Charles R. Newton
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View article: Correction: Evaluation of the Psychometric Properties of the Social Communication Questionnaire in Rural Kenya
Correction: Evaluation of the Psychometric Properties of the Social Communication Questionnaire in Rural Kenya Open
View article: Acceptability, feasibility and preliminary evaluation of the WHO caregiver skills training for children with developmental disabilities in rural and urban Kenya
Acceptability, feasibility and preliminary evaluation of the WHO caregiver skills training for children with developmental disabilities in rural and urban Kenya Open
Background Interventions to improve the developmental outcomes of children with developmental disabilities (DDs) in low-resourced settings such as Kenya are limited. The WHO caregiver skills training (CST) was developed to address social a…
View article: A “Familiar Foe Revisited": Examining the Relationship between endemic Burkitt’s Lymphoma and Changing Malaria Admissions in The Coastal Region of Kenya
A “Familiar Foe Revisited": Examining the Relationship between endemic Burkitt’s Lymphoma and Changing Malaria Admissions in The Coastal Region of Kenya Open
Background Burkitt’s lymphoma (BL) is a type of non-Hodgkin lymphoma that may account for more than 40% of childhood malignancies in tropical Africa. The endemic version is common in equatorial Africa, where a BL belt has been mapped. The …
View article: Accounting for clustering for self-reported outcomes in the design and analysis of population-based surveys: A case study of estimation of prevalence of epilepsy in Nairobi, Kenya
Accounting for clustering for self-reported outcomes in the design and analysis of population-based surveys: A case study of estimation of prevalence of epilepsy in Nairobi, Kenya Open
Population-based surveys are common for estimation of important public health metrics such as prevalence. Often, survey data tend to have a hierarchical structure where households are clustered within villages or sites and interviewers are…
View article: High epilepsy prevalence and excess mortality in onchocerciasis-endemic counties of South Sudan: A call for integrated interventions
High epilepsy prevalence and excess mortality in onchocerciasis-endemic counties of South Sudan: A call for integrated interventions Open
Background Epilepsy is a major health concern in onchocerciasis-endemic regions with intense transmission, where the infection is associated with a high epilepsy burden. This study investigated epilepsy prevalence and mortality in five onc…
View article: The effect of impaired blood brain barrier in the response to anti-seizure medication in acute symptomatic seizures in severe falciparum malaria
The effect of impaired blood brain barrier in the response to anti-seizure medication in acute symptomatic seizures in severe falciparum malaria Open
Background Blood brain barrier disruption is documented in severe falciparum malaria, but the role of the cerebrospinal fluid (CSF) proteins on pathogenesis and control of acute symptomatic seizures is not studied. We hypothesized that ele…
View article: The relationship between lifetime trauma exposure and psychosis in a multi-country case-control study in Africa
The relationship between lifetime trauma exposure and psychosis in a multi-country case-control study in Africa Open
View article: Socio-medical factors associated with neurodevelopmental disorders on the Kenyan coast
Socio-medical factors associated with neurodevelopmental disorders on the Kenyan coast Open
Neurodevelopmental disorders (NDDs) are a group of conditions with their onset during the early developmental period and include conditions such as autism and intellectual disability. Occurrence of NDDs is thought to be determined by both …
View article: Sociodemographic influences on substance use in psychosis in an African cohort
Sociodemographic influences on substance use in psychosis in an African cohort Open
View article: Characterisation of febrile non-traumatic coma in sub-Saharan Africa
Characterisation of febrile non-traumatic coma in sub-Saharan Africa Open
View article: Correction: Evaluating the generalisability of region-naïve machine learning algorithms for the identification of epilepsy in low-resource settings
Correction: Evaluating the generalisability of region-naïve machine learning algorithms for the identification of epilepsy in low-resource settings Open
[This corrects the article DOI: 10.1371/journal.pdig.0000491.].
View article: Major depressive disorder in sub-Saharan Africa: findings from the Neuro-GAP-Psychosis study
Major depressive disorder in sub-Saharan Africa: findings from the Neuro-GAP-Psychosis study Open
Major depressive disorder (MDD) is a significant contributor to the burden of mental disorders in Africa, necessitating an understanding of its prevalence and risk factors across diverse socio-cultural contexts to address health disparitie…
View article: A multifaceted intervention to improve diagnosis and early management of hospitalised patients with suspected acute brain infections in Brazil, India, and Malawi: an international multicentre intervention study
A multifaceted intervention to improve diagnosis and early management of hospitalised patients with suspected acute brain infections in Brazil, India, and Malawi: an international multicentre intervention study Open
View article: Evaluating the generalisability of region-naïve machine learning algorithms for the identification of epilepsy in low-resource settings
Evaluating the generalisability of region-naïve machine learning algorithms for the identification of epilepsy in low-resource settings Open
Objectives Approximately 80% of people with epilepsy live in low- and middle-income countries (LMICs), where limited resources and stigma hinder accurate diagnosis and treatment. Clinical machine learning models have demonstrated substanti…
View article: Epilepsy in low- to middle-income countries
Epilepsy in low- to middle-income countries Open
Purpose of review Epilepsy disproportionately affects those in low- and middle-income countries (LMICs) where diagnostic and treatment gaps persist. We highlight key recent developments and showcase practical opportunities to improve epile…
View article: Risk of epilepsy following first unprovoked and acute seizures: Cohort study
Risk of epilepsy following first unprovoked and acute seizures: Cohort study Open
Objective First unprovoked seizures and acute seizures are common and can develop into epilepsy. The risk of epilepsy following these seizures in community samples is not well established, and it is unclear whether the probability of subse…
View article: Translation, adaptation and validation of an epilepsy screening instrument in two Ghanaian languages
Translation, adaptation and validation of an epilepsy screening instrument in two Ghanaian languages Open
Introduction The prevalence of epilepsy in sub-Saharan Africa varies considerably, and the exact estimate for Ghana remains unclear, particularly in peri-urban areas where data are scarce. More community-based studies are required to under…
View article: Modeling the determinants of attrition in a two-stage epilepsy prevalence survey in Nairobi using machine learning
Modeling the determinants of attrition in a two-stage epilepsy prevalence survey in Nairobi using machine learning Open
View article: Major Depressive Disorder in Sub-Saharan Africa: Findings from the Neuro-Gap-Psychosis Study
Major Depressive Disorder in Sub-Saharan Africa: Findings from the Neuro-Gap-Psychosis Study Open
View article: Validity and reliability of the Mini International Neuropsychiatric Interview in Sub-Saharan Africa: a cross-country comparison study
Validity and reliability of the Mini International Neuropsychiatric Interview in Sub-Saharan Africa: a cross-country comparison study Open
Background Diagnostic tools, such as the Mini International Neuropsychiatric Interview (MINI) 7.0.2 and the Structured Clinical Interview for the DSM-5 (SCID), aim to increase the validity and reliability of diagnostic assessment. However,…
View article: Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: a cohort study
Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: a cohort study Open
The objective of this study was to investigate the impact of common mental disorder (CMD; depression/anxiety) symptoms and risky substance use in people with epilepsy in Ethiopia (four districts) on quality of life (QoL) and functioning ov…
View article: Evaluating Utility of Machine Learning-Based Imputation Methods to Account for Attrition in Multi-Stage Epilepsy Prevalence Surveys
Evaluating Utility of Machine Learning-Based Imputation Methods to Account for Attrition in Multi-Stage Epilepsy Prevalence Surveys Open
View article: Contextualization and adaptation of the child and adolescent mental and behavioural disorders module of the mhGAP-IG in Kilifi and Nairobi counties in Kenya
Contextualization and adaptation of the child and adolescent mental and behavioural disorders module of the mhGAP-IG in Kilifi and Nairobi counties in Kenya Open
The Mental Health Gap Action Programme Intervention Guide (mhGAP-IG) was developed by the World Health Organization as a key tool for delivering evidence-based mental healthcare in non-specialized settings. The mhGAP-IG requires contextual…
View article: Experience and perceptions of mental ill-health in people with epilepsy in rural Ethiopia: A qualitative study
Experience and perceptions of mental ill-health in people with epilepsy in rural Ethiopia: A qualitative study Open
Introduction Understanding the lived experience of mental health and illness in people with epilepsy has been little investigated in Africa and yet is essential to inform person-centered care. The aim of this study was to explore the exper…
View article: The association of polytherapy and psychiatric comorbidity in epilepsy
The association of polytherapy and psychiatric comorbidity in epilepsy Open
View article: Prevalence of epilepsy: a population-based cohort study in Denmark with comparison to Global Burden of Disease (GBD) prevalence estimates
Prevalence of epilepsy: a population-based cohort study in Denmark with comparison to Global Burden of Disease (GBD) prevalence estimates Open
Background The Global Burden of Disease Study (GBD) produces prevalence estimates for ‘idiopathic epilepsy’ (ie, of unknown aetiology) and ‘secondary epilepsy’ (ie, with known aetiology) but does not report prevalence by underlying aetiolo…
View article: A digital dashboard for reporting mental, neurological and substance use disorders in Nairobi, Kenya: Implementing an open source data technology for improving data capture
A digital dashboard for reporting mental, neurological and substance use disorders in Nairobi, Kenya: Implementing an open source data technology for improving data capture Open
The availability of quality and timely data for routine monitoring of mental, neurological and substance use (MNS) disorders is a challenge, particularly in Africa. We assessed the feasibility of using an open-source data science technolog…
View article: Exploring psychotic symptoms among substance-naïve individuals and recent abstainers without a psychosis diagnosis: A cross-country study across Kenya, Uganda, Ethiopia, and South Africa
Exploring psychotic symptoms among substance-naïve individuals and recent abstainers without a psychosis diagnosis: A cross-country study across Kenya, Uganda, Ethiopia, and South Africa Open
View article: Supporting African communities to increase resilience and mental health of kids with developmental disabilities and their caregivers using the World Health Organization’s Caregiver Skills Training Programme (SPARK trial): study protocol for a cluster randomised clinical controlled trial
Supporting African communities to increase resilience and mental health of kids with developmental disabilities and their caregivers using the World Health Organization’s Caregiver Skills Training Programme (SPARK trial): study protocol for a cluster randomised clinical controlled trial Open
Background Most children with developmental disabilities (DD) live in low- and middle-income countries, but access to services is limited, impacting their ability to thrive. Pilot study findings of the World Health Organization’s Caregiver…
View article: Psychological Distress Among Ethnically Diverse Participants From Eastern and Southern Africa
Psychological Distress Among Ethnically Diverse Participants From Eastern and Southern Africa Open
Importance Psychological distress is characterized by anxiety and depressive symptoms. Although prior research has investigated the occurrence and factors associated with psychological distress in low- and middle-income countries, includin…