Bruce Neal
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View article: Cardiac Impact of Dapagliflozin in Advanced Chronic Kidney Disease: Rationale and Design of the Renal Lifecycle Trial Cardiac Imaging Sub-studies
Cardiac Impact of Dapagliflozin in Advanced Chronic Kidney Disease: Rationale and Design of the Renal Lifecycle Trial Cardiac Imaging Sub-studies Open
Background Patients with chronic kidney disease (CKD) are frequently hospitalized for heart failure. Sodium glucose co-transporter 2 (SGLT2)-inhibitors improve cardiorenal outcomes in CKD and heart failure, at least in estimated glomerular…
View article: Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study
Consistency of Blood Pressure Response to Potassium-Enriched Salt in the China Salt Substitute Study Open
BACKGROUND: Large between-person differences in blood pressure (BP) responses to sodium reduction, potassium supplementation, and potassium-enriched salt have been suggested by prior studies. However, limitations in research designs and mi…
View article: Dietary sources of sodium intake in nigerian adults: A population-based cross-sectional study
Dietary sources of sodium intake in nigerian adults: A population-based cross-sectional study Open
View article: Potassium-enriched salt for patients with hypertension: a Hypertension Australia and National Hypertension Taskforce of Australia Position Statement
Potassium-enriched salt for patients with hypertension: a Hypertension Australia and National Hypertension Taskforce of Australia Position Statement Open
Introduction: High blood pressure remains the leading risk factor for cardiovascular and all-cause deaths in Australia. Higher sodium and lower potassium intake are well established risk factors for elevated blood pressure and increased ca…
View article: Availability, healthiness and sodium content of packaged and unpackaged foods and beverages in nigeria: a cross-sectional study
Availability, healthiness and sodium content of packaged and unpackaged foods and beverages in nigeria: a cross-sectional study Open
View article: FGF-23, hsCRP, Cardiovascular Events, and the Benefit of Canagliflozin in the CANVAS Trial
FGF-23, hsCRP, Cardiovascular Events, and the Benefit of Canagliflozin in the CANVAS Trial Open
FGF-23 and hsCRP are biomarkers associated with increased CV risk, but these markers did not identify participants who preferentially benefited from treatment with canagliflozin.
View article: Potassium-enriched salt substitutes: supporting global cardiovascular and kidney health
Potassium-enriched salt substitutes: supporting global cardiovascular and kidney health Open
View article: Salt Supply Chain Practices and Technical Considerations for Switching to Potassium‐Enriched Salt Use in Australia: A Qualitative Study
Salt Supply Chain Practices and Technical Considerations for Switching to Potassium‐Enriched Salt Use in Australia: A Qualitative Study Open
Background : Switching to potassium‐enriched salt in food manufacturing and preparation is expected to lower blood pressure and improve stroke and cardiovascular disease outcomes. However, it is not well understood how the Australian salt …
View article: Evaluation of Population‐Based Sodium Reduction Strategies in China: Protocol for a Study Using a Combined Quantitative and Qualitative Approach
Evaluation of Population‐Based Sodium Reduction Strategies in China: Protocol for a Study Using a Combined Quantitative and Qualitative Approach Open
Sodium intake in China is among the highest in the world, particularly in rural areas. A government‐led national sodium reduction program has been implemented but evaluations of its implementation and effectiveness remain limited. The stud…
View article: Stakeholder perspectives on scaling up potassium-enriched salt to reduce cardiovascular disease in Australia: a qualitative study
Stakeholder perspectives on scaling up potassium-enriched salt to reduce cardiovascular disease in Australia: a qualitative study Open
View article: Statistical Analysis Plan (SAP): A randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: the CRAFT trial
Statistical Analysis Plan (SAP): A randomized controlled trial of intensive blood pressure control on cardiovascular risk reduction in patients with atrial fibrillation: the CRAFT trial Open
The CRAFT trial is designed to evaluate the effects of intensive blood pressure (BP) control in reducing cardiovascular (CV) risks in patients with atrial fibrillation (AF). The trial is a randomized controlled, open-label, parallel-group …
View article: A feasibility study for a trial testing the effects of reduced-sodium salt on the rise in blood pressure with age
A feasibility study for a trial testing the effects of reduced-sodium salt on the rise in blood pressure with age Open
NCT05912426.
View article: Dietary Sodium and Potassium Intake, Sources, and Salt-Related Knowledge, Attitude, and Behavior Among Rural Adults in Four Provinces of China: A Cross-Sectional Study
Dietary Sodium and Potassium Intake, Sources, and Salt-Related Knowledge, Attitude, and Behavior Among Rural Adults in Four Provinces of China: A Cross-Sectional Study Open
View article: Effect of sodium-reduced potassium-enriched salt substitutes on stomach cancer: the Salt Substitute and Stroke Study (SSaSS)
Effect of sodium-reduced potassium-enriched salt substitutes on stomach cancer: the Salt Substitute and Stroke Study (SSaSS) Open
This trial was registered in ClinicalTrials.gov as NCT02092090.
View article: Increasing potassium-enriched salt use in Australia—understanding the salt supply chain
Increasing potassium-enriched salt use in Australia—understanding the salt supply chain Open
Excess sodium consumption, mostly from dietary salt, causes high blood pressure and an increased risk of cardiovascular disease (1) . In parallel, insufficient potassium intake also contributes to raised blood pressure (2) . Switching regu…
View article: Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the <scp>CANVAS</scp> and <scp>CREDENCE</scp> trials
Canagliflozin reduces oral loop diuretic intensification in patients with type 2 diabetes: A participant‐level pooled analysis of the <span>CANVAS</span> and <span>CREDENCE</span> trials Open
Aims The sodium–glucose cotransporter 2 inhibitor canagliflozin reduces the risk of heart failure (HF) hospitalization or cardiovascular death and chronic kidney disease (CKD) progression among patients with type 2 diabetes at high cardiov…
View article: Single-centre, double-blinded, randomised placebo-controlled trial to determine the effect of a 12-week home-based programme of footplate neuromuscular electrical stimulation on walking capacity in people with peripheral artery disease: a protocol for the Foot-PAD trial
Single-centre, double-blinded, randomised placebo-controlled trial to determine the effect of a 12-week home-based programme of footplate neuromuscular electrical stimulation on walking capacity in people with peripheral artery disease: a protocol for the Foot-PAD trial Open
Introduction Patients with peripheral artery disease (PAD) can experience intermittent claudication, which limits walking capacity and the ability to undertake daily activities. While exercise therapy is an established way to improve walki…
View article: Effectiveness of an online food shopping intervention to reduce salt purchases among individuals with hypertension – findings of the SaltSwitch Online Grocery Shopping (OGS) randomised trial
Effectiveness of an online food shopping intervention to reduce salt purchases among individuals with hypertension – findings of the SaltSwitch Online Grocery Shopping (OGS) randomised trial Open
View article: The potential for reducing greenhouse gas emissions through disease prevention: a secondary analysis of data from the CREDENCE trial
The potential for reducing greenhouse gas emissions through disease prevention: a secondary analysis of data from the CREDENCE trial Open
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View article: Estimated health effect, cost, and cost-effectiveness of mandating sodium benchmarks in Australia's packaged foods: a modelling study
Estimated health effect, cost, and cost-effectiveness of mandating sodium benchmarks in Australia's packaged foods: a modelling study Open
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View article: Estimated health benefits, costs, and cost-effectiveness of implementing WHO's sodium benchmarks for packaged foods in India: a modelling study
Estimated health benefits, costs, and cost-effectiveness of implementing WHO's sodium benchmarks for packaged foods in India: a modelling study Open
View article: Health Claims, Product Features and Instructions for Use on the Labels of Potassium-enriched Salt Products: A Content Analysis
Health Claims, Product Features and Instructions for Use on the Labels of Potassium-enriched Salt Products: A Content Analysis Open
There was large variability in the label features of potassium-enriched salt products identified in this study. Most product labels made no health-related statements, but among those that did, warnings occurred more frequently than stateme…
View article: Canagliflozin and iron metabolism in the CREDENCE trial
Canagliflozin and iron metabolism in the CREDENCE trial Open
Background Studies in patients with heart failure have indicated that sodium-glucose cotransporter 2 (SGLT2) inhibitors increase iron use and enhance erythropoiesis. In this post hoc analysis of the Canagliflozin and Renal Endpoints in Dia…
View article: Effect of salt substitution on fracture—a secondary analysis of the Salt Substitute and Stroke Study (SSaSS)
Effect of salt substitution on fracture—a secondary analysis of the Salt Substitute and Stroke Study (SSaSS) Open
View article: Application of environmentally extended input-output data to estimate greenhouse gas emissions attributable to packaged foods and beverages in Australia
Application of environmentally extended input-output data to estimate greenhouse gas emissions attributable to packaged foods and beverages in Australia Open
Input-output tables for national economies are widely available and may provide an established mechanism for estimating environmental impacts of industry sectors. We used environmentally extended input-output (EEIO) analysis to estimate gr…
View article: Modifying the <scp>Health Star Rating</scp> nutrient profiling algorithm to account for ultra‐processing
Modifying the <span>Health Star Rating</span> nutrient profiling algorithm to account for ultra‐processing Open
Aim To modify the Australian and New Zealand Health Star Rating to account for ultra‐processing and compare the alignment of the modified ratings with NOVA classifications and the current Australian Dietary Guidelines classifications of co…
View article: Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: a SMART-C collaborative meta-analysis of randomised controlled trials
Efficacy and safety of SGLT2 inhibitors with and without glucagon-like peptide 1 receptor agonists: a SMART-C collaborative meta-analysis of randomised controlled trials Open
View article: Estimated Health Benefits, Costs, and Cost-Effectiveness of Implementing WHO Global Sodium Benchmarks in India
Estimated Health Benefits, Costs, and Cost-Effectiveness of Implementing WHO Global Sodium Benchmarks in India Open
View article: Effects of Price Subsidy and Health Education on Sales of Reduced-Sodium Potassium-Enriched Salt: A Cluster Factorial Trial
Effects of Price Subsidy and Health Education on Sales of Reduced-Sodium Potassium-Enriched Salt: A Cluster Factorial Trial Open
View article: Effects of canagliflozin on total heart failure events across the kidney function spectrum: Participant‐level pooled analysis from the <scp>CANVAS</scp> Program and <scp>CREDENCE</scp> trial
Effects of canagliflozin on total heart failure events across the kidney function spectrum: Participant‐level pooled analysis from the <span>CANVAS</span> Program and <span>CREDENCE</span> trial Open
Aims People with type 2 diabetes (T2D) face high risks of heart failure (HF) hospitalizations that are often recurrent, especially as kidney function declines. We examined the effects of canagliflozin on total HF events by baseline kidney …