Charley Cai
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View article: A Globally Representative Immunopeptidomics Approach to Identify Population-Wide Vaccine Candidates
A Globally Representative Immunopeptidomics Approach to Identify Population-Wide Vaccine Candidates Open
Vaccine development has historically relied on preclinical testing using one or two cell lines, typically of Caucasian descent, contributing to vaccines that may fail to provide adequate protection across genetically diverse populations. A…
View article: A novel sorting method for the enrichment of early human spermatocytes from clinical biopsies
A novel sorting method for the enrichment of early human spermatocytes from clinical biopsies Open
This work shows that TSP50 can be used to enrich early STRA8-expressing spermatocytes from human testicular biopsies, providing a means for targeted single-cell RNA sequencing analysis and in vitro functional interrogation of germ cells du…
View article: Rhodnius prolixus uses the peptidoglycan recognition receptor rpPGRP-LC/LA to detect Gram-negative bacteria and activate the IMD pathway
Rhodnius prolixus uses the peptidoglycan recognition receptor rpPGRP-LC/LA to detect Gram-negative bacteria and activate the IMD pathway Open
Insects rely on an innate immune system to recognize and eliminate pathogens. Key components of this system are highly conserved across all invertebrates. To detect pathogens, insects use Pattern recognition receptors (PRRs) that bind to s…