Charlie Changli Xue
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View article: Cardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence
Cardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence Open
Introduction There is considerable potential for using Chinese Herbal Medicine to manage inflammatory co-morbidities, including cardiovascular disease, in people with HIV. However, any use would require understanding herb–drug interactions…
View article: Photothermal Hydrogel with Mn <sub>3</sub> O <sub>4</sub> Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism
Photothermal Hydrogel with Mn <sub>3</sub> O <sub>4</sub> Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism Open
Annulus fibrosus (AF) injury plays a critical role in intervertebral disc degeneration (IVDD), with oxidative stress and extracellular matrix (ECM) imbalance being major pathogenic factors. However, effective repair methods are limited. In…
View article: Self‐Propelled Bacteria‐Mediated In Situ Biosynthesis of MnS Nanoparticles for Remodeling Tumor Microenvironment to Amplify cGAS‐STING Pathway for Antitumor Immunity
Self‐Propelled Bacteria‐Mediated In Situ Biosynthesis of MnS Nanoparticles for Remodeling Tumor Microenvironment to Amplify cGAS‐STING Pathway for Antitumor Immunity Open
cGAS‐STING pathway, an important innate immune signaling pathway, has attracted extensive attention in anti‐tumor immunotherapy research. However, the limited delivery ratio of STING agonists and lactate‐induced lactylation present signifi…
View article: Chinese herbal medicines for rhinosinusitis: a text-mining study with comparisons to contemporary research and clinical guidance
Chinese herbal medicines for rhinosinusitis: a text-mining study with comparisons to contemporary research and clinical guidance Open
Results for classical interventions and the modern clinical literature overlapped for the higher frequency oral formulae and their ingredients, showing evidence of temporal continuity in their use for rhinosinusitis management. Gaps in the…
View article: Vitamin D for primary dysmenorrhea and endometriosis-related pain – A systematic review of registered RCTs
Vitamin D for primary dysmenorrhea and endometriosis-related pain – A systematic review of registered RCTs Open
Objective This systematic review investigates the potential role of vitamin D supplement in alleviating pain associated with primary dysmenorrhea or endometriosis by analysing registered randomised controlled trials (RCTs). Methods We comp…
View article: Effects of Chinese herbal medicine on colorectal adenoma recurrence following polypectomy: a systematic review and meta-analysis
Effects of Chinese herbal medicine on colorectal adenoma recurrence following polypectomy: a systematic review and meta-analysis Open
Objective Preventing colorectal adenoma (CRA) recurrence after polypectomy is essential. However, the current evidence of Chinese herbal medicine (CHM) for CRA recurrence is still limited. This study aims to synthesize the effects of CHM a…
View article: Phenolic Acid and Flavonoid Content Analysis with Antioxidant Activity Assessment in Chinese C. pi. Shen Honey
Phenolic Acid and Flavonoid Content Analysis with Antioxidant Activity Assessment in Chinese C. pi. Shen Honey Open
The nutritional value of honey is closely related to its components, which are highly influenced by the botanic origin. C. pi. Shen (Codonopsis pilosula (Franch.) var. modesta (Nannf.) L. T. Shen), a key plant in traditional Chinese medici…
View article: Chinese herbal medicine for dyspnea and persistent symptoms of long COVID: A systematic review and meta-analysis of randomized controlled trials
Chinese herbal medicine for dyspnea and persistent symptoms of long COVID: A systematic review and meta-analysis of randomized controlled trials Open
CHM is associated with a post-treatment clinical reduction in depression and anxiety in long COVID adults, compared to the control, but it does not have a strong treatment effect on dyspnea and insomnia. Effects of CHM on exercise intolera…
View article: Chinese Herbal Medicine for Atopic Dermatitis: A Systematic Review of Registered Randomised Controlled Trials
Chinese Herbal Medicine for Atopic Dermatitis: A Systematic Review of Registered Randomised Controlled Trials Open
Background and Purpose: Many people with atopic dermatitis seek treatment with Chinese herbal medicine (CHM). However, the evidence that informed clinical guideline recommendations is outdated. This research updates the evidence on the eff…
View article: Oral Chinese herbal medicine combined with donepezil for mild cognitive impairment: A systematic review and meta‐analysis
Oral Chinese herbal medicine combined with donepezil for mild cognitive impairment: A systematic review and meta‐analysis Open
Background This study aims to evaluate the add‐on effects of oral Chinese herbal medicine (CHM) for mild cognitive impairment (MCI), when used in addition to donepezil compared to donepezil alone. Methods Randomized controlled trials compa…
View article: Renal protective effects and mechanisms of Astragalus membranaceus for diabetic kidney disease in animal models: An updated systematic review and meta-analysis
Renal protective effects and mechanisms of Astragalus membranaceus for diabetic kidney disease in animal models: An updated systematic review and meta-analysis Open
Astragalus membranaceus (AM) shows potential therapeutic benefits for managing diabetic kidney disease (DKD), a leading cause of kidney failure with no cure. However, its comprehensive effects on renal outcomes and plausible mechanisms rem…
View article: Add-on effects of Chinese herbal medicine external application (FZHFZY) to topical urea for mild-to-moderate psoriasis vulgaris: Protocol for a double-blinded randomized controlled pilot trial embedded with a qualitative study
Add-on effects of Chinese herbal medicine external application (FZHFZY) to topical urea for mild-to-moderate psoriasis vulgaris: Protocol for a double-blinded randomized controlled pilot trial embedded with a qualitative study Open
Psoriasis vulgaris is a chronic dermatological disease with a high global prevalence. It significantly reduces patients’ quality of life and is associated with a substantial economic burden. Conventional therapies for mild-to-moderate psor…
View article: The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trials
The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trials Open
Objective: Effective and safe treatments for mild cognitive impairment (MCI) are limited. Chinese herbal medicine (CHM) is commonly used in China to manage MCI. However, its efficacy and safety remain uncertain. This review aims to evaluat…
View article: Oral Chinese Herbal Medicine plus usual care for diabetic kidney disease: study protocol for a randomized, double-blind, placebo-controlled pilot trial
Oral Chinese Herbal Medicine plus usual care for diabetic kidney disease: study protocol for a randomized, double-blind, placebo-controlled pilot trial Open
Background Diabetic kidney disease (DKD) has become the leading cause of kidney failure, causing a significant socioeconomic burden worldwide. The usual care for DKD fails to achieve satisfactory effects in delaying the persistent loss of …
View article: Real-world observations and impacts of Chinese herbal medicine for migraine: results of a registry-based cohort study
Real-world observations and impacts of Chinese herbal medicine for migraine: results of a registry-based cohort study Open
Background: Migraine is a prevalent, recurrent condition with substantial disease burden. Chinese herbal medicine (CHM) has been used frequently for migraine in controlled clinical settings. This study is to summarise the characteristics o…
View article: Renal-protective effects of Chinese medicinal herbs and compounds for diabetic kidney disease in animal models: protocol for systematic review and meta-analysis
Renal-protective effects of Chinese medicinal herbs and compounds for diabetic kidney disease in animal models: protocol for systematic review and meta-analysis Open
View article: Does Chinese herbal medicine (CHM) reduce colorectal adenoma (CRA) recurrence: protocol of a registry-based, cohort study and a qualitative interview
Does Chinese herbal medicine (CHM) reduce colorectal adenoma (CRA) recurrence: protocol of a registry-based, cohort study and a qualitative interview Open
Introduction Colorectal adenoma (CRA) is a precancerous lesion for colorectal cancer. Endoscopic resection is the first-line treatment for CRA. However, CRA recurrence rate is high. This proposed study aims to determine if Chinese herbal m…
View article: Oral Chinese herbal medicine in reducing the recurrence of colorectal adenoma after polypectomy: A protocol for the systematic review and meta-analysis
Oral Chinese herbal medicine in reducing the recurrence of colorectal adenoma after polypectomy: A protocol for the systematic review and meta-analysis Open
Background Colorectal adenoma (CRA) is a significant precancerous lesion of sporadic colorectal cancer (CRC). CRA is likely to recur after polypectomy, increasing the risk of CRC. Chinese herbal medicine (CHM) has been used to reduce CRA r…
View article: Orally administered Chinese herbal therapy to assist post-surgical recovery for chronic rhinosinusitis—A systematic review and meta-analysis
Orally administered Chinese herbal therapy to assist post-surgical recovery for chronic rhinosinusitis—A systematic review and meta-analysis Open
This systematic review and meta-analysis aims to: assess the effectiveness and safety of orally administered Chinese herbal medicines (CHMs) as adjuncts to the post-surgical management of chronic rhinosinusitis (CRS); inform clinicians of …
View article: Acupuncture and moxibustion for endometriosis: A systematic review and analysis
Acupuncture and moxibustion for endometriosis: A systematic review and analysis Open
Low to moderate certainty evidence from single studies showed that manual acupuncture may improve pain-related symptoms and quality of life; however, there is insufficient evidence on the overall effectiveness of acupuncture and moxibustio…
View article: Clinical evidence for acupuncture for adult asthma: Systematic review and meta-analysis of randomised sham/placebo-controlled trials
Clinical evidence for acupuncture for adult asthma: Systematic review and meta-analysis of randomised sham/placebo-controlled trials Open
Acupuncture versus sham/placebo control appeared to improve quality of life, FEV1%, symptoms, and asthma control, and reduced exacerbation frequency per year. Further studies with appropriate controls, more participants, and high-quality e…
View article: A Delphi Study of Expert Consensus on Chinese Medicine Syndrome Differentiation and Herbal Use for Early Breast Cancer
A Delphi Study of Expert Consensus on Chinese Medicine Syndrome Differentiation and Herbal Use for Early Breast Cancer Open
Objectives: Chinese herbal medicine (CHM) is widely used in breast cancer, but there is no consensus on the Chinese medicine (CM) syndromes in the different conventional treatment stages (preoperative, postoperative, chemotherapy, radiatio…
View article: Topical Traditional Chinese Medicines for Cancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Topical Traditional Chinese Medicines for Cancer Pain: A Systematic Review and Meta-analysis of Randomized Controlled Trials Open
Background and objectives: Safe and effective management of cancer-related pain is a worldwide challenge. In the search for treatment options, natural products used in Chinese herbal medicines (CHMs) have received attention in clinical stu…
View article: Acupuncture and Moxibustion for Endometriosis: A Systematic Review and Meta-Analysis
Acupuncture and Moxibustion for Endometriosis: A Systematic Review and Meta-Analysis Open
View article: Chinese herbal therapy in the management of rhinosinusitis—A systematic review and meta-analysis
Chinese herbal therapy in the management of rhinosinusitis—A systematic review and meta-analysis Open
This systematic review aims to assess the effects and safety of Chinese herbal medicines (CHMs) in the management of rhinosinusitis (RS); inform clinicians of the current state of the evidence; identify the best available evidence; and sug…
View article: Benefits of herbal formulae containing Poria cocos (Fuling) for type 2 diabetes mellitus: A systematic review and meta-analysis
Benefits of herbal formulae containing Poria cocos (Fuling) for type 2 diabetes mellitus: A systematic review and meta-analysis Open
Background Poria cocos (Schw.) Wolf or Fuling is one of the top 10 most frequently prescribed herbs in China for the treatment of type 2 diabetes mellitus (T2DM). Objective The purpose of this systematic review is to determine the addition…
View article: Chinese herbal medicine for migraine management: A hospital-based retrospective analysis of electronic medical records
Chinese herbal medicine for migraine management: A hospital-based retrospective analysis of electronic medical records Open
Background Migraine is a chronic neurological disease causing significant socioeconomic burden and impaired quality of life. Chinese medicine is commonly used for migraine in China. Clinical trials have generated evidence of the effectiven…
View article: Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature
Natural products for migraine: Data-mining analyses of Chinese Medicine classical literature Open
Background: Treatment effect of current pharmacotherapies for migraine is unsatisfying. Discovering new anti-migraine natural products and nutraceuticals from large collections of Chinese medicine classical literature may assist to address…
View article: Chinese Medicine Syndrome Differentiation for Early Breast Cancer: A Multicenter Prospective Clinical Study
Chinese Medicine Syndrome Differentiation for Early Breast Cancer: A Multicenter Prospective Clinical Study Open
Background Chinese medicine (CM) syndrome differentiation is one of the fundamental principles that guide the practice of Chinese herbal medicine (CHM). CHM has been widely used among breast cancer patients. Contemporary literature varies …
View article: Efficacy and Safety of Oral Chinese Herbal Medicine for Migraine: A Systematic Review and Meta-Analyses Using Robust Variance Estimation Model
Efficacy and Safety of Oral Chinese Herbal Medicine for Migraine: A Systematic Review and Meta-Analyses Using Robust Variance Estimation Model Open
Background Migraine is a prevalent headache disorder with significant impacts on patients' quality of life and economic burden. Chinese herbal medicine (CHM) is commonly prescribed for migraine in China. This review aimed to provide a rigo…