Gutteridge Jean-Charles
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View article: Chronic Obstructive Pulmonary Disease and Its Effect on Red Blood Cell Indices
Chronic Obstructive Pulmonary Disease and Its Effect on Red Blood Cell Indices Open
Chronic obstructive pulmonary disease (COPD) constitutes a set of heterogeneous symptoms affecting millions of people worldwide. The associated comorbidities developing in COPD involve dysregulation in physiological pathways resulting from…
View article: JAK2 and TET2 Mutation in Polycythemia Vera
JAK2 and TET2 Mutation in Polycythemia Vera Open
The Ten-Eleven Translocation-2 (TET2) gene, located on chromosome 4q24, has been implicated in hematological malignancies. The TET2 gene shows mutations in variable myeloid malignancies with the involvement of 15% of myeloproliferative neo…
View article: Metabolic Acidosis in Leukemia
Metabolic Acidosis in Leukemia Open
In 2020, the incidence of leukemia was 474,519 with 311,594 mortality worldwide. In 2021, the American Cancer Society (ACS) has estimated 61,090 new cases of leukemia to occur within the United States. It has also been reported that the mo…
View article: Role of Kisspeptin on Hypothalamic-Pituitary-Gonadal Pathology and Its Effect on Reproduction
Role of Kisspeptin on Hypothalamic-Pituitary-Gonadal Pathology and Its Effect on Reproduction Open
Kisspeptin is a neuropeptide that plays a significant role in human reproduction by its action on the hypothalamic-pituitary-gonadal (HPG) axis and functions through a G-protein-coupled receptor called G-protein-coupled receptor 54/kisspep…
View article: Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus
Non-Alcoholic Fatty Liver Disease and Its Association With Diabetes Mellitus Open
There is a bidirectional relationship between non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). The liver has a vital role in the pathophysiology of both diseases as it leads to the development of insulin resis…
View article: Stem Cell Therapy and Its Significance in Pain Management
Stem Cell Therapy and Its Significance in Pain Management Open
Pain management has always been a challenging issue, which is why it has been a major focus of many rigorous studies. Chronic pain which typically lasts for more than three months is prevalent at an astounding rate of 11% to 19% of the adu…
View article: Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome
Factor V Leiden G1691A and Prothrombin Gene G20210A Mutations on Pregnancy Outcome Open
Factor V Leiden (FVL) G1619A mutation and prothrombin gene (PTG) G20210A are the most common inherited thrombophilias. They have been associated with various obstetric complications such as venous thromboembolism, recurrent pregnancy loss,…
View article: 13q14 Deletion and Its Effect on Prognosis of Chronic Lymphocytic Leukemia
13q14 Deletion and Its Effect on Prognosis of Chronic Lymphocytic Leukemia Open
Chronic lymphocytic leukemia (CLL) is the most common leukemia affecting adults. CLL results due to uncontrolled accumulation of B lymphocytes in the body with the clinical spectrum ranging from comparatively benign disease to an aggressiv…
View article: Depression and Its Effect on the Menstrual Cycle
Depression and Its Effect on the Menstrual Cycle Open
A strong association is noted between depression and early perimenopause as well as menopause. The association was found to be the greatest in women with natural menopause at the age less than 40 years. Excessive corticotropin-releasing ho…