Charlotte C. Koster
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View article: Exploration of mRNA-sized RNA import into <i>Saccharomyces cerevisiae</i> mitochondria by a combined synthetic biology and adaptive laboratory evolution approach
Exploration of mRNA-sized RNA import into <i>Saccharomyces cerevisiae</i> mitochondria by a combined synthetic biology and adaptive laboratory evolution approach Open
Efficient gene integration using RNA-guided endonucleases has not yet been achieved in the mitochondrial genome. Import of nucleic acids into mitochondria, a controversial feature, is essential for implementation of Cas9-mediated genome en…
View article: Long‐read direct RNA sequencing of the mitochondrial transcriptome of <i>Saccharomyces cerevisiae</i> reveals condition‐dependent intron abundance
Long‐read direct RNA sequencing of the mitochondrial transcriptome of <i>Saccharomyces cerevisiae</i> reveals condition‐dependent intron abundance Open
Mitochondria fulfil many essential roles and have their own genome, which is expressed as polycistronic transcripts that undergo co‐ or posttranscriptional processing and splicing. Due to the inherent complexity and limited technical acces…
View article: Long-read direct RNA sequencing of the mitochondrial transcriptome of<i>Saccharomyces cerevisiae</i>reveals condition-dependent intron turnover
Long-read direct RNA sequencing of the mitochondrial transcriptome of<i>Saccharomyces cerevisiae</i>reveals condition-dependent intron turnover Open
Mitochondria fulfil many essential roles and have their own genome, which is expressed as polycistronic transcripts that undergo co- or post-transcriptional processing and splicing. Due to inherent complexity and limited technical accessib…
View article: Synthetic Genomics From a Yeast Perspective
Synthetic Genomics From a Yeast Perspective Open
Synthetic Genomics focuses on the construction of rationally designed chromosomes and genomes and offers novel approaches to study biology and to construct synthetic cell factories. Currently, progress in Synthetic Genomics is hindered by …
View article: Correction to: Class‑II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis
Correction to: Class‑II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis Open
Following publication of the original article [1], the authors reported errors in the text of the Results section and in Table 2. It refers to a mutation in a yeast gene as VPS1I410L and to the corresponding change in the Vps1 a…
View article: Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis
Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis Open
View article: Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis
Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis Open
Background In most fungi, quinone-dependent Class-II dihydroorotate dehydrogenases (DHODs) are essential for pyrimidine biosynthesis. Coupling of these Class-II DHODHs to mitochondrial respiration makes their in vivo activity dependent on …
View article: Additional file 2 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis
Additional file 2 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis Open
Additional file 2. Protein IDs Ura9 orthologs.
View article: Additional file 1 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis
Additional file 1 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis Open
Additional file 1. Protein sequences Ura9 orthologs.
View article: Additional file 4 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis
Additional file 4 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis Open
Additional file 4. Codon-optimized protein sequences.
View article: Additional file 3 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis
Additional file 3 of Class-II dihydroorotate dehydrogenases from three phylogenetically distant fungi support anaerobic pyrimidine biosynthesis Open
Additional file 3. Raw phylogenetic tree.
View article: Phenotype-Independent Isolation of Interspecies Saccharomyces Hybrids by Dual-Dye Fluorescent Staining and Fluorescence-Activated Cell Sorting
Phenotype-Independent Isolation of Interspecies Saccharomyces Hybrids by Dual-Dye Fluorescent Staining and Fluorescence-Activated Cell Sorting Open
Interspecies hybrids of Saccharomyces species are found in a variety of industrial environments and often outperform their parental strains in industrial fermentation processes. Interspecies hybridization is therefore increasingly c…
View article: Laboratory Evolution of a Biotin-Requiring Saccharomyces cerevisiae Strain for Full Biotin Prototrophy and Identification of Causal Mutations
Laboratory Evolution of a Biotin-Requiring Saccharomyces cerevisiae Strain for Full Biotin Prototrophy and Identification of Causal Mutations Open
Biotin prototrophy is a rare, incompletely understood, and industrially relevant characteristic of Saccharomyces cerevisiae strains. The genome of the haploid laboratory strain CEN.PK113-7D contains a full complement of biotin biosynthesis…