatric disorders, there has been an influx of financial investment into psychedelic drug development from t…
View article: Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders
Preclinical perspectives on the mechanisms underlying the therapeutic actions of psilocybin in psychiatric disorders Open
Psychedelic compounds have shown extraordinary potential in treating a wide range of neuropsychiatric disorders. Psilocybin, for example, has now been shown in several clinical trials to induce a rapid (within days) and persistent (3-12 mo…
View article: A Single Administration of Psilocybin Persistently Rescues Cognitive Deficits Caused by Adolescent Chronic Restraint Stress Without Long-Term Changes in Synaptic Protein Gene Expression in a Rat Experimental System with Translational Relevance to Depression
A Single Administration of Psilocybin Persistently Rescues Cognitive Deficits Caused by Adolescent Chronic Restraint Stress Without Long-Term Changes in Synaptic Protein Gene Expression in a Rat Experimental System with Translational Relevance to Depression Open
Introduction: Psilocybin has shown long-lasting antidepressant effects in preclinical and clinical trials, but the mechanisms responsible are unclear. As both passive coping strategies and pattern separation deficits are characteristics of…
View article: Past, Present, and Future of Psychedelics: A <i>Psychedelic Medicine</i> Roundtable Discussion
Past, Present, and Future of Psychedelics: A <i>Psychedelic Medicine</i> Roundtable Discussion Open
View article: Proposed Consensus Statement on Defining Psychedelic Drugs
Proposed Consensus Statement on Defining Psychedelic Drugs Open
View article: Editors' Introduction to <i>Psychedelic Medicine</i>
Editors' Introduction to <i>Psychedelic Medicine</i> Open
View article: Psychedelics as potent anti-inflammatory therapeutics
Psychedelics as potent anti-inflammatory therapeutics Open
Psychedelics have seen a resurgence of interest from both the scientific and lay community in recent years. Psychedelics are known for their ability to produce profound perceptual alterations, ego dissolution, and separation from reality i…
View article: Psychedelic drug abuse potential assessment research for new drug applications and Controlled Substances Act scheduling
Psychedelic drug abuse potential assessment research for new drug applications and Controlled Substances Act scheduling Open
New medicines containing classic hallucinogenic and entactogenic psychedelic substance are under development for various psychiatric and neurological disorders. Many of these, including psilocybin, lysergic acid diethylamide (LSD), and 3,4…
View article: Effects of Tai Chi Practice on Brain as Assessed with Neuroimaging Techniques – A Scoping Review
Effects of Tai Chi Practice on Brain as Assessed with Neuroimaging Techniques – A Scoping Review Open
1,2,5].For example, TC has played a significant role in the recovery of patients who suffered from stroke, Parkinson disease, traumatic brain injury, and multiple sclerosis [6,7].Because of its beneficial effects on health promotion and im…
View article: Preface to the special issue “Psychedelics and Neurochemistry”
Preface to the special issue “Psychedelics and Neurochemistry” Open
Psychedelics are a relatively recent field of research that had not gained much support half a century ago, yet it developed into a much acknowledged, highly relevant field that extends to many people's lives. Psychedelics have demonstrate…
View article: Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD
Pharmahuasca and DMT Rescue ROS Production and Differentially Expressed Genes Observed after Predator and Psychosocial Stress: Relevance to Human PTSD Open
Post-traumatic stress disorder (PTSD) is associated with cognitive deficits, oxidative stress, and inflammation. Animal models have recapitulated features of PTSD, but no comparative RNA sequencing analysis of differentially expressed gene…
View article: Manual Therapy Treatment for Penile Pain- A Clinical Case Report with 6-Month Follow-up
Manual Therapy Treatment for Penile Pain- A Clinical Case Report with 6-Month Follow-up Open
By utilizing a deductive reasoning process related to the penile area, clinicians may better apply manual therapy techniques for successful treatment.
View article: LSD induces increased signalling entropy in rats’ prefrontal cortex
LSD induces increased signalling entropy in rats’ prefrontal cortex Open
Psychedelic drugs are gaining attention from the scientific community as potential new compounds for the treatment of psychiatric diseases such as mood and substance use disorders. The 5-HT 2A receptor has been identified as the main molec…
View article: Pharmahuasca Reduces ROS Production and inflammatory Gene Expression in the Brain in a Model of PTSD: Exploration by RNA Sequencing
Pharmahuasca Reduces ROS Production and inflammatory Gene Expression in the Brain in a Model of PTSD: Exploration by RNA Sequencing Open
Post-traumatic stress disorder (PTSD) is associated with cognitive deficits, oxidative stress and inflammation. N,N-dimethyltryptamine (DMT) is a known neuroprotective, antioxidant, anti-inflammatory, and psychoplastogen with antidepressan…
View article: Structure–Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore
Structure–Activity Relationship Analysis of Psychedelics in a Rat Model of Asthma Reveals the Anti-Inflammatory Pharmacophore Open
Psychedelic drugs can exert potent anti-inflammatory effects. However, anti-inflammatory effects do not appear to correlate with behavioral activity, suggesting different underlying mechanisms. We hypothesized that the distinct structural …
View article: Virus-induced serotonin production correlates with severity of inflammation-associated ocular disease: Therapeutic potential of 5HT2A receptor agonists
Virus-induced serotonin production correlates with severity of inflammation-associated ocular disease: Therapeutic potential of 5HT2A receptor agonists Open
View article: Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression Open
Psilocybin shows efficacy to alleviate depression in human clinical trials for six or more months after only one or two treatments. Another hallucinogenic drug, esketamine, has recently been U.S. Food and Drug Administration (FDA)-approved…
View article: Population Survey Data Informing the Therapeutic Potential of Classic and Novel Phenethylamine, Tryptamine, and Lysergamide Psychedelics
Population Survey Data Informing the Therapeutic Potential of Classic and Novel Phenethylamine, Tryptamine, and Lysergamide Psychedelics Open
These findings, which may be driven by differences in pharmacodynamics, suggest that classic tryptamines may hold the greatest therapeutic potential of the psychedelics, whereas novel phenethylamines may pose risk for harm. The present fin…
View article: Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers
Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers Open
Abstract Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT 2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation …
View article: Microdosing psychedelics: More questions than answers? An overview and suggestions for future research
Microdosing psychedelics: More questions than answers? An overview and suggestions for future research Open
Background: In the past few years, the issue of ‘microdosing’ psychedelics has been openly discussed in the public arena where claims have been made about their positive effect on mood state and cognitive processes such as concentration. H…
View article: The Creation of Fictional History in the Tequila Industry
The Creation of Fictional History in the Tequila Industry Open
The creation of fictional history in the tequila industry due to changes in government policy, trade agreements and big business.
View article: Psychedelics Recruit Multiple Cellular Types and Produce Complex Transcriptional Responses Within the Brain
Psychedelics Recruit Multiple Cellular Types and Produce Complex Transcriptional Responses Within the Brain Open
There has recently been a resurgence of interest in psychedelics, substances that profoundly alter perception and cognition and have recently demonstrated therapeutic efficacy to treat anxiety, depression, and addiction in the clinic. The …