Charles P. Lin
YOU?
Author Swipe
View article: Towards noninvasive white blood cell count
Towards noninvasive white blood cell count Open
Despite rapid advances in diagnostic and imaging technologies, no clinical device for noninvasive monitoring of the immune system is currently available. The standard white blood cell count (WBCC), a key clinical measure for assessing pati…
View article: Towards Non-Invasive White Blood Cell Count in Humans
Towards Non-Invasive White Blood Cell Count in Humans Open
Despite rapid advances in diagnostic and imaging technologies, a method for noninvasive monitoring of the immune system does not exist. The standard white blood cell count (WBCC), a key clinical measure for assessing patients’ health, requ…
View article: Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells
Transcripts of repetitive DNA elements signal to block phagocytosis of hematopoietic stem cells Open
Macrophages maintain hematopoietic stem cell (HSC) quality by assessing cell surface Calreticulin (Calr), an “eat-me” signal induced by reactive oxygen species (ROS). Using zebrafish genetics, we identified Beta-2-microglobulin (B2m) as a …
View article: Resilient anatomy and local plasticity of naive and stress haematopoiesis
Resilient anatomy and local plasticity of naive and stress haematopoiesis Open
View article: A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate
A mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate Open
View article: MACROPHAGES COORDINATE IMMUNE RESPONSE TO LASER-INDUCED INJURY VIA EXTRACELLULAR TRAPS
MACROPHAGES COORDINATE IMMUNE RESPONSE TO LASER-INDUCED INJURY VIA EXTRACELLULAR TRAPS Open
Macrophages/monocytes, the primary contributors to chronic inflammation in degenerated retinas, orchestrate intricate immune responses. They remain enigmatic in their local coordination and activation mechanisms. Innovations in experimenta…
View article: 149 Autofluorescence imaging allows label-free identification of all airway epithelial cell types and reveals the dynamic formation of airway secretory cell associated antigen passages
149 Autofluorescence imaging allows label-free identification of all airway epithelial cell types and reveals the dynamic formation of airway secretory cell associated antigen passages Open
View article: Miniaturized microscope for non-invasive imaging of leukocyte-endothelial interactions in human microcirculation
Miniaturized microscope for non-invasive imaging of leukocyte-endothelial interactions in human microcirculation Open
We present a miniature oblique back-illumination microscope (mOBM) for imaging the microcirculation of human oral mucosa, enabling real-time, label-free phase contrast imaging of leukocyte rolling and adhesion, the initial steps in leukocy…
View article: Table of Contents
Table of Contents Open
View article: Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis
Correction: Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis Open
View article: Data from <b><i>In Vivo</i></b> Flow Cytometry
Data from <b><i>In Vivo</i></b> Flow Cytometry Open
The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating ca…
View article: Supplementary Material from <b><i>In Vivo</i></b> Flow Cytometry
Supplementary Material from <b><i>In Vivo</i></b> Flow Cytometry Open
Video
View article: Supplementary Material from <b><i>In Vivo</i></b> Flow Cytometry
Supplementary Material from <b><i>In Vivo</i></b> Flow Cytometry Open
Video
View article: Data from <b><i>In Vivo</i></b> Flow Cytometry
Data from <b><i>In Vivo</i></b> Flow Cytometry Open
The fate of circulating tumor cells is an important determinant of their ability to form distant metastasis. Here, we demonstrate the use of in vivo flow cytometry as a powerful new method for detecting quantitatively circulating ca…
View article: Author response: Autofluorescence imaging permits label-free cell type assignment and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs)
Author response: Autofluorescence imaging permits label-free cell type assignment and reveals the dynamic formation of airway secretory cell associated antigen passages (SAPs) Open
Full text Figures and data Side by side Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abs…
View article: Label free autofluorescence imaging permits comprehensive and simultaneous assignment of cell type identity and reveals the existence of airway secretory cell associated antigen passages (SAPs)
Label free autofluorescence imaging permits comprehensive and simultaneous assignment of cell type identity and reveals the existence of airway secretory cell associated antigen passages (SAPs) Open
The specific functional properties of a tissue are distributed amongst its component cell types. The various cells act coherently, as an ensemble, in order to execute a properly orchestrated physiologic response. Thus, modern approaches to…
View article: Laser Micromachining of Bone as a Tool for Studying Bone Marrow Biology
Laser Micromachining of Bone as a Tool for Studying Bone Marrow Biology Open
View article: Thymic mesenchymal niche cells drive T cell immune regeneration
Thymic mesenchymal niche cells drive T cell immune regeneration Open
Thymic atrophy and the progressive immune decline that accompanies it is a major health problem, chronically with age and acutely with immune injury. No solution has been defined. Here we demonstrate that one of the three mesenchymal cell …
View article: Image-seq: spatially-resolved single cell sequencing guided by in situ and in vivo imaging
Image-seq: spatially-resolved single cell sequencing guided by in situ and in vivo imaging Open
Tissue function depends on proper cellular organization. While the properties of individual cells are increasingly being deciphered using powerful single-cell sequencing technologies, understanding their spatial organization and temporal e…
View article: Image-seq: A new technology for spatially-resolved single-cell RNA sequencing
Image-seq: A new technology for spatially-resolved single-cell RNA sequencing Open
Data and code used to produce the analysis in "Image-seq: A new technology for spatially-resolved single-cell RNA sequencing" by Christa et al. (2022). Here, we present Image-seq, a technology that provides single-cell transcriptional data…
View article: Memory-Based Model Editing at Scale
Memory-Based Model Editing at Scale Open
Even the largest neural networks make errors, and once-correct predictions can become invalid as the world changes. Model editors make local updates to the behavior of base (pre-trained) models to inject updated knowledge or correct undesi…
View article: A Randomized Trial of Topical Fibrinogen-Depleted Human Platelet Lysate Treatment of Dry Eye Secondary to Chronic Graft-versus-Host Disease
A Randomized Trial of Topical Fibrinogen-Depleted Human Platelet Lysate Treatment of Dry Eye Secondary to Chronic Graft-versus-Host Disease Open
Fibrinogen-depleted human platelet lysate appears to be well tolerated, with no significant toxicity at concentrations of 10% and 30%. These initial data suggest some efficacy, especially for subjective outcome measures relative to baselin…
View article: Publisher Correction: Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging
Publisher Correction: Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging Open
View article: Cross-sectional UHR-SD-OCT image stack (XZ, full resolution) of porcine left bundle branch fibers
Cross-sectional UHR-SD-OCT image stack (XZ, full resolution) of porcine left bundle branch fibers Open
Cross-sectional UHR-SD-OCT image stack (XZ, full resolution) of an area of the left ventricular outlet septum in a porcine heart immediately below the membranous septum and below the aortic valve (transition from membranous septum to condu…
View article: Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth
Proton export alkalinizes intracellular pH and reprograms carbon metabolism to drive normal and malignant cell growth Open
Proton export is often considered a detoxifying process in animal cells, with monocarboxylate symporters coexporting excessive lactate and protons during glycolysis or the Warburg effect. We report a novel mechanism by which lactate/H+ exp…
View article: Cerebrospinal fluid outflow through skull channels instructs cranial hematopoiesis
Cerebrospinal fluid outflow through skull channels instructs cranial hematopoiesis Open
Interactions between the immune and central nervous systems strongly influence brain health. Although the blood-brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border tissues, particularly dural ly…
View article: LASER: Learning a Latent Action Space for Efficient Reinforcement\n Learning
LASER: Learning a Latent Action Space for Efficient Reinforcement\n Learning Open
The process of learning a manipulation task depends strongly on the action\nspace used for exploration: posed in the incorrect action space, solving a task\nwith reinforcement learning can be drastically inefficient. Additionally,\nsimilar…
View article: Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin Open
Osteocytes use an elaborate network of dendritic connections to control bone remodeling. Some osteoblasts embed within mineralized bone matrix, change shape, and become osteocytes. The molecular circuitry that drives dendrite formation dur…
View article: Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging
Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging Open
The fate of hematopoietic stem cells (HSCs) in the bone marrow can be directed by microenvironmental factors including extracellular calcium ion concentration (T h can vary significantly with bone remodeling, but the local e around individ…
View article: Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML
Imaging dynamic mTORC1 pathway activity in vivo reveals marked shifts that support time-specific inhibitor therapy in AML Open