Charles M. Thurlow
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View article: Molecular investigation of <i>Treponema pallidum</i> strains associated with ocular syphilis in the United States, 2016–2020
Molecular investigation of <i>Treponema pallidum</i> strains associated with ocular syphilis in the United States, 2016–2020 Open
Ocular syphilis is a serious complication of Treponema pallidum infection that can occur at any stage of syphilis and affect any eye structure. It remains unknown if certain T. pallidum strains are associated with ocular infections; theref…
View article: Round Bodies Detected by Treponema pallidum Immunohistochemical Stain in Two Cases of Cutaneous Syphilitic Gummata
Round Bodies Detected by Treponema pallidum Immunohistochemical Stain in Two Cases of Cutaneous Syphilitic Gummata Open
Tertiary syphilis may present a diagnostic challenge due to negative nontreponemal serologies in up to 30% of cases and frequent lack of identifiable spirochetes on histopathology or other direct detection tests. We report 2 cases of round…
View article: Selective Whole-Genome Amplification as a Tool to Enrich Specimens with Low Treponema pallidum Genomic DNA Copies for Whole-Genome Sequencing
Selective Whole-Genome Amplification as a Tool to Enrich Specimens with Low Treponema pallidum Genomic DNA Copies for Whole-Genome Sequencing Open
Syphilis is a sexually transmitted, disseminated acute and chronic infection caused by the bacterial pathogen Treponema pallidum subspecies pallidum . Primary syphilis typically presents as single or multiple mucocutaneous lesions and, if …
View article: Selective whole genome amplification as a tool to enrich specimens with low<i>Treponema pallidum</i>genomic DNA copies for whole genome sequencing
Selective whole genome amplification as a tool to enrich specimens with low<i>Treponema pallidum</i>genomic DNA copies for whole genome sequencing Open
Downstream next generation sequencing (NGS) of the syphilis spirochete Treponema pallidum subspecies pallidum ( T. pallidum ) is hindered by low bacterial loads and the overwhelming presence of background metagenomic DNA in clinical specim…
View article: O07.3 Molecular investigation of Treponema pallidum strains associated with ocular syphilis in the United States
O07.3 Molecular investigation of Treponema pallidum strains associated with ocular syphilis in the United States Open
Background Ocular syphilis cases continue to be identified in the United States since two clusters were reported in late 2014 into early 2015. Ocular syphilis (OS) is an inflammatory eye condition that can occur at any stage of syphilis wi…
View article: Successful isolation of Treponema pallidum strains from patients’ cryopreserved ulcer exudate using the rabbit model
Successful isolation of Treponema pallidum strains from patients’ cryopreserved ulcer exudate using the rabbit model Open
Clinical isolates of Treponema pallidum subspecies pallidum (T. pallidum) would facilitate study of prevalent strains. We describe the first successful rabbit propagation of T. pallidum from cryopreserved ulcer specimens. Fresh ulcer exuda…