Charles Laurin
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View article: Lasso Meta-Regression and Its Application to Psychiatric Genomics
Lasso Meta-Regression and Its Application to Psychiatric Genomics Open
Meta-analysis is an essential technique in psychiatric genomics. Heterogeneity of the effect sizes included in a meta-analysis can reduce its statistical power. Meta-regression provides a way to identify study-level covariates that are ass…
View article: Variable Selection Through Regularized Regression: Intervals, Interactions, and Informal Inference
Variable Selection Through Regularized Regression: Intervals, Interactions, and Informal Inference Open
View article: Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases Open
View article: Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases
Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases Open
The human proteome is a major source of therapeutic targets. Recent genetic association analyses of the plasma proteome enable systematic evaluation of the causal consequences of variation in plasma protein levels. Here, we estimated the e…
View article: Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors Open
View article: Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors Open
Birth weight (BW) variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. These associations have been proposed to reflect the lifelo…
View article: The MR-Base platform supports systematic causal inference across the human phenome
The MR-Base platform supports systematic causal inference across the human phenome Open
Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, …
View article: Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans
Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans Open
Genomic imprinting is an epigenetic mechanism leading to parent-of-origin silencing of alleles. So far, the precise number of imprinted regions in humans is uncertain. In this study, we leveraged genome-wide DNA methylation in whole blood …
View article: Author response: The MR-Base platform supports systematic causal inference across the human phenome
Author response: The MR-Base platform supports systematic causal inference across the human phenome Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Results from genome-wide association studies (G…
View article: Abstract
Abstract Open
Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SMR) and bypassing the need for individual-level data. However, …
View article: Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices
Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices Open
View article: Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness Open
Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, we perform a large-…
View article: Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals
Imprinted loci may be more widespread in humans than previously appreciated and enable limited assignment of parental allelic transmissions in unrelated individuals Open
Genomic imprinting is an epigenetic mechanism leading to parent-of-origin dependent gene expression. So far, the precise number of imprinted genes in humans is uncertain. In this study, we leveraged genome-wide DNA methylation in whole blo…
View article: Partitioning phenotypic variance due to parent-of-origin effects using genomic relatedness matrices
Partitioning phenotypic variance due to parent-of-origin effects using genomic relatedness matrices Open
We propose a method, G-REMLadp, to estimate phenotypic variance attributable to parent-of-origin effects (POEs) across the genome. G-REMLadp uses restricted maximum likelihood analysis of genome-wide genotypic relatedness matrices from pha…
View article: MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations
MR-Base: a platform for systematic causal inference across the phenome using billions of genetic associations Open
Published genetic associations can be used to infer causal relationships between phenotypes, bypassing the need for individual-level genotype or phenotype data. We have curated complete summary data from 1094 genome-wide association studie…
View article: LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis Open
Motivation LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into fu…
View article: HAPRAP: a haplotype-based iterative method for statistical fine mapping using GWAS summary statistics
HAPRAP: a haplotype-based iterative method for statistical fine mapping using GWAS summary statistics Open
Motivation Fine mapping is a widely used approach for identifying the causal variant(s) at disease-associated loci. Standard methods (e.g. multiple regression) require individual level genotypes. Recent fine mapping methods using summary-l…
View article: The use of vector bootstrapping to improve variable selection precision in Lasso models
The use of vector bootstrapping to improve variable selection precision in Lasso models Open
The Lasso is a shrinkage regression method that is widely used for variable selection in statistical genetics. Commonly, K -fold cross-validation is used to fit a Lasso model. This is sometimes followed by using bootstrap confidence interv…
View article: LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis Open
Motivation LD score regression is a reliable and efficient method of using genome-wide association study (GWAS) summary-level results data to estimate the SNP heritability of complex traits and diseases, partition this heritability into fu…
View article: Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity
Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity Open
We found no consistent evidence of association between fish consumption and GWG, and our results indicate that the association between dietary fish and GWG has little or no dependency on GRS or individual SNPs.
View article: Genetic Analyses Benefit From Using Less Heterogeneous Phenotypes: An Illustration With the Hospital Anxiety and Depression Scale (HADS)
Genetic Analyses Benefit From Using Less Heterogeneous Phenotypes: An Illustration With the Hospital Anxiety and Depression Scale (HADS) Open
Phenotypic heterogeneity of depression has been cited as one of the causes of the limited success to detect genetic variants in genome‐wide studies. The 7‐item Hospital Anxiety and Depression Scale (HADS‐D) was developed to detect depressi…