Charles R. Goodlett
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View article: Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice
Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice Open
Down syndrome (DS) is caused by the triplication of human chromosome 21 (Hsa21), resulting in skeletal insufficiency and altered bone development. DS mouse models recapitulate these deficits, including sexual dimorphism in long bone altera…
View article: Behavioral Phenotyping for Down Syndrome in Mice
Behavioral Phenotyping for Down Syndrome in Mice Open
Down syndrome (DS) is the most frequent genetic cause of intellectual disability, characterized by alterations in different behavioral symptom domains: neurodevelopment, motor behavior, and cognition. As mouse models have the potential to …
View article: Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice
Evaluation of the therapeutic potential of Epigallocatechin-3-gallate (EGCG) via oral gavage in young adult Down syndrome mice Open
Epigallocatechin-3-gallate (EGCG) is a candidate therapeutic for Down syndrome (DS) phenotypes based on in vitro inhibition of DYRK1A, a triplicated gene product of Trisomy 21 (Ts21). Consumption of green tea extracts containing EGCG impro…
View article: Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs
Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs Open
Fetal alcohol spectrum disorder (FASD) is a leading potentially preventable birth defect. Poor nutrition may contribute to adverse developmental outcomes of prenatal alcohol exposure, and supplementation of essential micronutrients such as…
View article: Additional file of Alteration of gene expression by alcohol exposure at early neurulation
Additional file of Alteration of gene expression by alcohol exposure at early neurulation Open
Additional file of Alteration of gene expression by alcohol exposure at early neurulation
View article: Additional file 1 of Alteration of gene expression by alcohol exposure at early neurulation
Additional file 1 of Alteration of gene expression by alcohol exposure at early neurulation Open
Additional file 1:Keyword and GO categories. List of keywords used and the GO categories identified by these key words for Early Development. (XLS 283 KB)
View article: Additional file of Alteration of gene expression by alcohol exposure at early neurulation
Additional file of Alteration of gene expression by alcohol exposure at early neurulation Open
Additional file of Alteration of gene expression by alcohol exposure at early neurulation
View article: Additional file of Alteration of gene expression by alcohol exposure at early neurulation
Additional file of Alteration of gene expression by alcohol exposure at early neurulation Open
Additional file of Alteration of gene expression by alcohol exposure at early neurulation
View article: Additional file 3 of Alteration of gene expression by alcohol exposure at early neurulation
Additional file 3 of Alteration of gene expression by alcohol exposure at early neurulation Open
Additional file 3:GO categories related to Stem Cells. Gene sets used in GSEA analysis based on GO categories related to Stem Cells. Title of each set followed by Entrez Gene Ids of the genes in the set. (XLS 39 KB)
View article: Additional file 2 of Alteration of gene expression by alcohol exposure at early neurulation
Additional file 2 of Alteration of gene expression by alcohol exposure at early neurulation Open
Additional file 2:GO gene sets selected by keywords. List of gene sets used in GSEA analyses, derived from GO categories selected by key words for Early Development. Title of each set followed by Entrez Gene Ids of the genes in the set. (X…
View article: Meta‐Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure?
Meta‐Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? Open
Background Externalizing disorders are heritable precursors to alcohol dependence, common in children of alcoholics ( COA ), and in children with prenatal alcohol exposure ( PAE ). Pregnancies involving alcohol exposure sufficient to affec…
View article: Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits
Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits Open
Overexpression of Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A), located on human chromosome 21, may alter molecular processes linked to developmental deficits in Down syndrome (DS). Trisomic DYRK1A is a rational th…
View article: Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs
Maternal choline supplementation in a sheep model of first trimester binge alcohol fails to protect against brain volume reductions in peripubertal lambs Open
Fetal alcohol spectrum disorder (FASD) is a leading potentially preventable birth defect. Poor nutrition may contribute to adverse developmental outcomes of prenatal alcohol exposure, and supplementation of essential micronutrients such as…