Charles E. Spritzer
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View article: Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage
Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage Open
The 3-mile treadmill run induced a significant decrease in both tibial and femoral cartilage thickness; however, this was largely ameliorated the following morning.
View article: Does Tibial Plateau Slope and Depth Influence ACL Strain In Vivo?
Does Tibial Plateau Slope and Depth Influence ACL Strain In Vivo? Open
Background: The anterior cruciate ligament (ACL) is loaded under tension when the tibia translates anteriorly relative to the femur. The shape of the articular surfaces of the tibiofemoral joint may influence the amount of anterior tibial …
View article: A comparison of three methods for establishing an ACL reference length in vivo
A comparison of three methods for establishing an ACL reference length in vivo Open
As anterior cruciate ligament (ACL) injuries are highly prevalent among active individuals, it is vital to better understand the loading conditions which lead to injury. One method for doing so is through measurement of dynamic, in vivo AC…
View article: High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging
High angular resolution diffusion imaging (HARDI) of porcine menisci: a comparison of diffusion tensor imaging and generalized q-sampling imaging Open
HARDI acquisition with GQI reconstruction more accurately resolves the complex 3D collagen architecture of the meniscus compared to DTI reconstruction. In the future, these technologies have the potential to nondestructively assess both no…
View article: Influence of running on femoroacetabular joint bone‐to‐bone distances
Influence of running on femoroacetabular joint bone‐to‐bone distances Open
There is limited data quantifying the influence of running on hip cartilage mechanics. The goal of this investigation was to quantify changes in hip joint bone‐to‐bone distance in response to a 3‐mile treadmill run. We acquired magnetic re…
Automated segmentation and prediction of intervertebral disc morphology and uniaxial deformations from MRI Open
This study demonstrated that a deep learning framework can precisely and reliably automate measures of IVD function, drastically improving the throughput of these time-intensive methods.
View article: Prospective Multireader Evaluation of Photon-counting CT for Multiple Myeloma Screening
Prospective Multireader Evaluation of Photon-counting CT for Multiple Myeloma Screening Open
Purpose To determine whether photon-counting CT (PCCT) acquisition of whole-body CT images provides similar quantitative image quality and reader satisfaction for multiple myeloma screening at lower radiation doses than does standard energ…
View article: The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain
The Influence of Obesity and Meniscal Coverage on In Vivo Tibial Cartilage Thickness and Strain Open
Background: Obesity, which potentially increases loading at the knee, is a common and modifiable risk factor for the development of knee osteoarthritis. The menisci play an important role in distributing joint loads to the underlying carti…
View article: Dose and Recovery Response of Patellofemoral Cartilage Deformations to Running
Dose and Recovery Response of Patellofemoral Cartilage Deformations to Running Open
Background: Running is a common recreational activity that provides many health benefits. However, it remains unclear how patellofemoral cartilage is affected by varied running distances and how long it takes the cartilage to recover to it…
The Characteristic Recovery Time as a Novel, Noninvasive Metric for Assessing In Vivo Cartilage Mechanical Function Open
Osteoarthritis (OA) is a disease characterized by the degeneration of cartilage tissue, and is a leading cause of disability in the United States. The clinical diagnosis of OA includes the presence of pain and radiographic imaging findings…
View article: In Vivo Anterior Cruciate Ligament Deformation During a Single-Legged Jump Measured by Magnetic Resonance Imaging and High-Speed Biplanar Radiography
In Vivo Anterior Cruciate Ligament Deformation During a Single-Legged Jump Measured by Magnetic Resonance Imaging and High-Speed Biplanar Radiography Open
Background: The in vivo mechanics of the anterior cruciate ligament (ACL) and its bundles during dynamic activities are not completely understood. An improved understanding of how the ACL stabilizes the knee is likely to aid in the identif…
View article: Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer
Pharmacodynamic study of radium-223 in men with bone metastatic castration resistant prostate cancer Open
Osteomimicry may contribute in part to the uptake of radium-223 within bone metastases and may thereby enhance the therapeutic benefit of this bone targeting radiotherapy.