Doris Maier
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View article: Reassessing the Role of Machine Learning in Clinical Prediction: A Benchmark of Predicting Walking Function after Spinal Cord Injury
Reassessing the Role of Machine Learning in Clinical Prediction: A Benchmark of Predicting Walking Function after Spinal Cord Injury Open
In light of growing biomedical data, machine learning (ML) models offer tremendous potential for personalized prediction in medicine. However, the additional value provided by these computational tools should always be critically evaluated…
View article: Exploring synthetic controls in rare diseases with a proof of concept in spinal cord injury
Exploring synthetic controls in rare diseases with a proof of concept in spinal cord injury Open
Background Successfully completing clinical trials for rare and heterogeneous disorders, like spinal cord injuries (SCI), remains challenging, thereby reducing the ability to test and translate promising preclinical findings. We propose sy…
View article: Enhanced clinical trial stratification in spinal cord injury: the value of electrophysiology
Enhanced clinical trial stratification in spinal cord injury: the value of electrophysiology Open
There are no approved interventional therapies, aside from neurorehabilitation, that enhance neurological recovery after acute traumatic spinal cord injury (SCI). A key challenge is the lack of biomarkers surpassing clinical standards for …
View article: Feasibility and Sensitivity of Wearable Sensors for Daily Activity Monitoring in Spinal Cord Injury Trials
Feasibility and Sensitivity of Wearable Sensors for Daily Activity Monitoring in Spinal Cord Injury Trials Open
Background The aim of clinical trials for spinal cord injury (SCI) is to improve everyday-life activity outcomes, which requires reliable methods for monitoring patient activity. This study evaluates sensor-derived activity metrics in comp…
View article: Age- and sex-specific reference values for CT-based low skeletal muscle quantity and quality in healthy living kidney donors
Age- and sex-specific reference values for CT-based low skeletal muscle quantity and quality in healthy living kidney donors Open
Background Computed tomography (CT) imaging is a useful tool for assessing skeletal muscle mass and quality. The present study aimed to determine age- and sex-specific reference values for CT-based skeletal muscle markers in a healthy popu…
View article: Impact of Preoperative CT-Measured Sarcopenia on Clinical, Pathological, and Oncological Outcomes After Elective Rectal Cancer Surgery
Impact of Preoperative CT-Measured Sarcopenia on Clinical, Pathological, and Oncological Outcomes After Elective Rectal Cancer Surgery Open
Background: Patients with rectal cancer may be exposed to a loss of muscle strength and quality. This study aimed to assess the role of preoperative CT-based sarcopenia on postoperative clinical, pathological, and oncological outcomes afte…
View article: Early Sacral Neuromodulation: A Promising Opportunity or an Overload for Patients with a Recent Spinal Cord Injury? A Cross-Sectional Study
Early Sacral Neuromodulation: A Promising Opportunity or an Overload for Patients with a Recent Spinal Cord Injury? A Cross-Sectional Study Open
Background: A solid rationale exists for early sacral neuromodulation in the form of causal therapy that improves neurogenic lower urinary tract dysfunction after complete spinal cord injury. However, the short and early time frame for min…
View article: Balancing Stability and Recovery: Impact of Spinal Fusion Length on Surgical Site Infections and Functional Outcomes in Traumatic Thoracic and Thoracolumbar Spinal Cord Injuries
Balancing Stability and Recovery: Impact of Spinal Fusion Length on Surgical Site Infections and Functional Outcomes in Traumatic Thoracic and Thoracolumbar Spinal Cord Injuries Open
Background Spinal surgeries after traumatic thoracic or thoracolumbar spinal cord injuries (SCI) often involve extensive instrumentation, leading to an increased risk of surgical site infections (SSIs) and complications. This study investi…
View article: Safety and efficacy of intrathecal antibodies to Nogo-A in patients with acute cervical spinal cord injury: a randomised, double-blind, multicentre, placebo-controlled, phase 2b trial
Safety and efficacy of intrathecal antibodies to Nogo-A in patients with acute cervical spinal cord injury: a randomised, double-blind, multicentre, placebo-controlled, phase 2b trial Open
EU program Horizon2020; Swiss State Secretariat for Education, Research and Innovation; Wings for Life; the Swiss Paraplegic Foundation; and the CeNeReg project of Wyss Zurich (University of Zurich and Eidgenössische Technische Hochschule …
View article: Exploring the potential of routine serological markers in predicting neurological outcomes in spinal cord injury
Exploring the potential of routine serological markers in predicting neurological outcomes in spinal cord injury Open
Spinal cord injury (SCI) is a rare condition with a heterogeneous presentation, making the prediction of recovery challenging. However, serological markers have been shown to be associated with severity and long-term recovery following SCI…
View article: Prediction of segmental motor outcomes in traumatic spinal cord injury: Advances beyond sum scores
Prediction of segmental motor outcomes in traumatic spinal cord injury: Advances beyond sum scores Open
Our approach is the first to provide predictions across all motor segments independent of the level and severity of SCI. We provide a machine learning concept that is highly interpretable, i.e. the prediction formation process is transpare…
View article: Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury
Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human spinal cord injury Open
View article: Extent of Traumatic Spinal Cord Injury Is Lesion Level Dependent and Predictive of Recovery: A Multicenter Neuroimaging Study
Extent of Traumatic Spinal Cord Injury Is Lesion Level Dependent and Predictive of Recovery: A Multicenter Neuroimaging Study Open
Assessing the extent of the intramedullary lesion after spinal cord injury (SCI) might help to improve prognostication. However, because the neurological level of injury impacts the recovery potential of SCI patients, the question arises w…
View article: Prognostic value of tissue bridges in cervical spinal cord injury: a longitudinal, multicentre, retrospective cohort study
Prognostic value of tissue bridges in cervical spinal cord injury: a longitudinal, multicentre, retrospective cohort study Open
Wings for Life, International Foundation for Research in Paraplegia, EU project Horizon 2020 (NISCI grant), and ERA-NET NEURON.
View article: The revised zone of partial preservation (ZPP) in the 2019 International Standards for Neurological Classification of Spinal Cord Injury: ZPP applicability in incomplete injuries
The revised zone of partial preservation (ZPP) in the 2019 International Standards for Neurological Classification of Spinal Cord Injury: ZPP applicability in incomplete injuries Open
View article: Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human traumatic spinal cord injury
Untargeted blood serum proteomics identifies novel proteins related to neurological recovery after human traumatic spinal cord injury Open
View article: An unsupervised machine learning approach to predict recovery from traumatic spinal cord injury
An unsupervised machine learning approach to predict recovery from traumatic spinal cord injury Open
Background Neurological and functional recovery after traumatic spinal cord injury (SCI) is highly heterogeneous, challenging outcome predictions in rehabilitation and clinical trials. We propose k-nearest neighbour (k-NN) matching as a da…
View article: Bewegungsanalyse bei Querschnittverletzungen
Bewegungsanalyse bei Querschnittverletzungen Open
Zusammenfassung Für motorisch inkomplette Querschnittgelähmte ist eine Verbesserung der Gehfunktion ein wichtiges Ziel im Rehabilitationsprogramm. In den spezialisierten Behandlungszentren dienen der 6‑Minuten-Gehtest, der 10-Meter-Gehtest…
View article: Walking Outcome After Traumatic Paraplegic Spinal Cord Injury: The Function of Which Myotomes Makes a Difference?
Walking Outcome After Traumatic Paraplegic Spinal Cord Injury: The Function of Which Myotomes Makes a Difference? Open
Background Accurate prediction of walking function after a traumatic spinal cord injury (SCI) is crucial for an appropriate tailoring and application of therapeutical interventions. Long-term outcome of ambulation is strongly related to re…
View article: Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections Open
View article: Identification of Risk Factors for Dysphagia after Traumatic Cervical Spinal Cord Injury: A Retrospective Study
Identification of Risk Factors for Dysphagia after Traumatic Cervical Spinal Cord Injury: A Retrospective Study Open
View article: International surveillance study in acute spinal cord injury confirms viability of multinational clinical trials
International surveillance study in acute spinal cord injury confirms viability of multinational clinical trials Open
View article: Prediction of bowel management independence after ischemic spinal cord injury
Prediction of bowel management independence after ischemic spinal cord injury Open
The model may be employed in clinical practice to counsel patients, to define the rehabilitation aims and to estimate the need of assistance after discharge, as well as in the research field for the optimization of patients' allocation in …
View article: Inclusive Trial Designs in Acute Spinal Cord Injuries: Prediction–Based Stratification of Clinical Walking Outcome and Projected Enrolment Frequencies
Inclusive Trial Designs in Acute Spinal Cord Injuries: Prediction–Based Stratification of Clinical Walking Outcome and Projected Enrolment Frequencies Open
Background New therapeutic approaches in neurological disorders are progressing into clinical development. Past failures in translational research have underlined the critical importance of selecting appropriate inclusion criteria and prim…
View article: Segmental analysis in cervical spinal cord injury reveals the recovery potential of hand muscles with preserved corticospinal tract: Insights beyond impairment scales
Segmental analysis in cervical spinal cord injury reveals the recovery potential of hand muscles with preserved corticospinal tract: Insights beyond impairment scales Open
Cervical spinal cord injury (SCI) severely impacts widespread bodily functions with extensive impairments for individuals, who prioritize regaining hand function. Although prior work has focused on the recovery at the person- level, the fa…
View article: Das deutschlandweite, webbasierte ParaReg-Register zur lebenslangen Dokumentation von Querschnittgelähmten – Datenmodell, rechtlich-ethische Voraussetzungen und technische Implementierung
Das deutschlandweite, webbasierte ParaReg-Register zur lebenslangen Dokumentation von Querschnittgelähmten – Datenmodell, rechtlich-ethische Voraussetzungen und technische Implementierung Open
Ziel der Studie In Deutschland unterscheiden sich die Behandlungspfade von frisch Querschnittgelähmten in Abhängigkeit von intrinsisch-krankheitsspezifischen und extrinsischen Faktoren erheblich. Welche dieser Faktoren mit einem verbessert…
View article: Natural Progression of Routine Laboratory Markers after Spinal Trauma: A Longitudinal, Multi-Cohort Study
Natural Progression of Routine Laboratory Markers after Spinal Trauma: A Longitudinal, Multi-Cohort Study Open
Our objective was to track and quantify the natural course of serological markers over the 1st year following spinal cord injury. For that purpose, data on serological markers, demographics, and injury characteristics were extracted from m…
View article: Natural Progression of Routine Laboratory Markers following Spinal Trauma: A Longitudinal, Multi-Cohort Study
Natural Progression of Routine Laboratory Markers following Spinal Trauma: A Longitudinal, Multi-Cohort Study Open
Objective To track and quantify the natural course of hematological markers over the first year following spinal cord injury. Methods Data on hematological markers, demographics, and injury characteristics were extracted from medical recor…
View article: Association of timing of gabapentinoid use with motor recovery after spinal cord injury
Association of timing of gabapentinoid use with motor recovery after spinal cord injury Open
This study provides Class IV evidence that gabapentinoids improve motor recovery for individuals with acute spinal cord injury.
View article: Advanced neurological recovery translates into greater long-term functional independence after acute spinal cord injury
Advanced neurological recovery translates into greater long-term functional independence after acute spinal cord injury Open
The absence of effective pharmacological interventions in acute traumatic spinal cord injury is a major problem in its management. A critical barrier in identifying such interventions lies in the vast heterogeneity of recovery profiles, wh…