Charles J. Cho
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View article: Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction
Inhibition of Ribosome Biogenesis In Vivo Causes p53-Dependent Death and p53-Independent Dysfunction Open
Together, our results provide initial insights into how differentiated cells respond to defects in RiBi and translation in vivo in various physiological contexts.
View article: IFRD1 is required for maintenance of bladder epithelial homeostasis
IFRD1 is required for maintenance of bladder epithelial homeostasis Open
The maintenance of homeostasis and rapid regeneration of the urothelium following stress are critical for bladder function. Here, we identify a key role for IFRD1 in maintaining urothelial homeostasis in a mouse model. We demonstrate that …
View article: Inhibition of Ribosome Biogenesis<i>in vivo</i>Causes p53-Dependent Death and p53-Independent Dysfunction
Inhibition of Ribosome Biogenesis<i>in vivo</i>Causes p53-Dependent Death and p53-Independent Dysfunction Open
Ribosomes are critical for cell function; their synthesis (known as ribosome biogenesis; “RiBi”) is complex and energy-intensive. Surprisingly little is known about RiBi in differentiated cells in vivo in adult tissue. Here, we generated m…
View article: A new role for IFRD1 in regulation of ER stress in bladder epithelial homeostasis
A new role for IFRD1 in regulation of ER stress in bladder epithelial homeostasis Open
A healthy bladder requires the homeostatic maintenance of and rapid regeneration of urothelium upon stress/injury/infection. Several factors have been identified to play important roles in urothelial development, injury and disease respons…
View article: The coordinated management of ribosome and translation during injury and regeneration
The coordinated management of ribosome and translation during injury and regeneration Open
Diverse acute and chronic injuries induce damage responses in the gastrointestinal (GI) system, and numerous cell types in the gastrointestinal tract demonstrate remarkable resilience, adaptability, and regenerative capacity in response to…
View article: Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium
Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium Open
Cells recognize both foreign and host-derived double-stranded RNA (dsRNA) via a signaling pathway that is usually studied in the context of viral infection. It has become increasingly clear that the sensing and handling of endogenous dsRNA…
View article: ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis Open
Here, we find the MIST1 (BHLHA15) transcriptional target ELAPOR1 is an evolutionarily conserved, trans-Golgi/late endosome M6PR domain-containing protein that is specific to gastric zymogenic cells and required for normal secretory granule…
View article: Paligenosis: Cellular Remodeling During Tissue Repair
Paligenosis: Cellular Remodeling During Tissue Repair Open
Complex multicellular organisms have evolved specific mechanisms to replenish cells in homeostasis and during repair. Here, we discuss how emerging technologies (e.g., single-cell RNA sequencing) challenge the concept that tissue renewal i…
View article: ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis
ELAPOR1 is a secretory granule maturation-promoting factor that is lost during paligenosis Open
Supplementary figures and tables
View article: Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury
Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury Open
BACKGROUND & AIMS Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising from ADM, the associat…
View article: Supplementary Material for: Close Observation versus Additional Surgery after Noncurative Endoscopic Resection of Esophageal Squamous Cell Carcinoma
Supplementary Material for: Close Observation versus Additional Surgery after Noncurative Endoscopic Resection of Esophageal Squamous Cell Carcinoma Open
Introduction: After noncurative endoscopic submucosal dissection (ESD) of superficial esophageal squamous cell carcinoma (SESCC), additional esophagectomy is generally recommended. However, considering its high mortality and morbidity, it …
View article: Autophagy repurposes cells during paligenosis
Autophagy repurposes cells during paligenosis Open
Differentiated cells have evolved paligenosis, a conserved program to return to a stem or progenitor state and reenter the cell cycle to fuel tissue repair. Paligenosis comprises three sequential stages: 1) quenching of MTORC1 activity wit…
View article: ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation
ADAR1 Suppresses Interferon Signaling in Gastric Cancer Cells by MicroRNA-302a-Mediated IRF9/STAT1 Regulation Open
ADAR (adenosine deaminase acting on RNA) catalyzes the deamination of adenosine to generate inosine, through its binding to double-stranded RNA (dsRNA), a phenomenon known as RNA editing. One of the functions of ADAR1 is suppressing the ty…
View article: Long-Term Survival and Tumor Recurrence in Patients with Superficial Esophageal Cancer after Complete Non-Curative Endoscopic Resection: A Single-Center Case Series
Long-Term Survival and Tumor Recurrence in Patients with Superficial Esophageal Cancer after Complete Non-Curative Endoscopic Resection: A Single-Center Case Series Open
Patients with non-curatively resected SEC showed good long-term survival outcomes. Given the similar oncologic outcomes, close observation may be an option with appropriate caution taken for patients who are medically unfit to receive addi…
View article: Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma
Atrophic and Metaplastic Progression in the Background Mucosa of Patients with Gastric Adenoma Open
Atrophic and metaplastic progression is extensive and severe in gastric adenoma patients. A surveillance strategy for metachronous tumors should be applied similarly for patients with adenoma or EGC.
View article: Characteristics of Missed Simultaneous Gastric Lesions Based on Double-Check Analysis of the Endoscopic Image
Characteristics of Missed Simultaneous Gastric Lesions Based on Double-Check Analysis of the Endoscopic Image Open
Lesions disregarded or unnoticed during endoscopic examination were the main reason for missed diagnosis of simultaneous lesions. Endoscopists should consider the possibility of simultaneous lesions and attempt to meticulously evaluate the…
View article: Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer receiving multimodality therapy
Clinical implications of endoscopic ultrasonography non-traversability in patients with locoregional esophageal cancer receiving multimodality therapy Open
EUS non-traversability has significant negative prognostic implications in patients with advanced locoregional squamous EC receiving preoperative CRT followed by esophagectomy.