Charles W. Goss
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View article: Strategies to improve healthcare team communication structure and quality in resource-variable childhood cancer hospitals (TeamTalk): a study protocol
Strategies to improve healthcare team communication structure and quality in resource-variable childhood cancer hospitals (TeamTalk): a study protocol Open
Background Healthcare team communication is essential to high-quality childhood cancer care, especially during high-acuity events such as clinical deterioration and in resource-variable settings, where supportive interventions to resolve d…
View article: Multicenter Validation of a Machine Learning Model for Surgical Transfusion Risk at 45 US Hospitals
Multicenter Validation of a Machine Learning Model for Surgical Transfusion Risk at 45 US Hospitals Open
Importance Accurate estimation of surgical transfusion risk is important for perioperative planning and effective resource allocation. Most machine learning models in health care are not validated or perform poorly in external settings. Ob…
View article: 39 | IMPACT OF TIME OF ONSET ON POST‐TRANSPLANT LYMPHOPROLIFERATIVE DISORDER (PTLD) OUTCOMES: RESULTS FROM A PROSPECTIVE/RETROSPECTIVE MULTICENTER STUDY
39 | IMPACT OF TIME OF ONSET ON POST‐TRANSPLANT LYMPHOPROLIFERATIVE DISORDER (PTLD) OUTCOMES: RESULTS FROM A PROSPECTIVE/RETROSPECTIVE MULTICENTER STUDY Open
View article: NutriConnect: Enhancing Health and Food Security through Sustainable Solutions and Partnerships: Design and Protocol of a Pragmatic Comparative Effectiveness Trial
NutriConnect: Enhancing Health and Food Security through Sustainable Solutions and Partnerships: Design and Protocol of a Pragmatic Comparative Effectiveness Trial Open
Background Food insecurity and poor dietary intake contribute to health disparities, particularly among socioeconomically disadvantaged populations. Produce prescription programs aim to improve access to fruits and vegetables (F&V) for tho…
View article: A Customizable Data Quality Tool for Global Observational Research Networks
A Customizable Data Quality Tool for Global Observational Research Networks Open
Evaluating data quality is essential when combining multi-site observational clinical data for analysis. We collaborated with five research networks, representing various data approaches and workflows, to generalize an established data qua…
View article: When the parts are greater than the whole: how understanding mechanisms can advance implementation research
When the parts are greater than the whole: how understanding mechanisms can advance implementation research Open
View article: WCN25-2931 pOKRA Study: Biomarker-Based Diagnosis and Histological Correlation of Allograft Rejection in Pediatric Kidney Transplantation
WCN25-2931 pOKRA Study: Biomarker-Based Diagnosis and Histological Correlation of Allograft Rejection in Pediatric Kidney Transplantation Open
View article: Nutriconnect: Enhancing Health and Food Security Through Sustainable Solutions and Partnerships: Design and Protocol of a Pragmatic Comparative Effectiveness Trial
Nutriconnect: Enhancing Health and Food Security Through Sustainable Solutions and Partnerships: Design and Protocol of a Pragmatic Comparative Effectiveness Trial Open
View article: Effect of a multicomponent, person-centred care intervention on client experience and HIV treatment outcomes in Zambia: a stepped-wedge, cluster-randomised trial
Effect of a multicomponent, person-centred care intervention on client experience and HIV treatment outcomes in Zambia: a stepped-wedge, cluster-randomised trial Open
View article: Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival.
Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival. Open
In a new respiratory virus pandemic, optimizing allocation of scarce medical resources becomes an urgent challenge. Infection prognosis takes on particular importance when allocating scarce antiviral antibodies and drugs, which are most ef…
View article: The Post-transplant Lymphoproliferative Disorders—Metagenomic Shotgun Microbial Sequencing (PTLD-MSMS) Study Methods and Protocol
The Post-transplant Lymphoproliferative Disorders—Metagenomic Shotgun Microbial Sequencing (PTLD-MSMS) Study Methods and Protocol Open
Post-transplant lymphoproliferative disorders (PTLDs) remain a feared complication of transplantation, with significant morbidity and mortality. The oncogenic Epstein-Barr virus (EBV) is a key pathogenic driver in 50%–80% of cases. Numerou…
View article: Factors associated with never treatment and acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana, 2021
Factors associated with never treatment and acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana, 2021 Open
Guyana remains one of four countries in the Americas endemic for lymphatic filariasis (LF). Elimination of LF requires repeated annual mass drug administration (MDA) with sufficient levels of coverage for success. This study assesses the a…
View article: Moxidectin Plus Albendazole for Lymphatic Filariasis: An Open Label, Observer-Blinded, Randomized Controlled Trial
Moxidectin Plus Albendazole for Lymphatic Filariasis: An Open Label, Observer-Blinded, Randomized Controlled Trial Open
View article: Planning for the End at the Beginning: A Lesson in Sharing Research Findings of a Community-based COVID-19 Seroprevalence Survey
Planning for the End at the Beginning: A Lesson in Sharing Research Findings of a Community-based COVID-19 Seroprevalence Survey Open
Introduction Sharing research findings with participants is important but challenging. We evaluated a plan to share findings with participants of a COVID-19 seroprevalence project. Methods An electronic survey was distributed to participan…
View article: Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study
Behavioral Mechanisms That Mediate Mental and Physical Health Improvements in People With Chronic Pain Who Receive a Digital Health Intervention: Prospective Cohort Pilot Study Open
Background Preliminary evidence suggests that digital mental health intervention (Wysa for Chronic Pain) can improve mental and physical health in people with chronic musculoskeletal pain and coexisting symptoms of depression or anxiety. H…
View article: Antigen-specific CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans
Antigen-specific CD4+ T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans Open
View article: Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer’s and coronary disease pathways
Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer’s and coronary disease pathways Open
View article: Additional file 1 of Instrumental variables for implementation science: exploring context-dependent causal pathways between implementation strategies and evidence-based interventions
Additional file 1 of Instrumental variables for implementation science: exploring context-dependent causal pathways between implementation strategies and evidence-based interventions Open
Additional file 1.
View article: The salivary and nasopharyngeal microbiomes are associated with SARS‐CoV‐2 infection and disease severity
The salivary and nasopharyngeal microbiomes are associated with SARS‐CoV‐2 infection and disease severity Open
Emerging evidence suggests the oral and upper respiratory microbiota may play important roles in modulating host immune responses to viral infection. As the host microbiome may be involved in the pathophysiology of coronavirus disease 2019…
View article: Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples
Immune phenotypes that are associated with subsequent COVID-19 severity inferred from post-recovery samples Open
Severe COVID-19 causes profound immune perturbations, but pre-infection immune signatures contributing to severe COVID-19 remain unknown. Genome-wide association studies (GWAS) identified strong associations between severe disease and seve…
View article: Longitudinal Evaluation of Donor-Derived Cellfree DNA in Pediatric Kidney Transplantation
Longitudinal Evaluation of Donor-Derived Cellfree DNA in Pediatric Kidney Transplantation Open
Background and objectives Donor-derived cellfree DNA (cfDNA) is a less-invasive marker of allograft injury compared with kidney biopsy. However, donor-derived cfDNA has not yet been extensively tested in children, where the test may have d…
View article: Employment Loss and Food Insecurity — Race and Sex Disparities in the Context of COVID-19
Employment Loss and Food Insecurity — Race and Sex Disparities in the Context of COVID-19 Open
Black women faced the highest odds of employment loss and food insecurity, highlighting the disproportionate impact of COVID-19 among people with intersectional disadvantages of being both Black and female. Interventions to reduce employme…
View article: Risk Factors for Nontuberculous Mycobacteria Infections in Solid Organ Transplant Recipients: A Multinational Case-Control Study
Risk Factors for Nontuberculous Mycobacteria Infections in Solid Organ Transplant Recipients: A Multinational Case-Control Study Open
Background Risk factors for nontuberculous mycobacteria (NTM) infections after solid organ transplant (SOT) are not well characterized. Here we aimed to describe these factors. Methods Retrospective, multinational, 1:2 matched case-control…
View article: Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer and coronary disease pathways
Plasma proteomics of SARS-CoV-2 infection and severity reveals impact on Alzheimer and coronary disease pathways Open
Identification of the plasma proteomic changes of Coronavirus disease 2019 (COVID-19) is essential to understanding the pathophysiology of the disease and developing predictive models and novel therapeutics. We performed plasma deep proteo…
View article: The nasopharyngeal and salivary microbiomes in COVID‐19 patients with and without asthma
The nasopharyngeal and salivary microbiomes in COVID‐19 patients with and without asthma Open
So far, our understanding of the associations between respiratory infections and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the context of asthma is limited. Although our previous study and others did not find a correl…
View article: The salivary and nasopharyngeal microbiomes are associated with SARS-CoV-2 infection and disease severity
The salivary and nasopharyngeal microbiomes are associated with SARS-CoV-2 infection and disease severity Open
Oral and upper respiratory microbiota play important roles in modulating host immune responses to viral infection. As emerging evidence suggests the host microbiome may be involved in the pathophysiology of COVID-19, we aimed to investigat…
View article: Outcomes Analyses of Pediatric Acute Liver Failure Subjects Listed for Liver Transplantation
Outcomes Analyses of Pediatric Acute Liver Failure Subjects Listed for Liver Transplantation Open
Background: We characterized recent outcomes in US pediatric acute liver failure (PALF) subjects listed for liver transplantation (LT) using the Scientific Registry of Transplant Recipients (SRTR) database. Methods: Pediatric subjects list…
View article: Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia
Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia Open
We assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-…
View article: Assessment of the impact of the COVID-19 pandemic on health services use
Assessment of the impact of the COVID-19 pandemic on health services use Open
View article: Immune phenotypes that predict COVID-19 severity
Immune phenotypes that predict COVID-19 severity Open