Charles N. Pagel
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View article: Changes in concentrations of cytokines and markers of bone turnover in dairy cows during different stages of a production cycle
Changes in concentrations of cytokines and markers of bone turnover in dairy cows during different stages of a production cycle Open
Changes in bone metabolism occur to meet the varying demands for calcium during pregnancy and lactation. These changes are regulated locally and systemically by a variety of factors, including hormones, cytokines, chemokines, and growth fa…
View article: Effect of Casein Genetic Variants and Glycosylation on Rennet-Induced Coagulation Properties
Effect of Casein Genetic Variants and Glycosylation on Rennet-Induced Coagulation Properties Open
View article: Effect of casein genetic variants and glycosylation on bovine milk foaming properties
Effect of casein genetic variants and glycosylation on bovine milk foaming properties Open
The effects of κ‐casein (κ‐CN) and β‐casein (β‐CN) genetic variant and κ‐CN glycosylation degree (GD, low or high) on interfacial and foaming properties of bovine skim milk were investigated. No significant effect was measured for milks wi…
View article: Differences in bone turnover markers and injury risks between local and international horses: A Victorian Spring Racing Carnival study
Differences in bone turnover markers and injury risks between local and international horses: A Victorian Spring Racing Carnival study Open
Background Musculoskeletal injuries (MSI) are common in racehorses and have been of increasing concern in horses travelling internationally to compete. Understanding the differences in bone turnover between local horses and international h…
View article: Assessment of subchondral bone microdamage quantification using contrast‐enhanced imaging techniques
Assessment of subchondral bone microdamage quantification using contrast‐enhanced imaging techniques Open
Bone microdamage is common at subchondral bone (SCB) sites subjected to repeated high rate and magnitude of loading in the limbs of athletic animals and humans. Microdamage can affect the biomechanical behaviour of bone under physiological…
View article: Effect of composition, casein genetic variants and glycosylation degree on bovine milk whipping properties
Effect of composition, casein genetic variants and glycosylation degree on bovine milk whipping properties Open
This study investigated the individual and combined effects of ĸ-Casein (ĸ-CN; AA, AB, BB), β-Casein (β-CN; A1A1, A1A2, A2A2) and high and low ratios of glycosylated ĸ-CN to total ĸ-CN, referred to as the glycosylation degree (GD), on bovi…
View article: Reducing the prosthesis modulus by inclusion of an open space lattice improves osteogenic response in a sheep model of extraarticular defect
Reducing the prosthesis modulus by inclusion of an open space lattice improves osteogenic response in a sheep model of extraarticular defect Open
Introduction: Stress shielding is a common complication following endoprosthetic reconstruction surgery. The resulting periprosthetic osteopenia often manifests as catastrophic fractures and can significantly limit future treatment options…
View article: The Effects of Rib Biopsy on Performance Indices of Dairy Cattle
The Effects of Rib Biopsy on Performance Indices of Dairy Cattle Open
View article: Effect of a protease‐activated receptor‐2 antagonist (<scp>GB88</scp>) on inflammation‐related loss of alveolar bone in periodontal disease
Effect of a protease‐activated receptor‐2 antagonist (<span>GB88</span>) on inflammation‐related loss of alveolar bone in periodontal disease Open
Background and Objective Protease‐activated receptor‐2 (PAR 2 ), a pro‐inflammatory G‐protein coupled receptor, has been associated with pathogenesis of periodontitis and the resulting bone loss caused by oral pathogens, including the keys…
View article: The role of glycosylation in amyloid fibril formation of bovine κ-casein
The role of glycosylation in amyloid fibril formation of bovine κ-casein Open
View article: The effect of casein genetic variants, glycosylation and phosphorylation on bovine milk protein structure, technological properties, nutrition and product manufacture
The effect of casein genetic variants, glycosylation and phosphorylation on bovine milk protein structure, technological properties, nutrition and product manufacture Open
Whilst there are only four genes that encode caseins found in bovine milk, there is a vast array of naturally occurring variants of each protein arising from both genetic polymorphisms and post-translational modification. Effects of the di…
View article: Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Angiogenesis and Lung Pathology in a Sheep Model of Pulmonary Fibrosis
Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Angiogenesis and Lung Pathology in a Sheep Model of Pulmonary Fibrosis Open
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic lung disease characterized by excessive extracellular matrix (ECM) deposition in the parenchyma of the lung. Accompanying the fibrotic remodeling, dysregulated angiogenesis has b…
View article: Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6
Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6 Open
View article: Tetrathiomolybdate Treatment Attenuates Microvascular Remodeling in a Large Animal Model of Bleomycin Induced Pulmonary Fibrosis
Tetrathiomolybdate Treatment Attenuates Microvascular Remodeling in a Large Animal Model of Bleomycin Induced Pulmonary Fibrosis Open
View article: KCa3.1 channel blockade attenuates microvascular remodelling in a large animal model of bleomycin-induced pulmonary fibrosis
KCa3.1 channel blockade attenuates microvascular remodelling in a large animal model of bleomycin-induced pulmonary fibrosis Open
View article: Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells
Normal inflammation and regeneration of muscle following injury require osteopontin from both muscle and non-muscle cells Open
Osteopontins from muscle and non-muscle sources are equally important in the acute response of muscle to injury, and cannot substitute for each other, suggesting that they play distinct roles in regulation of cell behaviour. Future studies…
View article: Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease
Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease Open
Chronic periodontitis is characterised by gingival inflammation and alveolar bone loss. A major aetiological agent is Porphyromonas gingivalis, which secretes proteases that activate protease-activated receptor 2 (PAR2 ). PAR
View article: The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation
The vacuolar H+ ATPase V0 subunit d2 is associated with chondrocyte hypertrophy and supports chondrocyte differentiation Open
View article: The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts
The antiepileptic medications carbamazepine and phenytoin inhibit native sodium currents in murine osteoblasts Open
Summary Objective Fracture risk is a serious comorbidity in epilepsy and may relate to the use of antiepileptic drugs (AEDs). Many AEDs inhibit ion channel function, and the expression of these channels in osteoblasts raises the question o…
View article: Identification of novel osteochondrosis— Associated genes
Identification of novel osteochondrosis— Associated genes Open
During the early stages of articular osteochondrosis, cartilage is retained in subchondral bone, but the pathophysiology of this condition of growing humans and domestic animals is poorly understood. A subtractive hybridization study was u…