Charles L. Sprung
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View article: REMAP-CAP corticosteroids: yet, another swing of the pendulum?
REMAP-CAP corticosteroids: yet, another swing of the pendulum? Open
View article: End-of-life decision disparities according to the gross national income in critically ill patients: a secondary analysis of the ETHICUS-2 study
End-of-life decision disparities according to the gross national income in critically ill patients: a secondary analysis of the ETHICUS-2 study Open
View article: European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit
European Society of Intensive Care Medicine guidelines on end of life and palliative care in the intensive care unit Open
View article: End-of-life practices in Hong Kong intensive care units: results from the Ethicus-2 study
End-of-life practices in Hong Kong intensive care units: results from the Ethicus-2 study Open
Life-sustaining treatment limitations are common in Hong Kong ICUs; shared decision-making between physicians and families in the patient's best interest is the predominant model. Loss of decision-making capacity is common at the end of li…
View article: Limitations of life-sustaining therapies in South Africa
Limitations of life-sustaining therapies in South Africa Open
Withholding was more common than withdrawing treatment both in SA and worldwide, although both were significantly less frequent in SA compared with the world average.
View article: The impact of religion on changes in end-of-life practices in European intensive care units: a comparative analysis over 16 years
The impact of religion on changes in end-of-life practices in European intensive care units: a comparative analysis over 16 years Open
View article: Ethical considerations of medical nutritional therapy at end of life: the Israel perspective
Ethical considerations of medical nutritional therapy at end of life: the Israel perspective Open
Summary: The major ethical dilemma regarding feeding a person at the end of their life in Israel is related to the medical team's ability to not provide food. In addition to the medical indications, the decision-making process needs to inc…
View article: Variations in nurse involvement in end-of-life practices in intensive care units worldwide (ETHICUS-2): a prospective observational study.
Variations in nurse involvement in end-of-life practices in intensive care units worldwide (ETHICUS-2): a prospective observational study. Open
Purpose explore global ICU nurse involvement in end of life decisions, ETHICUS-2 prospective multinational, observational study was performed. Methods This is a secondary analysis of data obtained from the ETHICUS-2 study. Patients were fo…
View article: Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock
Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock Open
BACKGROUND: Trials and study-level meta-analyses have failed to resolve the role of corticosteroids in the management of patients with septic shock. Patient-level meta-analyses may provide more precise estimates of treatment effects, parti…
View article: Critical Care Staffing in Pandemics and Disasters
Critical Care Staffing in Pandemics and Disasters Open
View article: Outcome predictors and patient progress following delivery in pregnant and postpartum patients with severe COVID-19 pneumonitis in intensive care units in Israel (OB-COVICU): a nationwide cohort study
Outcome predictors and patient progress following delivery in pregnant and postpartum patients with severe COVID-19 pneumonitis in intensive care units in Israel (OB-COVICU): a nationwide cohort study Open
View article: The Impact of the Society of Critical Care Medicine’s Flagship Journal: Critical Care Medicine: Reflections of Critical Care Pioneers
The Impact of the Society of Critical Care Medicine’s Flagship Journal: Critical Care Medicine: Reflections of Critical Care Pioneers Open
On the 50th anniversary of the Society of Critical Care Medicine’s journal Critical Care Medicine , critical care pioneers reflect on the importance of the journal to their careers and to the development of the field of adult and pediatric…
View article: End-of-life practices in 11 German intensive care units
End-of-life practices in 11 German intensive care units Open
View article: Outcomes and Predictors of 28-Day Mortality in Patients With Solid Tumors and Septic Shock Defined by Third International Consensus Definitions for Sepsis and Septic Shock Criteria
Outcomes and Predictors of 28-Day Mortality in Patients With Solid Tumors and Septic Shock Defined by Third International Consensus Definitions for Sepsis and Septic Shock Criteria Open
View article: Derivation and performance of an end-of-life practice score aimed at interpreting worldwide treatment-limiting decisions in the critically ill
Derivation and performance of an end-of-life practice score aimed at interpreting worldwide treatment-limiting decisions in the critically ill Open
View article: Outcomes and Predictors of 28-Day Mortality in Patients With Hematologic Malignancies and Septic Shock Defined by Sepsis-3 Criteria
Outcomes and Predictors of 28-Day Mortality in Patients With Hematologic Malignancies and Septic Shock Defined by Sepsis-3 Criteria Open
Background: To describe short-term outcomes and independent predictors of 28-dayx mortality in adult patients with hematologic malignancies and septic shock defined by the new Third International Consensus Definitions (Sepsis-3) criteria. …
View article: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021 Open
INTRODUCTION Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of people around the world each year and killing b…
View article: Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 Open
View article: Mass Critical Care Surge Response During COVID-19
Mass Critical Care Surge Response During COVID-19 Open
View article: The Influence of Geography, Religion, Religiosity and Institutional Factors on Worldwide End-of-Life Care for the Critically Ill: The WELPICUS Study
The Influence of Geography, Religion, Religiosity and Institutional Factors on Worldwide End-of-Life Care for the Critically Ill: The WELPICUS Study Open
Objective: To evaluate the association between provider religion and religiosity and consensus about end-of-life care and explore if geographical and institutional factors contribute to variability in practice. Methods: Using a modified De…
View article: Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock
Use of IFNγ/IL10 Ratio for Stratification of Hydrocortisone Therapy in Patients With Septic Shock Open
Large clinical trials testing hydrocortisone therapy in septic shock have produced conflicting results. Subgroups may benefit of hydrocortisone treatment depending on their individual immune response. We performed an exploratory analysis o…
View article: Assessment of Machine Learning to Estimate the Individual Treatment Effect of Corticosteroids in Septic Shock
Assessment of Machine Learning to Estimate the Individual Treatment Effect of Corticosteroids in Septic Shock Open
These findings suggest that an individualized treatment strategy to decide which patient with septic shock to treat with corticosteroids yielded positive net benefit regardless of potential corticosteroid-associated side effects.
View article: Pain management during the withholding and withdrawal of life support in critically ill patients at the end-of-life: a systematic review and meta-analysis
Pain management during the withholding and withdrawal of life support in critically ill patients at the end-of-life: a systematic review and meta-analysis Open
View article: Israeli Position Paper: Triage Decisions for Severely Ill Patients During the COVID-19 Pandemic. Joint Commission of the Israel National Bioethics Council, the Ethics Bureau of the Israel Medical Association and Representatives from the Israeli Ministry of Health
Israeli Position Paper: Triage Decisions for Severely Ill Patients During the COVID-19 Pandemic. Joint Commission of the Israel National Bioethics Council, the Ethics Bureau of the Israel Medical Association and Representatives from the Israeli Ministry of Health Open
The Israeli consensus document and pragmatic medical triage protocol offer a societal and medical roadmap for allocating scarce resources during the COVID-19 pandemic or other disasters.
View article: Israeli Position Paper
Israeli Position Paper Open
View article: Adult ICU Triage During the Coronavirus Disease 2019 Pandemic: Who Will Live and Who Will Die? Recommendations to Improve Survival*
Adult ICU Triage During the Coronavirus Disease 2019 Pandemic: Who Will Live and Who Will Die? Recommendations to Improve Survival* Open
Objectives: Coronavirus disease 2019 patients are currently overwhelming the world’s healthcare systems. This article provides practical guidance to front-line physicians forced to make critical rationing decisions. Data Sources: PubMed an…
View article: Triage of Scarce Critical Care Resources in COVID-19 An Implementation Guide for Regional Allocation
Triage of Scarce Critical Care Resources in COVID-19 An Implementation Guide for Regional Allocation Open
View article: Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016
Changes in End-of-Life Practices in European Intensive Care Units From 1999 to 2016 Open
Among patients who had treatment limitations or died in 22 European ICUs in 2015-2016, compared with data reported from the same ICUs in 1999-2000, limitations in life-prolonging therapies occurred significantly more frequently and death w…
View article: Eight things we would never do regarding end-of-life care in the ICU
Eight things we would never do regarding end-of-life care in the ICU Open
View article: Obstacles to the successful introduction of an electronic hand hygiene monitoring system, a cohort observational study
Obstacles to the successful introduction of an electronic hand hygiene monitoring system, a cohort observational study Open