Charlotte A. Chang
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View article: Preexisting yellow fever virus and West Nile virus immunity and pregnancy outcomes in a Nigerian cohort with endemic orthoflavivirus exposure
Preexisting yellow fever virus and West Nile virus immunity and pregnancy outcomes in a Nigerian cohort with endemic orthoflavivirus exposure Open
Yellow fever virus (YFV) and West Nile virus (WNV) co-circulate with other arboviruses, including Zika (ZIKV), dengue (DENV), and chikungunya virus (CHIKV), in sub-Saharan Africa. Associations between preexisting YFV and WNV immunity with …
View article: The effect of dolutegravir on obstetrical outcomes among women living with <scp>HIV</scp>: A retrospective cohort study
The effect of dolutegravir on obstetrical outcomes among women living with <span>HIV</span>: A retrospective cohort study Open
Objective To assess the effect of dolutegravir (DTG) on obstetrical outcomes for women living with HIV (WLWH). Methods This retrospective cohort study evaluated adult WLWH in antenatal care between 2016 and 2022 at two Nigerian centers. Pa…
View article: Preexisting Yellow Fever Virus and West Nile Virus Immunity and Pregnancy Outcomes in a Nigerian Cohort with Endemic Flavivirus Exposure
Preexisting Yellow Fever Virus and West Nile Virus Immunity and Pregnancy Outcomes in a Nigerian Cohort with Endemic Flavivirus Exposure Open
Summary Background Yellow fever virus (YFV) and West Nile virus (WNV) co-circulate with other arboviruses, including Zika (ZIKV), dengue (DENV), and chikungunya virus (CHIKV), in sub-Saharan Africa. Associations between preexisting YFV and…
View article: Patterns of peri-gestational weight change among women living with HIV in Nigeria receiving dolutegravir compared to alternative antiretroviral regimens: a retrospective cohort study
Patterns of peri-gestational weight change among women living with HIV in Nigeria receiving dolutegravir compared to alternative antiretroviral regimens: a retrospective cohort study Open
View article: Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal
Pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 among female sex workers in Dakar, Senegal Open
Background The COVID-19 pandemic had a severe impact globally, yet African populations exhibited unexpectedly lower rates of severe disease and mortality. We investigated the potential role of pre-existing immunity in shaping the epidemiol…
View article: Antiretroviral therapy retention, adherence, and clinical outcomes among postpartum women with HIV in Nigeria
Antiretroviral therapy retention, adherence, and clinical outcomes among postpartum women with HIV in Nigeria Open
While research involving pregnant women with HIV has largely focused on the antepartum and intrapartum periods, few studies in Nigeria have examined the clinical outcomes of these women postpartum. This study aimed to evaluate antiretrovir…
View article: West African pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2
West African pre-pandemic cross-reactive antibody and cellular responses against SARS-CoV-2 Open
The COVID-19 pandemic had a severe impact globally, yet African populations exhibited unexpectedly lower rates of severe disease and mortality. We investigated the potential role of pre-existing immunity in shaping the epidemiology of COVI…
View article: Antiretroviral therapy retention, adherence, and clinical outcomes among postpartum women with HIV in Nigeria
Antiretroviral therapy retention, adherence, and clinical outcomes among postpartum women with HIV in Nigeria Open
While research involving pregnant women with HIV has largely focused on the antepartum and intrapartum periods, few studies in Nigeria have examined the clinical outcomes of these women postpartum. This study aimed to evaluate antiretrovir…
View article: Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria
Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria Open
View article: Arbovirus surveillance in pregnant women in north-central Nigeria, 2019–2022
Arbovirus surveillance in pregnant women in north-central Nigeria, 2019–2022 Open
View article: The HIV-2 proviral landscape is dominated by defective proviruses
The HIV-2 proviral landscape is dominated by defective proviruses Open
Background: Compared with HIV-1 infection, HIV-2 infection is associated with a slower progression to AIDS. Understanding the persistence of HIV-2 infection might inform the mechanisms responsible for differences in the pathogenicity of HI…
View article: Chikungunya virus antepartum transmission and abnormal infant outcomes in Nigeria
Chikungunya virus antepartum transmission and abnormal infant outcomes in Nigeria Open
Chikungunya virus (CHIKV) has become a global public health concern since the reemergence of the Indian Ocean lineage and expansion of the Asian genotype. CHIKV infection causes acute febrile illness, rash, and arthralgia and during pregna…
View article: Arbovirus surveillance in pregnant women in north-central Nigeria, 2019-2022
Arbovirus surveillance in pregnant women in north-central Nigeria, 2019-2022 Open
The adverse impact of Zika (ZIKV), dengue (DENV), and chikungunya (CHIKV) virus infection in pregnancy has been recognized in Latin America and Asia but is not well studied in Africa. In Nigeria, we screened 1006 pregnant women for ZIKV, D…
View article: SARS-CoV-2 live virus culture and sample freeze-thaw stability
SARS-CoV-2 live virus culture and sample freeze-thaw stability Open
The COVID-19 pandemic has presented unique diagnostic challenges including the need to store and test large number of samples for clinical and research studies. While SARS CoV-2 diagnosis relies on RT-qPCR and antigen testing, live virus c…
View article: High SARS-CoV-2 seroprevalence in Lagos, Nigeria with robust antibody and cellular immune responses
High SARS-CoV-2 seroprevalence in Lagos, Nigeria with robust antibody and cellular immune responses Open
View article: High SARS-CoV-2 seroprevalence in Lagos, Nigeria with robust antibody and cellular responses
High SARS-CoV-2 seroprevalence in Lagos, Nigeria with robust antibody and cellular responses Open
Background Early evidence suggested that the impact of the COVID-19 pandemic was less severe in Africa compared to other parts of the world. However, more recent studies indicate higher SARS-CoV-2 infection and COVID-19 mortality rates on …
View article: Timeliness of Point-of-Care Viral Load Results Improves Human Immunodeficiency Virus Monitoring in Nigeria
Timeliness of Point-of-Care Viral Load Results Improves Human Immunodeficiency Virus Monitoring in Nigeria Open
Background Human immunodeficiency virus (HIV) viral load (VL) monitoring is critical for antiretroviral therapy (ART) management. Point-of-care (POC) VL testing has been reported to be feasible and preferred over standard-of-care (SOC) tes…
View article: Clinical Outcomes in a Randomized Controlled Trial Comparing Point-of-Care With Standard Human Immunodeficiency Virus (HIV) Viral Load Monitoring in Nigeria
Clinical Outcomes in a Randomized Controlled Trial Comparing Point-of-Care With Standard Human Immunodeficiency Virus (HIV) Viral Load Monitoring in Nigeria Open
Background Point-of-care (POC) viral load (VL) tests provide results within hours, enabling same-day treatment interventions. We assessed treatment outcomes with POC vs standard-of-care (SOC) VL monitoring. Methods We implemented a randomi…
View article: Sars-Cov-2 antigen tests predict infectivity based on viral culture: comparison of antigen, PCR viral load, and viral culture testing on a large sample cohort
Sars-Cov-2 antigen tests predict infectivity based on viral culture: comparison of antigen, PCR viral load, and viral culture testing on a large sample cohort Open
View article: SARS-CoV-2 Antigen Tests Predict Infectivity Based on Viral Culture: Comparison of Antigen, PCR Viral Load, and Viral Culture Testing on a Large Sample Cohort
SARS-CoV-2 Antigen Tests Predict Infectivity Based on Viral Culture: Comparison of Antigen, PCR Viral Load, and Viral Culture Testing on a Large Sample Cohort Open
The relationship of SARS-CoV-2 antigen testing results, viral load, and viral culture detection remains to be fully defined. Presumptively, viral culture can provide a surrogate measure for infectivity of sampled individuals, and thereby i…
View article: Detection of Inducible Replication-Competent HIV-1 Subtype C Provirus Despite Long-Term Antiretroviral Treatment in Perinatally Infected Adolescents in Botswana
Detection of Inducible Replication-Competent HIV-1 Subtype C Provirus Despite Long-Term Antiretroviral Treatment in Perinatally Infected Adolescents in Botswana Open
Although antiretroviral therapy (ART) effectively suppresses HIV replication, the latent reservoir remains the barrier to HIV eradication. It remains unknown whether long-term ART impacts levels of inducible replication-competent provirus.…
View article: Longitudinal evaluation of adherence, retention, and transition patterns of adolescents living with HIV in Nigeria
Longitudinal evaluation of adherence, retention, and transition patterns of adolescents living with HIV in Nigeria Open
Our evaluation found considerable proportions of adolescents lost to follow-up throughout the ART program cascade. We also found discrepancies between the proportions of patients with ≥95% MPR and the proportions with VL suppression, sugge…
View article: Safety and efficacy of rifabutin among HIV/TB-coinfected children on lopinavir/ritonavir-based ART
Safety and efficacy of rifabutin among HIV/TB-coinfected children on lopinavir/ritonavir-based ART Open
Background TB is the leading cause of death among HIV-infected children, yet treatment options for those who require PI-based ART are suboptimal. Rifabutin is the preferred rifamycin for adults on PI-based ART; only one study has evaluated…
View article: The role of point-of-care viral load monitoring in achieving the target of 90% suppression in HIV-infected patients in Nigeria: study protocol for a randomized controlled trial
The role of point-of-care viral load monitoring in achieving the target of 90% suppression in HIV-infected patients in Nigeria: study protocol for a randomized controlled trial Open
US National Institutes of Health Clinical Trials.gov: NCT03533868 . Date of Registration: 23 May 2018. Protocol Version: 10. Protocol Date: 30 March 2018.
View article: A modified anthrax toxin-based enzyme-linked immunospot assay reveals robust T cell responses in symptomatic and asymptomatic Ebola virus exposed individuals
A modified anthrax toxin-based enzyme-linked immunospot assay reveals robust T cell responses in symptomatic and asymptomatic Ebola virus exposed individuals Open
Our data provide further evidence of EBOV exposure in individuals without EVD-like illness and, for the first time, demonstrate that these individuals have T cell responses that are stronger in magnitude compared to severe cases. These fin…
View article: Sustained Specific and Cross-Reactive T Cell Responses to Zika and Dengue Virus NS3 in West Africa
Sustained Specific and Cross-Reactive T Cell Responses to Zika and Dengue Virus NS3 in West Africa Open
Recent studies on the role of T cells in Zika virus (ZIKV) infection have shown that T cell responses to Asian ZIKV infection are important for protection, and that previous dengue virus (DENV) exposure amplifies the protective T cell resp…
View article: Continued Transmission of Zika Virus in Humans in West Africa, 1992–2016
Continued Transmission of Zika Virus in Humans in West Africa, 1992–2016 Open
First identified in 1947 in Uganda, Zika virus (ZIKV) has remained largely unstudied until the recent outbreak in Latin America. This study aimed to measure the prevalence of ZIKV in febrile patients in Senegal and Nigeria in samples colle…
View article: Long-Term Outcomes on Antiretroviral Therapy in a Large Scale-Up Program in Nigeria
Long-Term Outcomes on Antiretroviral Therapy in a Large Scale-Up Program in Nigeria Open
While improved access to HIV care and treatment remains a challenge in Nigeria, our study shows that a high quality of care was achieved as evidenced by strong long-term clinical, immunologic and virologic outcomes.
View article: Tuberculosis Incidence and Risk Factors Among Human Immunodeficiency Virus (HIV)-Infected Adults Receiving Antiretroviral Therapy in a Large HIV Program in Nigeria
Tuberculosis Incidence and Risk Factors Among Human Immunodeficiency Virus (HIV)-Infected Adults Receiving Antiretroviral Therapy in a Large HIV Program in Nigeria Open
Background. Despite the benefits of antiretroviral therapy (ART), tuberculosis (TB) is the leading cause of mortality among human immunodeficiency virus (HIV)-infected persons in Africa. Nigeria bears the highest TB burden in Africa and se…