Charles Y.F. Young
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View article: Across the professional lifespan: comparing the workforce trends of early career and established counselling psychologists in South Africa
Across the professional lifespan: comparing the workforce trends of early career and established counselling psychologists in South Africa Open
Counselling Psychologists (CPs) constitute a considerable proportion of psychologists in South Africa (SA), yet empirical knowledge on this workforce remains limited. Furthermore, changes within this workforce overtime have not been thorou…
View article: The dose–effect relationship in PTSD: the South African Constitutional Court Case of <i>AK v. Minister of Police</i> (2022)
The dose–effect relationship in PTSD: the South African Constitutional Court Case of <i>AK v. Minister of Police</i> (2022) Open
The decision of the South African Constitutional Court in AK v. Minister of Police has implications for law enforcement agencies that fail the victims of crime. In this matter, the plaintiff sued the Minister and others for damages after o…
View article: The gendered context of women charged with violent offences in the forensic psychiatric setting
The gendered context of women charged with violent offences in the forensic psychiatric setting Open
This study highlights the nature and context of violent offending by women referred for forensic psychiatric assessment in South Africa.
View article: ‘Crushed all over again’: the professional experiences of early career counselling psychologists in South Africa
‘Crushed all over again’: the professional experiences of early career counselling psychologists in South Africa Open
Counselling psychology in South Africa has recently emerged from a tumultuous period, stemming from regulatory efforts in 2011, which negatively impacted on the profession’s status and viability. While the definition and scope of counselli…
View article: Supplementary Figure 3 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 3 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 79K, Mass spectrometric analysis of SENL fractions 2, 3, and 4 obtained from HPLC. The total ion chromatogram retention time and the mass spectrum of individual peaks for the fractions 2, 3, and 4 are depicted in the panel A to C, re…
View article: Supplementary Figure 7 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 7 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 103K, Molecular structures for the compounds shown in the mass spectrum are depicted.
View article: Supplementary Figure 1 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 1 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 113K, Fractionation of SENL was performed using a Kinetex C18 column on a Shimadzu HPLC system. The experiments were performed in triplicate; a representative HPLC chromatogram of SENL is shown.
View article: Data from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Data from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
Azadirachta indica, commonly known as neem, has gained worldwide prominence because of its medical properties, namely antitumor, antiviral, anti-inflammatory, antihyperglycemic, antifungal, and antibacterial activities. Despite these promi…
View article: Supplementary Figure 8 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 8 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 89K, HPLC and Mass spectrometric analysis of mice plasma and tumor tissues for the bioavailability of SENL compounds after oral administration of SENL, 200 mg/kg body weight. A, HPLC chromatogram of plasma of mice treated with SENL. …
View article: Supplementary Figure Legends from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure Legends from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 71K, Legends to Supplementary Figures 1 through 8.
View article: Supplementary Figure 7 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 7 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 103K, Molecular structures for the compounds shown in the mass spectrum are depicted.
View article: Supplementary Figure 2 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 2 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 185K, The peaks labeled in the HPLC chromatogram were evaluated for cytotoxic activity against PC3 cells. The fractions collected from HPLC were concentrated using SpeedVac at 4 degrees C, and equal weights of the fractions were reco…
View article: Supplementary Figure 2 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 2 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 185K, The peaks labeled in the HPLC chromatogram were evaluated for cytotoxic activity against PC3 cells. The fractions collected from HPLC were concentrated using SpeedVac at 4 degrees C, and equal weights of the fractions were reco…
View article: Supplementary Figure 8 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 8 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 89K, HPLC and Mass spectrometric analysis of mice plasma and tumor tissues for the bioavailability of SENL compounds after oral administration of SENL, 200 mg/kg body weight. A, HPLC chromatogram of plasma of mice treated with SENL. …
View article: Supplementary Figure 6 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 6 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 46K, Mass spectrometric analysis of SENL fraction 14 obtained from HPLC and the standards nimbolide and 2′, 3′-dehydrosalannol. The total ion chromatogram retention time and the mass spectrum of individual peaks are depicted in the p…
View article: Supplementary Figure 3 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 3 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 79K, Mass spectrometric analysis of SENL fractions 2, 3, and 4 obtained from HPLC. The total ion chromatogram retention time and the mass spectrum of individual peaks for the fractions 2, 3, and 4 are depicted in the panel A to C, re…
View article: Supplementary Figure 5 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 5 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 64K, Mass spectrometric analysis of SENL fractions 9, 11, and 12 obtained from HPLC. The total ion chromatogram retention time and the mass spectrum of individual peaks for the fractions 9, 11, and 12 are depicted in the panel A to C…
View article: Supplementary Figure 4 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 4 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 69K, Mass spectrometric analysis of SENL fractions 5, 6, and 7 obtained from HPLC. The total ion chromatogram retention time and the mass spectrum of individual peaks for the fractions 5, 6, and 7 are depicted in the panel A to C, re…
View article: Supplementary Figure 4 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 4 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 69K, Mass spectrometric analysis of SENL fractions 5, 6, and 7 obtained from HPLC. The total ion chromatogram retention time and the mass spectrum of individual peaks for the fractions 5, 6, and 7 are depicted in the panel A to C, re…
View article: Supplementary Figure 6 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 6 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 46K, Mass spectrometric analysis of SENL fraction 14 obtained from HPLC and the standards nimbolide and 2′, 3′-dehydrosalannol. The total ion chromatogram retention time and the mass spectrum of individual peaks are depicted in the p…
View article: Supplementary Figure 5 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 5 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 64K, Mass spectrometric analysis of SENL fractions 9, 11, and 12 obtained from HPLC. The total ion chromatogram retention time and the mass spectrum of individual peaks for the fractions 9, 11, and 12 are depicted in the panel A to C…
View article: Supplementary Figure 1 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure 1 from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 113K, Fractionation of SENL was performed using a Kinetex C18 column on a Shimadzu HPLC system. The experiments were performed in triplicate; a representative HPLC chromatogram of SENL is shown.
View article: Data from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Data from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
Azadirachta indica, commonly known as neem, has gained worldwide prominence because of its medical properties, namely antitumor, antiviral, anti-inflammatory, antihyperglycemic, antifungal, and antibacterial activities. Despite these promi…
View article: Supplementary Figure Legends from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth
Supplementary Figure Legends from Preclinical Evaluation of the Supercritical Extract of <i>Azadirachta Indica</i> (Neem) Leaves <i>In Vitro</i> and <i>In Vivo</i> on Inhibition of Prostate Cancer Tumor Growth Open
PDF - 71K, Legends to Supplementary Figures 1 through 8.
View article: Supplementary Table 4B from Global Methylation Profiling for Risk Prediction of Prostate Cancer
Supplementary Table 4B from Global Methylation Profiling for Risk Prediction of Prostate Cancer Open
PDF file - 273K, Significance of methylation in prostate cancer tissue samples from 4 microarrays with the batch effect
View article: Supplementary Table 4D from Global Methylation Profiling for Risk Prediction of Prostate Cancer
Supplementary Table 4D from Global Methylation Profiling for Risk Prediction of Prostate Cancer Open
PDF file - 267K, Significance of methylation in prostate cancer tissue samples from 4 microarrays with the batch effect
View article: Data from EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance
Data from EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance Open
Aberrant activation of the androgen receptor (AR) by the ErbB2/ErbB3 heterodimer contributes to the development of hormone resistance in prostate cancer. EBP1, an ErbB3-binding protein, acts as an AR corepressor. As EBP1 is decreased in pr…
View article: Supplementary Table 2 from Global Methylation Profiling for Risk Prediction of Prostate Cancer
Supplementary Table 2 from Global Methylation Profiling for Risk Prediction of Prostate Cancer Open
XLS file - 34K, Most significantly methylated genes associated with prostate cancer recurrence from the Cox univariate analysis