Charles C. Hsu
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Implications of primary tumor site and fraction size on outcomes of palliative radiation for osseous metastases Open
Purpose This study reviewed palliative radiation therapy (RT) practices and outcomes and compared the percentage of remaining life spent receiving RT (PRLSRT) in patients treated for osseous metastases. Methods A retrospective analysis was…
An Introductory Approach to Time-Series Data Preparation and Analysis Open
Machine learning (ML)/Artificial Intelligence (AI) has widespread applications and has revolutionized many industries due to advanced and matured sensor technology, as well as large-scale data collection efforts. One of the key tasks for e…
Multicenter Evaluation of Radiation and Immune Checkpoint Inhibitor Therapy in Mucosal Melanoma and Review of Recent Literature Open
High rates of local control were achieved with RT with or without oncologic resection and ICI for localized and locally advanced MM. In particular, favorable local control was possible even for patients with unresectable or node-positive d…
Editorial: Regulation of PI3K/Akt signaling pathway: A feasible approach for natural neuroprotective agents to treat various neuron injury-related diseases Open
Neuron injury is closely associated with the development of various diseases, such as Alzheimer's disease, spinal cord injury, ischemic stroke, and depression. The phosphoinositide-3-kinase (PI3K)/protein kinase B(Akt) signaling pathway is…
Editorial: Leveraging machine learning for omics-driven biomarker discovery Open
EDITORIAL article Front. Mol. Biosci., 09 January 2023Sec. Molecular Diagnostics and Therapeutics Volume 9 - 2022 | https://doi.org/10.3389/fmolb.2022.1119644
Pilot Study: Texture Analysis of PET Imaging Demonstrates Changes in <sup>18</sup>F-FDG Uptake of the Brain After Prophylactic Cranial Irradiation Open
Prophylactic cranial irradiation (PCI) is used to decrease the probability of developing brain metastases in patients with small cell lung cancer and has been linked to deleterious cognitive effects. Although no well-established imaging ma…
Prospective Study of Use of Edmonton Symptom Assessment Scale Versus Routine Symptom Management During Weekly Radiation Treatment Visits Open
PURPOSE: During radiotherapy (RT), patient symptoms are evaluated and managed weekly during physician on-treatment visits (OTVs). The Edmonton Symptom Assessment Scale (ESAS) is a 9-symptom validated self-assessment tool for reporting comm…
Regional Changes in Brain <sup>18</sup>F-FDG Uptake After Prophylactic Cranial Irradiation and Chemotherapy in Small Cell Lung Cancer May Reflect Functional Changes Open
Chemotherapy followed by prophylactic cranial irradiation (PCI) is associated with increased survival in patients with small cell lung cancer but is associated with fatigue and cognitive impairment. This retrospective study evaluated regio…
Smad4 Loss Correlates With Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation Open
Objectives The tumor suppressor gene SMAD4 (DPC4) is genetically inactivated in approximately half of pancreatic ductal adenocarcinomas (PDAs). We examined whether Smad4 tumor status was associated with outcomes after adjuvant chemoradiati…
Imaging Lung Cancer by Using Chemical Exchange Saturation Transfer MRI With Retrospective Respiration Gating Open
Performing chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) in lung tissue is difficult because of motion artifacts. We, therefore, developed a CEST MRI acquisition and analysis method that performs retrospecti…